Incessant Role of Fibroblast in Malignant Transformation of Gnathic Fibro-Osseous Lesions? – Should We Rework on Treatment Strategies
Suganya
Panneer Selvam
Saveetha Dental College and Hospitals, Saveetha Institute of
Medical and Technical Sciences, Saveetha University, Chennai,
India.
author
Pratibha
Ramani
Saveetha Dental College and Hospitals, Saveetha Institute of
Medical and Technical Sciences, Saveetha University, Chennai,
India.
author
Ramya
Ramadoss
Saveetha Dental College and Hospitals, Saveetha Institute of
Medical and Technical Sciences, Saveetha University, Chennai,
India.
author
Lakshmi
Trivandrum Anandapadmanabhan
Saveetha Dental College and Hospitals, Saveetha Institute of
Medical and Technical Sciences, Saveetha University, Chennai,
India.
author
Sandhya
Sundar
Saveetha Dental College and Hospitals, Saveetha Institute of
Medical and Technical Sciences, Saveetha University, Chennai,
India.
author
text
article
2022
eng
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2177
2178
https://journal.waocp.org/article_90217_dee758df2e88bff308f17c6181a1a1e8.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2177
Exposure to Outdoor Tobacco Advertisements Near Home is Associated with Smoking among Youth in Indonesia
Nurhayati
Nurhayati
Faculty of Public Health, Universitas Islam Negeri Sumatera Utara, Medan, Indonesia.
author
Dian
Kusuma
Centre for Health Economics & Policy
Innovation, Imperial College Business School, London, UK.
author
Azhari
Tarigan
Faculty of Public Health, Universitas Islam Negeri Sumatera Utara, Medan, Indonesia.
author
Putra
Siregar
Faculty of Public Health, Universitas Islam Negeri Sumatera Utara, Medan, Indonesia.
author
Reni
Hasibuan
Faculty of Public Health, Universitas Islam Negeri Sumatera Utara, Medan, Indonesia.
author
Abdillah
Ahsan
Faculty of Economics and Business, University of Indonesia, Depok,
Indonesia.
author
text
article
2022
eng
Background: The prevalence of cigarette smoking among adults is persistently high, and among youth is increasing in Indonesia. Objective: This study aims to examine the association between youth smoking behavior and outdoor tobacco adverts near home in Indonesia. Methods: We conducted a cross-sectional survey of 3,557 students in North Sumatera during September-November 2020. The main independent variables include seeing tobacco advertisements near home, near school, on social media. The outcome variables included ever smoked and smoked in the last ten days. Results: We found significant associations between exposure to outdoor tobacco adverts near home and youth smoking. High school students who reported seeing tobacco adverts near home were 1.42 times more likely to smoke and 2.29 times more likely to smoke in the last ten days. Moreover, students at private schools (a proxy for higher income) exposed to tobacco adverts near home were 1.56 times more likely to smoke and 2.93 times more likely to smoke in the last ten days. Conclusion: Exposure to outdoor tobacco advertisements near home is associated with smoking among youth in Indonesia. Comprehensive tobacco control efforts are needed, including through a ban of outdoor tobacco adverts.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2179
2183
https://journal.waocp.org/article_90182_b60b187f2dae6dfd129f6d014767a5cb.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2179
Comparison of High-Resolution Melting (HRM) Analysis with Direct Sequencing for the Detection of DNMT3A Mutations in AML Patients
Mohammadreza
Moonesi
Department of Hematology, Faculty of Paramedicine, AJA University of Medical Sciences, Tehran, Iran.
author
Saeed
Zaka Khosravi
Department of Hematology, Faculty of Paramedicine, AJA University of Medical Sciences, Tehran, Iran.
author
Alireza
Moradabadi
Department of Medical
Laboratory, Khomein University of Medical Sciences, Khomein, Iran.
author
Mohsen
Rajaeinejad
Department of Oncology and Hematology, Faculty of
Medicine, AJA University of Medical Sciences, Tehran, Iran.
author
Mohammad Foad
Heidari
DNA Molecular Identification Center, Aja University of Medical
Sciences, Tehran, Iran.
author
Golnoosh
Mahjub
Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences,
Tehran, Iran.
author
Ali
Noroozi-Aghideh
Department of Hematology, Faculty of Paramedicine, AJA University of Medical Sciences, Tehran, Iran.
author
text
article
2022
eng
Objective: Acute myeloid leukemia (AML) is caused by abnormal gene expression following mutations. Many of the mutations in AML lead to gene instability and poor response to treatment. Among these mutations, DNMT3A mutation is exceedingly important due to its major role in methylation and its effect on the expression of other genes. Aberrant methylation due to DNMT3A mutations that mostly occur in exon 23, affects the overall survival (OS) of patients with AML and myelodysplastic syndromes (MDS) showing the importance of identification of these mutations. According to the association of these mutations with short overall survival and disease progression in AML patients, we aimed to investigate DNMT3A gene exon 23 mutations using HRM. Methods: Fifty peripheral blood samples were taken from patients with AML. Mononuclear cells were isolated by ficoll method, and DNA was extracted. Then, mutation detection was detected using the HRM method. Efficacy of the HRM method in mutation detection was compared with direct sequencing method as gold standard. Results: Mutations in codon 23 of the DNMT3A gene were detected in 5 patients (10%). All of the detected mutations were missense type. A comparison between direct sequencing and HRM analysis demonstrated full concordance of mutation detection. Conclusion: According to the full consistency between the HRM and direct sequencing methods, HRM is suggested to be adopted as an alternative for the common time-consuming methods in detecting the gene mutations.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2185
2189
https://journal.waocp.org/article_90213_0b9f040a4601276e42b14835bdee3a72.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2185
SARS-CoV2 Infection and Comorbidities, Role in Oncogenesis
Liudmila
Spirina
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 5 Koopertivny street,
Tomsk, 634050, Russia.
author
Nadezhda
Masunova
Siberian State Medical University, 2, Moskovsky trakt, Tomsk, 634050, Russia.
author
Vladimir
Masunov
Siberian State Medical University, 2, Moskovsky trakt, Tomsk, 634050, Russia.
author
Victoria
Makova
Second Medical Unit,
Department of Health, Tomsk Region, 3, Bela Kun Street, Tomsk, 634050, Russia.
author
Yumzhana
Dagbaeva
Second Medical Unit,
Department of Health, Tomsk Region, 3, Bela Kun Street, Tomsk, 634050, Russia.
author
Irina
Kovaleva
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 5 Koopertivny street,
Tomsk, 634050, Russia.
author
text
article
2022
eng
The widespread infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) significantly impacts major human diseases. It is undoubtedly evident that cancer patients are more susceptible to the infection and at a higher risk of severe COVID-19 than the general population. Moreover, the rise in cancers incidence is waiting in the Globe as a long-term effect of post-COVID-19 complications. Multiple mostly unknown mechanisms participate and determine the oncogenic impact of virus-induced transformation. Imbalance in oncogenesis is considered critical in cancer development. Modified immunogenicity and metabolic features emerge as pivotal in COVID-19 pathogenesis and the organism system’s response. The molecular mechanisms of the onset of the metabolic disorder have not yet been fully elucidated. The pathology is complicated, multifactorial, and emerging in various processes. Preventive anticancer therapy taking into account the change in metabolic processes, helps them respond better to anti-COVID-19 treatment than relying only on antiviral drugs. The modified therapeutic algorithm was provided to reduce the likelihood of post-acute complications in patients with preexisting pathologies and the onset of other chronic pathologies and cancers.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2191
2197
https://journal.waocp.org/article_90192_89339aa56ddc346f9bce63309e6b4690.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2191
What is the Potential Interplay between Microbiome and Tumor Microenvironment in Oral Squamous Cell Carcinomas?
Chen-Xi
Li
Surgical Department of Oral and Maxillofacial Oncology, the First Affiliated Hospital of Xinjiang Medical University. Urumqi
830054, China.
author
Hui
Liu
Department of Oral and Maxillofacial Surgery, Shanghai
Stomatological Hospital & School of Stomatology, Fudan University. Shanghai 200003, China.
author
Zhong-Cheng
Gong
Surgical Department of Oral and Maxillofacial Oncology, the First Affiliated Hospital of Xinjiang Medical University. Urumqi
830054, China.
author
text
article
2022
eng
Oral cancer, with an around 50% mortality rate, is one of the most common malignancies world-wide. It is often detected in advanced or terminal stage and has a poor prognosis, although substantial progress in cancer management. Microbiome has become an increasingly recognized factor that may contribute to the cancerous development. Oral microbiological population comprising more than 700 bacterial species, varies since saliva and different habitats of oral cavity. A shift of composition of oral microbiome from usual condition to functional inflammation to pathological state has been discovered amongst patients with premalignant disorders and oral carcinoma, with evidence suggesting the tumor microenvironment (TME) could strongly exacerbate the influence of oral microorganisms. The complex interactions taking place in either cancer formation or progression have been evaluated in several publications, however given their results’ heterogeneity, a review is needed to correctly untangle the potential correlation in this group of pro-carcinogenesis. In this review, we briefly summarize our current knowledge of the role of oral microbiome, focusing on its potential crosstalk with TME in oral squamous cell carcinomas (OSCC) more precisely, and pave the way for manipulating oral microbiome to deal with OSCC in the future.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2199
2213
https://journal.waocp.org/article_90200_9112455be274922a0a4de5be38b44101.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2199
A Prospective Pooled Analysis of Meat Mutagens and Colorectal Adenoma and Cancer in the US and EPIC Studies: Findings with an Emphasis on Improving Exposure Measurements
Long
Nguyen
Department of Internal Medicine, Bach Mai University hospital, Hanoi city, Viet Nam.
author
Binh
Nguyen
Food Safety Management Authority of Bac
Ninh, Bac Ninh City, Vietnam.
author
Ngoan
Le
Institute of Research and Development, Duy Tan University, Da Nang, Vietnam.
author
text
article
2022
eng
Background: In animal studies, heterocyclic amines (HCAs) are recognized as having strong carcinogenicity, therefore we have hypothesized that HCAs might be associated with the risk of colorectal adenoma (CRA) and cancer (CRC). Methods: We used the Keywords of “Heterocyclic amines and colorectal cancer” to search, there were showing published articles (n=200). After reviews of titles, abstracts, and full articles, seven prospective cohort studies were included in the pooled analysis. Exposures to HCAs 2-amino-3,8-dimethylimidazo(4,5-j)quinoxaline (MeIQx), 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), 2-amino-3,4,8-trimethylimidazo(4,5-f)quinoxaline (DiMeIQx), meat-derived mutagenicity (MDM), and the risk of CRA and CRC were examined. The estimated HCA intake as ng/day and ng/1,000 kcal/day by participants and by studies were examined. The ln(HR) and se(ln(HR)) were estimated from the multivariable-adjusted HR, 95%CI derived from seven published prospective studies in the US and EPIC. The random pooled multivariable-adjusted HR, 95%CI was analyzed using ln(HR) and se(ln(HR)) by STATA-10. Results: For CRC and HCA intake, the null association was observed for MDM, the random pooled multivariable-adjusted HR, (95%CI): 1.11, (1.00, 1.23); for PhIP: 1.00, (0.91, 1.09); and for DiMeIQx: 1.03, (0.87, 1.22). A significant positive association was seen for MeIQx, the random pooled multivariable-adjusted HR, (95%CI):1.12, (1.03, 1.22). For CRA and HCA intake, the null association was observed for MDM, randomly pooled multivariable-adjusted HR, (95%CI): 1.15, (0.99, 1.34), and for DiMeIQx: 1.09, (0.97, 1.23). A significant positive association was seen for PhIP, the random pooled multivariable-adjusted HR, (95%CI): 1.19, (1.02, 1.39), and for MeIQx: 1.17, (1.01, 1.35). The major instances of HCAs were contributed by chicken (54%-74%) for PhIP and by red meat (83%-92%) for MeIQx. However, the estimated PhIP intake (ng/1,000 kcal/day) was remarkably different between studies. Conclusions: We observed a positive association between exposures to MeIQx and the risk of both CRC and CRA which supports the hypothesis of the role of HCAs in developing CRA and CRC. Improving the quality of the estimated HCA intake would be highly concerned for further investigation.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2215
2224
https://journal.waocp.org/article_90208_6e46b7315c26453cfb3ecc737d18f5dc.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2215
Combined Blockade Of PD-1 and TIGIT is not Sufficient to Improve the Function Of CD8+ T-Cells in Chronic Lymphocytic Leukemia
Fatemeh
Hatefi
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
author
Hossein
Asgarian-Omran
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
author
Hadi
Hossein-Nataj
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
author
Armin
Akbar
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
author
Ramin
Shekarriz
Gastrointestinal
Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
author
Ehsan
Zaboli
Gastrointestinal
Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
author
Ghasem
Janbabai
Gastrointestinal
Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
author
Mohsen
Tehrani
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
author
text
article
2022
eng
Background and Objective: Blockade of immune checkpoint receptors in the treatment of cancers has been mentioned in several studies. Here, we investigated the efficacy of combined blockade of two inhibitory receptors, PD-1 and TIGIT, in restoring functional features of CD8+ T-cells in CLL. Methods: CD8+ T-cells were separated from the peripheral blood of 11 CLL patients and targeted with malignant B-cells isolated from the same patients. Cells were then stimulated with anti-CD3/CD28 and PMA/ionomycin to assess their proliferative response and cytotoxic activity using MTT and CD107a degranulation assays, respectively. Cytokine production of isolated CD8+ T-cells was also determined using ELISA. Results: There were no significant differences in proliferation and cytotoxic activity of CD8+ T-cells co-blocked with anti-PD-1/TIGIT compared to those single blocked with anti-PD-1, anti-TIGIT, or the control antibody. There was no significant difference in cytokine production of mentioned groups, either. Conclusions: Collectively, combined blockade of PD-1 and TIGIT failed to restore the proliferation and function of CD8+ T-cells isolated from CLL patients.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2225
2231
https://journal.waocp.org/article_90178_fb1bfc910688508f903dd871ec1f0d8b.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2225
Investigating VEGF. miR-145-3p, and miR-101-3p Expression in Patients with Cholangiocarcinoma
Maria Clara
Calastri
Department of Biochemistry and Molecular Biology, Faculty of Medicine of São José do Rio Preto, FAMERP, São José do Rio
Preto-SP, Brazil.
author
Rafael
Ferreira
Department of Gastroenterology, State University of Campinas UNICAMP, Campinas-SP, Brazil.
author
Graciele
Tenani
Department of Biochemistry and Molecular Biology, Faculty of Medicine of São José do Rio Preto, FAMERP, São José do Rio
Preto-SP, Brazil.
author
Lucas
Spinola
Department of Biochemistry and Molecular Biology, Faculty of Medicine of São José do Rio Preto, FAMERP, São José do Rio
Preto-SP, Brazil.
author
Gabriel
Vieira
Department of Biochemistry and Molecular Biology, Faculty of Medicine of São José do Rio Preto, FAMERP, São José do Rio
Preto-SP, Brazil.
author
Maria
Rabaça Roque Botelho
Medical School
of the University of Coimbra, Coimbra, Portugal.
author
Ana Margarida
Abrantes
Biophysics Unit, Faculty of Medicine, University of Coimbra, Polo III - Polo
das Ciencias da Saude, Azinhaga de Santa Comba, Celas, 3000-548 Coimbra, Portugal.
author
José Guilherme
Tralhão
Medical School
of the University of Coimbra, Coimbra, Portugal.
author
Ana Filipa
de Brito
Department of Medical Engineering,
Coimbra, Portugal.
author
Renato Ferreira
da Silva
Department of Biochemistry and Molecular Biology, Faculty of Medicine of São José do Rio Preto, FAMERP, São José do Rio
Preto-SP, Brazil.
author
Rita de Cassia
da Silva
Department of Biochemistry and Molecular Biology, Faculty of Medicine of São José do Rio Preto, FAMERP, São José do Rio
Preto-SP, Brazil.
author
Eliane
Zanovelo
Department of Pathology, Hospital de Base, Medical School of São José do Rio Preto - HB / FAMERP, Brazil.
author
Larissa Bastos
da Costa
Department of Pathological Anatomy, Hospital de Clínicas, Universidade Estadual de Campinas - UNICAMP, Brazil.
author
Daniele
Brito de Souza
Department of Pathology, Hospital de Base, Medical School of São José do Rio Preto - HB / FAMERP, Brazil.
author
Dalisio
Neto
Department of Biochemistry and Molecular Biology, Faculty of Medicine of São José do Rio Preto, FAMERP, São José do Rio
Preto-SP, Brazil.
author
Ilka de Fatima
Ferreira Boin
Faculty of
Medical Sciences of the State University of Campinas, Campinas, Brazil.
author
Doroteia Rossi
Souza
Department of Biochemistry and Molecular Biology, Faculty of Medicine of São José do Rio Preto, FAMERP, São José do Rio
Preto-SP, Brazil.
author
text
article
2022
eng
Introduction: Cholangiocarcinoma (CCA) is the second most common type of primary liver cancer. Several factors, such as epigenetic changes in promoter genes, gene expression, and microRNAs (miR), can contribute to genomic instability in cancer. This study aimed at evaluating the expression of VEGF, miRs 145-3p, and 101-3p in patients with CCA and their potential as biomarkers for diagnosis and prognosis of CCA. Material and methods : Sixty two patients were studied. Out of these 62 patients, 41 cases had confirm CCA and 21 cases had hepatopathies complications. The RNA was extracted from a paraffined tissue block, and then the synthesis of cDNA was performed. The analysis of the expression of VEGF, miR-145-3p, and miR-101-3p was carried out by polymerase chain reaction in real time. Results: The findings revealed that miRs 145-3p and 101-3p were under expressed in the case group compared to the control group (0.46; 0.17; P = 0.0001, respectively). VEGF was overexpressed in the case group compared to the control group (11.8; P = 0.0001). An increase in miR-145-3p expression level was observed in patients with perihilar CCA compared to those with distal CCA (0.51 ± 0.41; 0.17 ± 0.13; P = 0.0698). Survival rate analysis showed that 41.9% of patients with intrahepatic CCA and 31.5% of patients with extrahepatic CCA were free from death within 11 months, leading to a significant difference (P> 0.05). Conclusion: The underexpression of miRNAs, tumor suppressors, the overexpression of VEGF, smoking, and aging were associated with CCA based on our findings. It seems that the reduced expression of the studies miRNAs and increased expression of VEGF can contribute to a decrease in survival rate of patients with tumor in their intrahepatic bile ducts.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2233
2241
https://journal.waocp.org/article_90179_c7cbc4197a71af2b4b30afea506e96ac.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2233
Dissection of Capsid Protein HPV 52 to Rationalize Vaccine Designs Using Computational Approaches Immunoinformatics and Molecular Docking
Moh Egy
Firdaus
Research Center for Genetic Engineering, National Research and Innovation Agency (BRIN), Bogor, 16911, West Java, Indonesia.
author
Apon
Mustopa
Research Center for Genetic Engineering, National Research and Innovation Agency (BRIN), Bogor, 16911, West Java, Indonesia.
author
Lita
Triratna
Research Center for Applied Zoology, National Research and Innovation Agency (BRIN), Bogor, 16911, West Java, Indonesia.
author
Gita
Syahputra
Research Center for Vaccine and Drug, National Research and Innovation Agency (BRIN), Bogor, 16911, West Java, Indonesia.
author
Maritsa
Nurfatwa
Research Center for Genetic Engineering, National Research and Innovation Agency (BRIN), Bogor, 16911, West Java, Indonesia.
author
text
article
2022
eng
Background: Human Papillomavirus type 52 (HPV 52) is considered one of the threatening HPV types inducing cervical cancer worldwide. This study was conducted to address strategies of an effective vaccine against cervical cancer using computational approaches immuno-informatics and molecular docking. Methods: Major capsid protein L1 and L2 HPV 52 (L1 and L2 HPV 52) sequences were investigated by multiple analyses including B and T cell epitope, toxicity, allergenicity, Immunogenicity, epitope conservancy, population coverage, and molecular docking. Results: L1 and L2 HPV 52 showed a conserved sequence among amino acid levels. Q307K, S383D/N, and D473E are found as major mutations in L1, while mutations in L2 are S122T, Q247H, L247S, and E365D. Multiple epitopes were identified and elicited strong immune responses against cross types of HPV in various HLA populations. To enhance vaccine effectiveness that allows having cross-protection over HPV types, N terminus HPV L2 was analyzed suggesting multi-candidates chimeric L1/L2 vaccine design. Conclusion: This study shed a light on a useful pipeline with robust analysis for effective vaccine production.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2243
2253
https://journal.waocp.org/article_90181_d80a37d9c4a730dd900c0b025344f582.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2243
Identification of Differentially Expressed Mirna by Next Generation Sequencing in Locally Advanced Breast Cancer Patients of South Indian Origin
Shyam
Tripathi
Department of Pharmacology, Additional Professor & Head, Jawaharlal Institute of Postgraduate Medical Education and Research
(JIPMER) Puducherry, India.
author
Jayanthi
Mathaiyan
Department of Pharmacology, Additional Professor & Head, Jawaharlal Institute of Postgraduate Medical Education and Research
(JIPMER) Puducherry, India.
author
Smita
Kayal
Department of Pharmacology, Additional Professor & Head, Jawaharlal Institute of Postgraduate Medical Education and Research
(JIPMER) Puducherry, India.
author
Rajesh
Nachiappa Ganesh
Department of Pharmacology, Additional Professor & Head, Jawaharlal Institute of Postgraduate Medical Education and Research
(JIPMER) Puducherry, India.
author
text
article
2022
eng
Purpose: miRNAs are known to be aberrantly expressed in the serum, tissue, and Peripheral Blood Mononuclear Cells (PBMC) of cancer patients and could serve as potential noninvasive diagnostic markers for breast cancer. The aim of this study was to identify the differentially expressed miRNA using next-generation sequencing (NGS) from the paired PBMC samples from breast cancer patients and age-matched healthy individuals and explore their functional significance. Methods: In this study, PBMCs were employed for the detection of miRNAs by NGS in locally advanced breast cancer (LABC) women of South Indian origin who were divided into three age groups, (a) 40yrs-50yrs (b) 50yrs-60yrs and (c) 60yrs-70yrs, compared with age-matched control groups. Results: Four miRNAs (hsa-miR-192-5p, hsa-miR-24-2-2p, hsa-miR-3609, and hsa-miR-664b-3p) were found to be differentially expressed among LABC patients compared with age matched healthy women of the South Indian population. While miR-24-2-5p, miR3609, and miR-664b-3p were down-regulated, miR-192-5p was up-regulated. Gene Ontology (GO) annotations implicated miRNA with signaling pathways in peripheral nerve synapses, glutamatergic synapse, and cell morphogenesis, all of which play a pivotal role in the manifestation of cancer. Conclusion: Four miRNAs- 3 (While miR-24-2-5p, miR3609, and miR-664b-3p) downregulated and one upregulated (miR-192-5p) were identified as potential biomarkers for patients with locally advanced breast cancer. These markers could be validated in studies with a larger sample size.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2255
2261
https://journal.waocp.org/article_90180_3449ccafeac59e792f94b66bb2381ff0.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2255
Salvage Treatment and Outcomes of Locally Advanced Cervical Cancer after Failed Concurrent Chemoradiation with or without Adjuvant Chemotherapy: Post Hoc Data Analysis from the ACTLACC Trial
Tussawan
Asakij
Radiation Oncology Section, Lampang Cancer Hospital, Thailand.
author
Jakkapan
Khunnarong
Department of Obstetrics and Gynecology, Faculty of
Medicine Vajira Hospital, Navamindradhiraj University, Thailand.
author
Siriwan
Tangjitgamol
Women’s Health Center, MedPark Hospital, Bangkok,
Thailand.
author
Kanisa
Rongsriyam
Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Vajira Hospital, Navamindradhiraj
University, Thailand.
author
Ekkasit
Tharavichitkul
Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Chiang Mai University,
Thailand.
author
Chokaew
Tovanabutra
Radiation Oncology Section, Chonburi Cancer Hospital, Thailand.
author
Kannika
Paengchit
Gynecologic Oncology section, Lampang Cancer
Hospital, Thailand.
author
Jirasak
Sukhaboon
Radiation Oncology Section, Lopburi Cancer Hospital, Thailand.
author
Lieutenant Col. Apiradee
Kridakara
Radiation Oncology Section, Bhumibol
Adulyadej Hospital, Thailand.
author
Thiti
Atjimakul
Department of Obstetrics and Gynecology, Prince of Songkla University, Thailand.
author
Piyawan
Pariyawateekul
Obstetrics and
Gynecology Section, Bhumibol Adulyadej Hospital, Thailand.
author
Prapai
Tanprasert
Obstetrics and Gynecology Section, Rajburi Hospital, Thailand.
author
text
article
2022
eng
Objectives: To evaluate the type of salvage treatment and outcomes of patients with locally advanced cervical cancer who failed treatment with concurrent chemoradiation with or without adjuvant chemotherapy. Methods: This was post hoc analyses of data from the randomized trial which included 259 patients who had FIGO stage IIB-IVA and had either pelvic radiation therapy concurrent with cisplatin followed by observation or paclitaxel plus carboplatin. Data of the patients who failed primary treatment were collected: type of salvage treatments, time to progress after salvage therapy, progression-free (PFS) and overall survivals (OS). Results: After primary treatment, 85 patients had either persistence (36.5%), progression (18.8%), or recurrences (44.7%). The sites of failure were loco/regional in 52.9%, systemic failure in 30.6%, and loco-regional and systemic in 16.5%. Chemotherapy was given in 51.8%, being the sole therapy in 34.1%. Majority were combination agents (31.8%), with paclitaxel/carboplatin as the most common regimen. Radiation to the metastatic sites along with chemotherapy was used in 14.1% whereas palliative radiation therapy or supportive care was used in approximately 10% of each. The median time from the start of salvage treatment to progression was 9.2 months (range 0.2-64.0 months) with median PFS of 11.2 months (95% CI, 7.2-15.3 months). Median overall survival 27.3 months (95% CI, 4.4-69.6 months). Conclusions: Chemotherapy, either alone or with radiation therapy, was the most common salvage treatment in LACC after failure from primary treatment. The time to progress and PFS were less than 1 year with OS of approximately 2 years.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2263
2269
https://journal.waocp.org/article_90211_9f235929c77ea2917e7603cfff6b30f0.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2263
Perception and Practice of Cervical Cancer Screening Services and the Role of Social Workers in Facilitating Screening Uptake in Enugu State, Nigeria
Christopher
Ngwu
Department of Social Work, University of Nigeria, Nsukka, Nigeria.
author
Anthony
Iwuagwu
Department of Social Work, University of Nigeria, Nsukka, Nigeria.
author
Samuel
Ebimgbo
Department of Social Work, University of Nigeria, Nsukka, Nigeria.
author
Emeka
Igboeli
Department of Geography, University of Nigeria, Nsukka,
Nigeria.
author
Brian
Eyang
Department of Social Work, University of Calabar, Calabar, Nigeria.
author
Legbel
Ogar
Department of Social Work, University of Calabar, Calabar, Nigeria.
author
text
article
2022
eng
Objective: We examined the perception and practice of cervical cancer screening among women in Enugu State, Nigeria. Methods: We employed mixed methods and conveniently sampled women aged >15 years. The quantitative data were subjected to chi-square and regression analysis while the qualitative data were analyzed using thematic analysis. Results: The study findings show that over 57% of the respondents have a positive perception of cervical cancer screening while over 80% revealed that they practice cervical cancer screening. Factors such as education, income, and residence are significant in predicting the practice of cervical cancer screening. Conclusion: Therefore, social work strategies to leverage these modifiable predictors in facilitating cervical screening uptake are recommended.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2271
2277
https://journal.waocp.org/article_90212_418128eb4ae4d1be26a199d2a5793ac9.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2271
Adjuvant Treatment Approaches after Radical Prostatectomy with Lymph Node Involvement
Hasan
Tavukçu
Department of Urology, University of Health Sciences, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey.
author
Oğuzcan
Erbatu
Department of Urology, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Turkey.
author
Bülent
Akdoğan
Department of Urology, Hacettepe University School of Medicine, Ankara, Turkey.
author
Volkan
İzol
Department of Urology, Cukurova University School of Medicine, Adana, Turkey.
author
Uğur
Yücetaş
Department of Urology, Istanbul Education and Research Hospital, Ministry of Health, Istanbul, Turkey.
author
Sinan
Sözen
Department of Urology, Faculty of Medicine, Gazi University, Ankara, Turkey.
author
Güven
Aslan
Department of Urology, Dokuz Eylul University School of Medicine, Izmir, Turkey.
author
Bahadır
Şahin
Department of Urology, Marmara University School of Medicine, Istanbul, Turkey.
author
İlker
Tinay
Department of Urology, Anadolu Medical Center, Istanbul, Turkey.
author
Talha
Müezzinoğlu
Department of Urology, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Turkey.
author
Sumer
Baltacı
Department of Urology, Ankara University School of Medicine, Ankara, Turkey.
author
text
article
2022
eng
Objective: The aim of this study was to evaluate the adjuvant treatment preferences and effects on disease progression in patients with pathologically positive lymph node prostate cancer. Methods: Patients who underwent radical prostatectomy from the prostate cancer database of the Turkish Urooncology Association with lymph node involvement were included in the study. Database includes prostate cancer patients from many experience Urooncology centers of Turkey. Adjuvant treatment approaches and the factors that effect the PSA recurrrence was analysed. Results: Postoperative median 2 (1-3) lymph nodes were found to be positive, and the median lymph node density was reported as 0.13 (0.07-0.25). Seventy-four percent of patients received adjuvant treatment postoperatively. Seventy four of the patients (46.54%) received hormonal therapy in combination with radiotherapy; 47 of them (29.55%) received only hormonal treatment and 20(12.57%) only received radiotherapy. The number of lymph nodes removed was less in the group requiring adjuvant treatment, and this group had a higher rate of surgical margin positivity and seminal vesicle invasion. In addition, adjuvant treatment group had a statistically significant higher lymph node density. There was no significant difference in Kaplan-Meier method comparing 5-year PSA recurrence-free survival in patients with and without adjuvant therapy. When the patient clustered as non-adjuvant, only hormonal therapy and hormonal therapy with radiotherapy, a significant survival advantage was found in the hormonal therapy with radiotherapy group compared to the other two groups (p=0.043). Conclusion: No significant difference was found between two groups in terms of time until PSA recurrence during our follow-up. In subgroup analysis survival advantage was found in the hormonal therapy with radiotherapy group compared to non-adjuvant and only hormonal therapy groups.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2279
2284
https://journal.waocp.org/article_90183_73d8c90a79bfe88485c521a923645264.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2279
PD-L1 and the Clinical Outcomes of Ovarian Cancer: Meta-Analysis and Bioinformatical Analysis
Xiaoling
Shi
Department of Toxicology, Guilin Medical University, Guilin 541004, China.
author
Liu
Yun
Department of Gynaecology and Obstetrics, Kailuan
General Hospital,Tangshan, Hebei, 063000, China.
author
Liu
Chaoqun Liu
Department of Nutrition, School of Medicine, Jinan University, Guangzhou,
Guangdong, China.
author
Hui
Ding
Department of Pharmaceutical Analysis, School of Pharmacy Yancheng Teachers University, Yancheng,
Jiangsu, China.
author
Dan
Liang
Department of Toxicology, Guilin Medical University, Guilin 541004, China.
author
Fang
Geng
Department of Clinical Laboratory, Tangshan Maternity and Children & Health Care Hospital, Tangshan, Hebei,
063000, China.
author
Hainan
Yu
Department of Toxicology, Guilin Medical University, Guilin 541004, China.
author
Jinxiu
Ban
Department of Toxicology, Guilin Medical University, Guilin 541004, China.
author
Jiajing
Li
Department of Toxicology, Guilin Medical University, Guilin 541004, China.
author
Tao
Jiang
Department of Toxicology, Guilin Medical University, Guilin 541004, China.
author
Yi
Sun
Department of Toxicology, Guilin Medical University, Guilin 541004, China.
author
text
article
2022
eng
Objective: A meta-analysis was performed to analyze the association between PD-L1 expression and overall survival (OS) in various tumors and to identify potential targets through biological information analysis. Methods: the data were collected from PubMed and Cochrane library, the all analysis of our study were conducted by STATA software and online website. Results: Ten articles (including 11 studies) that met all inclusion criteria were obtained. The combined HR showed that high PD-L1 expression was significantly associated with poor overall survival (HR = 1.84, 95% CI: 1.15-2.93). Pathway analysis revealed that the upregulated genes were primarily involed in biological processes, including nucleic acid transcription, biosynthesis and negative regulation of cell metabolism. The downregulated genes were primarily involed in the regulation of cell cycle, including chromosome separation and DNA metabolism. The top ten genes that were identified were hub genes (CDK1, CCNB1, CCNA2, KIF11, CDC20, UBE2C, NCAPG, AURKA, AURKB, CHEK1), which had significant function in cell differentiation and virus infection. The Kaplan-Meier survival curve indicated that CCNB1, KIF11, UBE2C, NCAPG, AURKA and CHEK1 were statistically significant (P<0.05). Conclusion: PD-L1 was found to be a latent biomarker for predicting the prognostic value of cancer and also a therapeutic target.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2285
2290
https://journal.waocp.org/article_90214_e59f0ebc082000187d8f51dcab894a1a.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2285
Quality of Life and Psychological Wellbeing of Breast Cancer Survivors in the Kingdom of Saudi Arabia
Munir
Abu-Helalah
Department of Public Health, Faculty of Medicine, Mutah University, Karak, Jordan.tah University, Karak, Jordan.
author
Hani
Mustafa
Department of Internal Medicine, King
Abdulaziz Medical City, AlAhsa, Kingdom of Saudi Arabia.
author
Hussam
Alshraideh
Department of Industrial Engineering, Jordan University of Science
and Technology, Irbid, Jordan.
author
Abdullah
Alsuhail
Comprehensive Cancer Center, King Fahad Medical City (KFMC), Riyadh, Kingdom of Saudi
Arabia.
author
Omar
A.Almousily
King Fahad Medical City (KFMC), Riyadh, Kingdom of Saudi Arabia.
author
Ruba
Al-Abdallah
MENA Center for Research and Development and
Internship, Jordan.
author
Abdulrahman
Al Shehri
Department of Oncology, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.
author
Abdullah Ayed
Al Qarni
Oncology Center, King Abdulaziz Medical City, Riyadh, MNGHA, KSA.
author
Waleed
Al Bukhari
Oncology Center, King Abdulaziz Medical City, Jeddah, MNGHA, KSA.
author
text
article
2022
eng
Introduction: Breast cancer is the most common cancer among Saudi population. Breast cancer patients suffer from several negative consequences after treatment and these include pain, fatigue, sexual problems, appearance and body image concerns, with psychological dysfunction. This could affect the patient quality of life and psychological well-being. Methods: a multicenter cross-sectional study to assess quality of life and psychological wellbeing and their predictors for female breast cancers survivors diagnosed between 1 January 2015 and May 2017 with the assessment conducted at 12 to 36 months after initial diagnosis. Assessment was performed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30), the Breast Module (QLQ-BR23) and the Hospital Anxiety and Depression Scale (HADS). Results: 246 Breast cancer patients participated in the study with a mean age of 49.5±10.9. The mean global health status has a mean of 72.7±23.5. The worst domain of the functioning scales was physical functioning (mean score of 62.14±26.03, while the best scores were for social functioning of 80.06±29.18. For the symptom scales, the worst scores were reported for fatigue and pain. Results of HADS scale showed that 57% had moderate to severe depression, while 44% had moderate to severe anxiety. Only 6.8% of the participants reported receiving psychosocial support. Discussion: Breast cancer survivors in the KSA have overall good quality of life scores when compared with patients from Western countries. However, their psychological wellbeing is more impaired. There is an urgent need for psychosocial support programs and psychological screening and consultation for breast cancer patients at cancer care centers in the KSA.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2291
2297
https://journal.waocp.org/article_90184_087214dfcb18dcc29fee3f8c7e0865b1.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2291
Assessing the Quality of Life in Breast Cancer Women: A Cross Sectional Descriptive Study
Abeer
Rashid
Department of Clinical Pharmacy, College of Pharmacy, Mustansiriyah University, Iraq.
author
Rawaa
Mohammed Hussein
Oncology Teaching Hospital, Medical
City, Iraq.
author
Noor
Hashim
Department of Clinical Pharmacy, College of Pharmacy, Mustansiriyah University, Iraq.
author
text
article
2022
eng
Background: To assess the quality of life in Iraqi breast cancer women with regard to different Sociodemographic and medical variables. Methods: A cross sectional study was conducted on 150 women diagnosed with breast cancer and being treated in Iraq. The evaluation was done by using European Organization for Research and Treatment of Cancer Quality of Life Questionnaire- Core- 30 (EORTC QLQ-C30) and QOL_BR23 Questionnaire. All data were conducted directly via hand writing by the patients at the Oncology Teaching Hospital/Medical City complex in Baghdad. When the questionnaire questions were completed by each participant, they were checked up to ensure their suitability for data insertion and then followed by the scoring manual of the EORTC questionnaire. All the data were analyzed by using SPSS. Results: Most of the patients undergoing this study were at the age of ≤ 50 (52.66%), and when they were diagnosed with breast cancer, they were younger than 50 (58.66%). The global health status was high in the case of working participants compared with those who are unemployed, i.e., (p=0.035). However, the emotional status appeared to be significant in the case with the working participants (P= 0.027). Also, the global status appeared to be high in the participants receiving radiation, while it showed insignificant values with the other data. The physical functioning, on the other hand, showed significant results in many places, as in the case with the patients present with no health problems, and high results in radiation, herceptin and hormonal therapy. As for the role functioning, it showed significant results in patients without health problems, patients who underwent radiation, and patients who were free of disease for less than five yeas. Conclusions: The results of this study will help identify gaps in all areas in which patients need additional support. Since the negative effects of the disease and related treatments influenced the patient’s quality of life, it has become necessary for health care providers to focus on designing social and psychological interventions to support cancer patients throughout their illness and treatment in a way that it leads to a better adaptation to their disease and improve their emotional status.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2299
2307
https://journal.waocp.org/article_90215_e994d9f9097d7fcb193bed7fb06061e9.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2299
Iranian Mesobuthus Eupeus Crude Venom Induces Selective Toxicity in Chronic Lymphocytic Leukemia B-Lymphocytes Through Lysosomal/Mitochondrial Dysfunction and Reactive Oxygen Species Formation
Ahmad
Salimi
Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran.
author
Vahed
Adhami
Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran.
author
Seyyed Hossein
Sajjadi Alehashem
Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran.
author
Hossein
Vatanpour
Department of Pharmacology and Toxicology,
Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
author
Leila
Sadeghi
Department of Clinical Oncology, Imam
Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
author
text
article
2022
eng
From ancient times to the present-day animal venoms had been used as medicinal and therapeutic agents. Recently it has been reported that the scorpion venom is a potential source of active and therapeutic compounds to design potent drugs against variety of cancerous cells and other diseases. The current study aimed to evaluate the selective toxicity of Iranian Mesobuthus eupeus (IMe) crude venom as a potential source of anticancer compounds on cancerous CLL B-lymphocytes and normal lymphocytes. For this purpose, we isolated cancerous CLL B-lymphocytes and normal lymphocytes from chronic lymphocytic leukemia patients and healthy volunteers. Cancerous CLL B-lymphocytes and normal lymphocytes were treated with different concentration (0, 5, 10, 20, 40 and 80 µg/ml) of IMe crude venom for 12 hours and cytotoxicity, reactive oxygen species (ROS) production, collapse of mitochondrial membrane potential (MMP) and lysosomal membrane integrity were determined. The data demonstrated the significant cytotoxic effect of IMe crude venom on cancerous CLL B-lymphocytes, with a concentration value (IC50) that inhibits 50% of the cell viability of 60 µg/ ml after 12 h of incubation. MTT assay proved that the IMe crude venom is selectively toxic to cancerous CLL B-lymphocytes, and IMe crude venom induced selective cell death via activation of ROS formation and mitochondrial/lysosomal dysfunction. These finding showed that IMe crude venom has a selective mitochondrial/lysosomal-mediated cell death effect on cancerous CLL B-lymphocytes. Therefore, the IMe crude venom and its fractions may be promising in the future anticancer drug development for treatment of CLL and variety of cancers.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2309
2316
https://journal.waocp.org/article_90185_63dbe9ce678efe0cdde77b35b7451b1f.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2309
A Randomized Study of Short Course (One Week) Radiation Therapy with or without Temozolomide in Elderly and/or Frail Patients with Newly Diagnosed Glioblastoma (GBM)
Subhash
Thakur
Department of Radiation Oncology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
author
Narendra
Kumar
Department of Radiation Oncology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
author
Pravin
Salunke
Department
of Neurosurgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
author
Chirag
Ahuja
Department of Radiodiagnosis,
Post Graduate Institute of Medical Education and Research, Chandigarh, India.
author
Renu
Madan
Department of Radiation Oncology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
author
text
article
2022
eng
Objective: Short-course radiotherapy (25 Gy in 5 fractions) has been shown to be non-inferior to standard course radiotherapy in elderly and frail patients (60 Gy in 30 fractions). The purpose of this study was to determine the effects of temozolomide combined with short-course radiotherapy on the outcome of elderly and frail patients. Methods: Between January 2017 and November 2018, 90 patients (65 years old and KPS score of 50-70; 65 years old and KPS score of 80-100; and 65 years old and KPS score of 50-70) were assessed for eligibility. Nine patients were excluded because they did not meet the inclusion criteria, six patients declined to participate, and four patients were unable to complete the quality-of-life questionnaire. The remaining 71 patients were divided into two arms at random in a 1:1 ratio. Short-course radiotherapy with concurrent temozolomide and adjuvant temozolomide was given to Arm 1, while short-course radiotherapy alone was given to Arm 2. Results: In terms of overall survival and progression-free survival, radiotherapy with concurrent temozolomide and adjuvant temozolomide outperformed short-course radiotherapy alone. The median overall survival in arm 1 was 146 days and 121 days in arm 2 (P=0.146). The median progression-free survival in arm 1 was 109.50 days, while it was 77 days in arm 2 (P=0.028). With a median follow-up time of 6 months, the quality of life at 4 weeks and 12 weeks after treatment was not different between the two arms. Conclusion: We concluded that adding temozolomide to short-course radiotherapy significantly improved progression-free survival and showed an increasing trend in overall survival without compromising the quality of life.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2317
2323
https://journal.waocp.org/article_90186_ab0cc0cd959d0fde8649d06753f0e9f5.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2317
Clinical Features of Fecal Immunochemical Test-Negative Colorectal Lesions based on Colorectal Cancer Screening among Asymptomatic Participants in Their 50s
Shinya
Suto
Department of Gastroenterology and Haematology, Hirosaki University Graduate School of Medicine 5 Zaifu-cho, Hirosaki,
Aomori 036-8562, Japan.
author
Masashi
Matsuzaka
Department of Medical Informatics, Hirosaki University Hospital, 53 Honcho, Hirosaki, Aomori 036-
8563, Japan.
author
Manabu
Sawaya
Department of Gastroenterology and Haematology, Hirosaki University Graduate School of Medicine 5 Zaifu-cho, Hirosaki,
Aomori 036-8562, Japan.
author
Hirotake
Sakuraba
Department of Gastroenterology and Haematology, Hirosaki University Graduate School of Medicine 5 Zaifu-cho, Hirosaki,
Aomori 036-8562, Japan.
author
Tatsuya
Mikami
Innovation Center for Health Promotion, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-
8562, Japan.
author
Takahisa
Matsuda
Division of Gastroenterology and Hepatology, Toho University Omori Medical Center, 6-11-1 Omori-Nishi, Ota-ku,
Japan.
author
Takahiro
Fujii
TF Clinic, Ginza M&S building 7F, 4-13-11 Ginza, Chuo-ku, Tokyo 104-0061, Japan.
author
Yutaka
Saito
Endoscopy Division, National
Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
author
Kinichi
Hotta
Division of Endoscopy, Shizuoka Cancer Center, 1007
Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan.
author
Hiroaki
Ikematsu
Department of Gastroenterology and Endoscopy,
National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.
author
Norihiro
Hanabata
Department of Gastroenterology,
Aomori Prefectural Central Hospital, 2-1-1, Higashi-Tsukurimichi, Aomori 030-8553, Japan.
author
Hiroshi
Saito
Aomori Prefectural Central
Hospital, 2-1-1, Higashi-Tsukurimichi, Aomori 030-8553, Japan.
author
Shigeaki
Yoshida
Aomori Prefectural Central
Hospital, 2-1-1, Higashi-Tsukurimichi, Aomori 030-8553, Japan.
author
Shinsaku
Fukuda
Department of Gastroenterology and Haematology, Hirosaki University Graduate School of Medicine 5 Zaifu-cho, Hirosaki,
Aomori 036-8562, Japan.
author
text
article
2022
eng
Objective: To improve the efficacy of colorectal cancer (CRC) screening, decreasing the occurrence of interval cancers is essential. Most interval CRCs develop from fecal immunochemical test (FIT)-negative CRC. This study examined the clinical characteristics of FIT-negative advanced neoplasms (AN) and sessile serrated lesions (SSL), which are main candidate precursors of FIT-negative CRC, and the eligibility criteria for total colonoscopy (TCS) screening following negative FIT. Methods: Asymptomatic participants in their 50s were divided into two groups. The FIT-negative group underwent TCS following negative FIT, and the TCS-only group underwent TCS without FIT. One endoscopist reviewed the endoscopic images. Plausible risk factors for colorectal polyps were extracted. The clinical features of AN and SSL were compared between the groups. Result: Of 2,437 participants, 56.2% were included in the FIT-negative group. No between-group differences were recorded for the prevalence of different colorectal polyp types. By multivariate analysis, a significantly lower adjusted odds ratio (AOR) of AN was shown in women, and significantly higher AORs of AN were found for aging, smoking, and a family history of CRC. The AOR of SSL was higher for smokers. The proportion of AN in the right colon was higher in the FIT-negative group. No between-group differences were recorded for SSL. Conclusion: FIT screening was less likely to detect CRC and certain precancerous lesions in the right colon. Combining annual FIT with TCS for the high-risk population based on a scoring system, may detect FIT-negative CRC and colorectal polyps, thus, reducing interval cancer.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2325
2332
https://journal.waocp.org/article_90187_97c2e1bb4798cfe3fb3dfca37372f6dd.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2325
A Double-Blind, Placebo-Controlled Randomized Phase IIa Study: Evaluating the Effect of Curcumin for Treatment of Cancer Anorexia–Cachexia Syndrome in Solid Cancer Patients
Aornchuma
Chaiworramukkul
Division of Medical Oncology, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand.
author
Kasan
Seetalarom
Division of Medical Oncology, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand.
author
Siriwimon
Saichamchan
Division of Medical Oncology, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand.
author
Naiyarat
Prasongsook
Division of Medical Oncology, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand.
author
text
article
2022
eng
Objective: We aim to investigate the effect of curcumin on preventing cancer anorexia–cachexia syndrome (CACS) via through mechanism of inhibition on NF-kB signal pathway. Outcome measurement for primary end point was improvement of body tissue composition, and the secondary end points were body weight and body mass index, hand grip muscle strengthening, and safety. Methods: This is randomized, double-blind, placebo-controlled phase ll a study, 33 patients with CACS in solid malignancy were enrolled and randomized in 1:1 to receive oral curcumin (at a dose of 800 mg twice daily) or placebo for 8 weeks. Results: All parameters of body compositions were not statistically significant different between two groups, which were consist body fat mass [-1.25(SEM 0.87) vs. +0.63(SEM 0.55); p=0.119], skeletal muscle mass [-0.35(SEM 0.60) vs.+0.33(SEM 0.42); p=0.408] and percent body fat [-0.47(SEM 0.95) vs. -0.29(SEM 0.82); p=0.893] including with basal metabolic rate [-13.47(SEM 21.94) vs. +15.30(13.76); p=0.336]. The average of weight loss was also not statistically significant different between two groups. [-1.4 kg(SEM 0.89) in curcumin vs-1.12 kg(SEM 0.73), p=0.810]. Notably, patient with curcumin had less reduction of hand-grip muscle strength on both hands [Rt. handed: -2.47 in curcumin vs. -5.36 in placebo; p=0.318] [Lt. handed: -1.98 vs. -5.43; p=0.317], and basal metabolic rate than placebo group. Most adverse events were grade 1 on both groups similarly. Conclusion: Curcumin was not shown to be superior to placebo with regard to increasing the body composition in cancer patients with CACS. However, curcumin might show some clinical benefits, including slow progression of hand-grip muscle strength loss, and basal metabolic rate. Further investigations should be explored.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2333
2340
https://journal.waocp.org/article_90210_eb641c3e8bde7ef1e75a24224689f562.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2333
MDM2 is a Potential Target Gene of Glycyrrhizic Acid for Circumventing Breast Cancer Resistance to Tamoxifen: Integrative Bioinformatics Analysis
Salma
Azzahra
Laboratory of Macromolecular Engineering, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah
Mada Sekip Utara II, 55281 Yogyakarta, Indonesia.
author
Naufa
Hanif
Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas
Gadjah Mada Sekip Utara II, 55281 Yogyakarta, Indonesia.
author
Adam
Hermawan
Laboratory of Macromolecular Engineering, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah
Mada Sekip Utara II, 55281 Yogyakarta, Indonesia.
author
text
article
2022
eng
Background: Tamoxifen is the drug of choice for treating breast cancer, particularly the estrogen receptor-positive luminal A subtype. However, the increased occurrence of Tamoxifen resistance highlights the need to develop an agent to enhance the effectiveness of this drug. Objective: Although glycyrrhizic acid (GA) is known to exhibit cytotoxic effects on Michigan Cancer Foundation-7 cells, the specific gene targets and pathways it employs to overcome Tamoxifen resistance are incompletely understood. Therefore, the goal of the present research is to discover the potential targets and pathways of GA by using a bioinformatics approach. Methods: Differentially expressed genes (DEGs) were identified in the Gene Expression Omnibus NCBI database using microarray data from GSE67916 and GSE85871. Further analyses were performed on these DEGs by using DAVID v6.8, STRING-DB v11.0, and Cytoscape v3.8.0. Analysis of gene alterations was performed using cBioPortal for target validation, and the relevant interaction process was examined via the molecular docking method. Results: Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses identified the PI3K-AKT signaling as the potential target mechanism. Construction of the protein–protein interaction network and analysis of hub genes identified the top 25 hub genes. Genetic alterations were observed in six potential target genes, such as CDK2, MDM2, NF1, SMAD3, PTPN11, and CALM1. Molecular docking analysis demonstrated that the docking score of GA is lower than that of the native ligand of p53. More importantly, 3n the PI3K-AKT signaling pathway is a potential target for overcoming Tamoxifen resistance in breast cancer. Conclusion: MDM2 may be a potential gene target of GA and the PI3K-AKT signaling may be a prospective mechanism for overcoming Tamoxifen resistance in breast cancer cells. Additional research is required to validate the findings of this study.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2341
2350
https://journal.waocp.org/article_90188_a48e39d86493ba01cf77711f4937a4f9.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2341
High Frequency of Epstein-Barr Virus and Absence of Papillomavirus in Breast Cancer Patients from Brazilian Northeast
Emanuele
Oliveira
Pathology and Forensic Medicine Department, Federal University of Ceará, Fortaleza, CE, Brazil.
author
Márcia
Ferreira
Pathology and Forensic Medicine Department, Federal University of Ceará, Fortaleza, CE, Brazil.
author
Paula
Rahal
Laboratory of Genomic
Studies, Biology Department, São Paulo State University (UNESP), São José do Rio Preto, SP, Brazil.
author
Martan
Castelo Branco
Pathology and Forensic Medicine Department, Federal University of Ceará, Fortaleza, CE, Brazil.
author
Silvia
Rabenhorst
Pathology and Forensic Medicine Department, Federal University of Ceará, Fortaleza, CE, Brazil.
author
text
article
2022
eng
Objective: This study aimed to determine the presence of Epstein-Barr Virus (EBV) and Human papillomavirus (HPV) in breast cancer with patients from Northeast of Brazil, considering the molecular subtypes and also taking in account the relation with TP53 immunoexpression. Methods: Seventy-five samples of invasive breast carcinoma with no special type were selected from pathology archives at Federal University of Ceará. EBV was detected by In situ hybridization (ISH) and immunohistochemistry (IHC) and HPV was detected by PCR. ISH was performed using EBER1 probe (Shibata et al., 1991; Bacchi et al., 1996) while IHC was performed on histological formalin-fixed paraffin-embedded tissue samples (Hsu et al., 1981). PCR methodology (Haws et al., 2004) was used to amplify the genetic material of human papillomavirus. The amplification products were electrophoretic analyzed on 1% agarose gel. The data analyses were carried out using the statistical software EPINFO® version 6.04d and SPSS version 17.0 (SPSS Inc., Chicago, IL). Statistically significant differences were evaluated by the chi-square test and Fisher’s exact test and correlations between groups were analyzed by Spearman’s and Pearson’s rank correlation coefficient. Results: 69.4% of the cases were EBNA1 positives by IHC. EBNA1 positive tumors had lower Ki-67 index (0-40%), while EBNA1 negative cases had relevant higher Ki-67 index (41-100%) (p = 0.06). EBV was present in all tumor grades, with a high frequency in grade I and III tumors comparing to EBNA1 negative cases. No HPV positive cases were observed. Conclusion: Regarding the results from this study, we support the hypothesis that EBV can be involved on breast tumorigenesis.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2351
2359
https://journal.waocp.org/article_90191_c1663045a18240f322c249aceada26f4.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2351
Evaluation of an Interventional Health Education Project: Screening of Breast Cancer and Health Education (SHE)
Meenakshi
Khapre
Community and Family Medicine, AIIMS Rishikesh , India.
author
Bina
Ravi
Integrated Breast Care Centre (IBCC) All India Institute of Medical
Sciences, Rishikesh, India.
author
Prateek
Sharda
Integrated Breast Care Centre (IBCC) All India Institute of Medical
Sciences, Rishikesh, India.
author
Aparajita
Mehta
Community and Family Medicine, AIIMS Rishikesh , India.
author
Ranjeeta
Kumari
Community and Family Medicine, AIIMS Rishikesh , India.
author
text
article
2022
eng
There is an increasing incidence of breast cancer in India, especially among younger women. The study’s main objective was to create awareness related to breast cancer and breast self-examination by community health workers and assess the effectiveness of improving knowledge and practice. Secondary objective was to conduct clinical breast examination (CBE) of women and prompt referral. Methods: An outcome evaluation of the Educational Interventional project was conducted in a hilly district of Uttarakhand. Twenty Accredited Social Health Activists (ASHA) were identified and trained in breast cancer awareness, the procedure of breast self-examination, and screening methods. These ASHA’s further created awareness among study participants (women above 30 years). A structured questionnaire on knowledge and practice was administered before and after educational intervention by ASHA workers. Clinical Breast Examination (CBE) camps were held for women at high risk for breast cancer who were referred to the Division of Breast Surgery, AIIMS Rishikesh, for further management. Result: One thousand sixty-one females participated in health education sessions by ASHAs. There was an improvement in knowledge and practice regarding Breast Self-examination after health education intervention. A low prevalence of risk factors for breast cancer was found among attendees of the CBE camp. 3.2% of participants had abnormalities on breast examination needing further workup. Conclusion: In the pre-test assessment, we found a low awareness and practice regarding breast cancer which increased significantly among women after behavioral change intervention. The prevalence of risk factors for breast cancer was very low. Trained community health workers were found to be effective in raising awareness, selective screening, and prompt referral.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2361
2366
https://journal.waocp.org/article_90189_9bd899629587f15afac3eab1c1577d12.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2361
A Comparison of Two Scales to Determine Prevalence of Mood Disorders in Omani Patients Recently Diagnosed with Cancer
Ikram A
Burney
Department of Medicine, Sultan Qaboos University Hospital, College of Medicine and Health Sciences, Sultanate of Oman.
author
Zena M
Al-Sharbati
Department of Behavioural Medicine, Sultan Qaboos University Hospital, College of Medicine and Health Sciences, Sultanate
of Oman.
author
Zainab
Al-Rawahi
Department of Medicine, Sultan Qaboos University Hospital, College of Medicine and Health Sciences, Sultanate of Oman.
author
Somaia
Al-Hatmi
Department of Medicine, Sultan Qaboos University Hospital, College of Medicine and Health Sciences, Sultanate of Oman.
author
Syed G
Rizvi
Department of Family Medicine & Public Health Sultan Qaboos University Hospital, College of Medicine and
Health Sciences, Sultanate of Oman.
author
Mohamed-Rachid
Boulassel
Department of Allied Health Sciences, Sultan Qaboos University, Muscat, Oman.
author
text
article
2022
eng
Objectives: Studies on the prevalence rate of mood disorders in patients recently diagnosed with cancer from Middle East are scare in the literature. Therefore, this study assesses the prevalence rates of anxiety and depression, and their associations with socio-demographic factors, in recently diagnosed patients with cancer living in the Sultanate of Oman. Methods: In this prospective study, adult patients were interviewed within the first three months of diagnosis of cancer using the Hospital Anxiety and Depression Scale (HADS), and the Centre for Epidemiological Studies Depression (CES-D) Scale. Associations were studied among symptoms of anxiety and depression, and the socio-demographic factors, along with levels of agreement between the two scales. Results: Eighty-nine patients were interviewed, and 65% were females. Using the HADS tool, 41.6% of patients had anxiety, 28% had depression, whereas 5.6% displayed severe depression. Using the CES-D tool, 41.6% of patients had depression, and 11.2% had severe depression. A fair correlation between the CES-D and HADS tools was evidenced with a Cohen’s Kappa coefficient value of 0.37 (P<0.001). The socio-demographic factors were not significantly associated with the presence of anxiety and depression (P >0.05). Conclusion:Collectively, these findings indicate high prevalence rates of anxiety and depression in Omani patients recently diagnosed with cancer along with a significant correlation between the two scales. These results support the implementation of screening tools early in the trajectory of cancer illness to improve the overall healthcare of these patients.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2367
2373
https://journal.waocp.org/article_90216_3d31a7609e3875262ac4586452ec19ea.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2367
In Patients with Acute Ischemic Stroke and Cancer: The Shorter Interval, the Higher D-Dimer
Xin-Kun
Wang
Department of Radiology,Chinese PLA General Hospital, China.
author
Min-Hang
Zhou
Department of Oncology, the Second Medical Center &
National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, China.
author
text
article
2022
eng
Objectives: Acute ischemic stroke in cancer patients is uncommon. The study was aimed to identify the relationship of patients’ characteristics and the interval time between the diagnosis of stroke and cancer. Methods: The clinical features of acute ischemic stroke patients with cancer were retrospectively analyzed from May, 2016 to April, 2021. Categorical data was compared between groups using chi-square test. Hematological biomarkers were compared using Mann-Whitney U test. Results: A total of 70 acute ischemic stroke patients with cancer were identified. The median interval time between the diagnosis of acute ischemic stroke and cancer was 53.0 months. Patients with interval < 53.0 months and > 53.0 months were regarded the short interval group and the long interval group, respectively. Between the short and long interval groups, there was no significant differences in respect to sex, age, chemotherapy, hypertension, diabetes, smoking, atrial fibrillation and dyslipidemia. The medians of homocysteine, high-sensitivity C-reactive protein and fibrinogen were also not significantly different between the two different interval groups. D-dimer in the short interval group was higher than that in the long interval group (216 vs. 142 ng/mL, p = 0.037). The long interval group had more surgery for cancer than the short interval group (94.3% vs. 57.1%, p = 0.000). Conclusion: In conclusion, in patients with ischemic stroke and cancer, patients with short interval time between the diagnosis of ischemic stroke and cancer had higher D-dimer than patients with long interval time.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2375
2378
https://journal.waocp.org/article_90190_3eadfe2765cdcbcd644f8ca0afe94a34.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2375
Phyllanthus taxodiifolius Beille Disrupted N-cadherin, Vimentin, Paxillin and Actin Stress Fibers in Glioblastoma
Chotchanit
Sunrat
Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
author
Jaturon
Kwanthongdee
Princess Srisavangavadhana College
of Medicine, Chulabhorn Royal Academy, Bangkok, Thailand.
author
Kwanchanok
Uppakara
Chakri Naruebodindra Medical Institute, Faculty of Medicine
Ramathibodi Hospital, Mahidol University, Bangpla, Bangpli, Samutprakarn, Thailand.
author
Napason
Chabang
School of Bioinnovation and Bio-based
Product Intelligence, Faculty of Science, Mahidol University, Bangkok, Thailand.
author
Bamroong
Munyoo
Excellent Center for Drug Discovery (ECDD),
Faculty of Science, Mahidol University, Bangkok, Thailand.
author
Patoomratana
Tuchinda
Excellent Center for Drug Discovery (ECDD),
Faculty of Science, Mahidol University, Bangkok, Thailand.
author
Witchuda
Saengsawang
Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
author
text
article
2022
eng
Objective: Glioblastoma is the most aggressive and lethal brain tumor in adults with highly invasive properties. In this present study, we explored the effects of Phyllanthus taxodiifolius Beille extract on molecules known to be hallmarks of aggressive glioblastoma including N-cadherin and vimentin, mesenchymal markers, as well as paxillin, a major adaptor protein that regulates the linking of focal adhesions to the actin cytoskeleton. Methods: P. taxodiifolius were air-dried, powdered and percolated with methanol, filtered, concentrated and lyophilized to yield a crude methanol extract. C6 glioblastoma cell line was used in this study. The expression of N-cadherin and vimentin, as well as the activation of paxillin was determined using Western blot analysis. The effect of the extract on focal adhesions and actin cytoskeleton were investigated using immunofluorescence staining and confocal imaging. Results: In the presence of 40 µg/ml Phyllanthus taxodiifolius Beille extract, the expression of N-cadherin and vimentin were significantly decreased (p<0.001 and p<0.05, respectively). Activation of paxillin was also diminished as indicated by a reduction of phosphorylated-paxillin (p<0.01). Consequently, actin stress fibers in glioblastoma cells were abolished as evidenced by the decrease in focal adhesion (p<0.001) and stress fibers numbers (p<0.001). Conclusion: Our study demonstrates for the first time that P. taxodiifolius interferes with multiple key molecules related to pathological hallmarks of glioblastoma. These molecules are involved with cell contacts, focal adhesions, and the formation and stabilization of actin stress fibers, which are required for glioblastoma metastatic behavior. These results provide further evidence supporting the potential of P. taxodiifolius and its bioactive compounds as anti-cancer agents.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2379
2386
https://journal.waocp.org/article_90193_2b472c496433225830a6e6f5c3d24e36.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2379
Novel Approach using shRNA of IQGAP1 for Colon Cancer Therapy: HCT116 as a Surrogate Model Colorectal Carcinoma
Khairy M
Zoheir
Cell Biology Department, Biotechnology Research Institute, National Research Centre, 33 Bohouth St., 12622, Dokki, Cairo, Egypt.
author
khaled
Mahmoud
Pharmacognosy Department, National Research Centre, El-Behooth St., 12622 Dokki, Cairo, Egypt.
author
Gamal
Harisa
Pharmaceutical Industries, Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
author
Abdelkader
Ashour
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Sinai University, 41636 Kantara Branch, Egypt.
author
Hala
Abdel-Hamied
Department of Pharmacology and Toxicology, College of Pharmacy, Al-Azhar University, Cairo, Egypt.
author
Amro
Amara
Protein Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications, Alexandria, Egypt.
author
Karima
Mahrous
Cell Biology Department, Biotechnology Research Institute, National Research Centre, 33 Bohouth St., 12622, Dokki, Cairo, Egypt.
author
Ahmed A
Abd-Rabou
Hormones Department, Medicine and Clinical Studies Research Institute, National Research Centre, Cairo, 12622 Egypt.
author
text
article
2022
eng
Background: Colorectal carcinoma (CRC) represents life-threatening problems worldwide. IQ motif containing GTPase activating protein 1 (IQGAP1) is acting as oncogenesis regulators. RNAi is proposed as promising cancer therapeutics. Objective: The objective of this work to explore the consequences of the IQGAP1 silence as a goal for treating CRC using the HCT166 cells as a model for human colon cancer. Methods: RNAi technology was used to design a short specific sequence of RNA (shRNA) to silence the IQGAP1 oncogene. The impact of IQGAP1 silencing on IQGAPs, Ras, IL-8, and TRAIL was investigated. Furthermore, the effect of IQGAP1 silencing on cell viability, proliferation, apoptosis, and invasive capacity was investigated. Results: The present results revealed that IQGAP1 shRNA-treated HCT166 cells showed no invasive capacity compared to the control cells. The silencing of IQGAP1 induced remarkable downregulation of IQGAP1, RAS (H&K), IL-8, CXCR1, CXCR2, NF-kB, BCL-2, and apoptosis of HCT166 cells. On the contrary, IQGAP2, IQGAP3, DR4, DR5, CASP-3, and BAX genes were significantly up-regulated. Conclusion: The IQGAP1 regulates the expression of IQGAPs, Ras, IL-8 receptors, and the apoptotic network. Therefore, the silence of IQGAP1 is a promising strategy for colon cancer therapy.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2387
2395
https://journal.waocp.org/article_90194_291491ffb3af28f96670bdee0cf96fdf.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2387
Association between the Number of Repeated Praziquantel Treatments and Kidney Parenchymal Change in Northeast Thailand
Panuwat
Prathumkam
Epidemiology and Biostatistics Program, Faculty of Public Health, Khon Kaen University, Khon Kaen, 40002, Thailand.
author
Kavin
Thinkhamrop
Data Management and Statistical Analysis Center (DAMASAC), Faculty of Public Health, Khon Kaen University, Khon
Kaen, 40002, Thailand.
author
Narong
Khuntikeo
Cholangiocarcinoma Screening and Care Program (CASCAP), Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002,
Thailand.
author
Nittaya
Chamadol
Cholangiocarcinoma Screening and Care Program (CASCAP), Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002,
Thailand.
author
Jaruwan
Thuanman
Cholangiocarcinoma Screening and Care Program (CASCAP), Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002,
Thailand.
author
Matthew
Kelly
Department of Global Health, Research School of Population
Health, Australian National University, Canberra, ACT, 2601, Australia.
author
Bandit
Thinkhamrop
Cholangiocarcinoma Screening and Care Program (CASCAP), Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002,
Thailand.
author
text
article
2022
eng
Background: In Northeast Thailand, Praziquantel (PZQ) is used to treat infection with the Opisthorchis viverrnini (OV). OV has highly prevalence in this area due to the traditional consumption of uncooked cyprinid fish. The nephrotoxic effects of PZQ metabolite excretion through the kidney have not been assessed yet. This study investigated the relationship between number of Praziquantel treatments and kidney parenchymal change. Methods: A study was carried out on participants from the Cholangiocarcinoma Screening and Care Program (CASCAP) between 2013 - 2018. The frequency of PZQ use was reported using a standardized questionnaire. Kidney parenchymal change (KPC) was defined as having a kidney abnormality based on ultrasonography diagnosed by well-trained general practitioners. Adjusted odds ratios (ORs) measured associations between PZQ frequency and KPC controlling for the effects of other extraneous factors using multiple logistic regression. Results: A total of 490,969 subjects with mean age of 55.2 (SD = 9.15) years were enrolled among them 62.1% were female. Prevalence of KPC was 1.2% while prevalence of KPC were 1.2%, 1.3%, 1.4%, and 1.5% for participants with one, two, three, and more than 3 PZQ treatment occasions respectively. Those dose-response relationship was statistically significant based on chi-square test for trend (p-value <0.001). After controlling for possible confounders, compared to non-treatment, subjects with more than 3 treatment occasions were 25% more likely to have a KPC positive result (OR = 1.25; 95% CI: 1.02 - 1.52; p-value = 0.028). Conclusion: The number of repeated PZQ treatments is statistically significantly related to KPC. This relationship could be included in health messaging for those who continue eating uncooked fish with an understanding that the OV infection can easily be cured by PZQ without any other health concerns. For positive OV cases, however, the known efficacy of PZQ could over-ride the small magnitude of the adverse effect.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2397
2405
https://journal.waocp.org/article_90196_66a0e4b79f25a2acbab03b7e2497cc28.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2397
Analysis of Rapid arc-based Radiation Therapy on Dosimetric Parameters in Cervical Cancer Patients with and without Bone Marrow Sparing
Ritu
Aggarwal
Department of Radiation Oncology, DMCH Cancer Care Center, Ludhiana, Punjab, India.
author
Sandhya
Sood
Department of Radiation Oncology, DMCH Cancer Care Center, Ludhiana, Punjab, India.
author
Manjinder
Singh
Department of Radiation Oncology, DMCH Cancer Care Center, Ludhiana, Punjab, India.
author
Kulbir
Singh
Department of Radiation Oncology, DMCH Cancer Care Center, Ludhiana, Punjab, India.
author
Divyanshi
Sood
Department of Radiation Oncology, DMCH Cancer Care Center, Ludhiana, Punjab, India.
author
Vipin
Mupasana
Department of Radiation Oncology, DMCH Cancer Care Center, Ludhiana, Punjab, India.
author
Mohandass
Palanisamy
Department of Radiation Oncology, Fortis Cancer Institute, Fortis Hospital, Mohali, Punjab, India.
author
text
article
2022
eng
Background: The standard treatment for cervical cancer is chemoradiation therapy. Pelvic radiation is associated with higher dose to bone marrow (BM) causing interrupted treatment due to haematologic toxicity with inferior outcomes. This study aims to evaluate rapid arc technique in sparing pelvic BM and dosimetric parameters for pelvis V5GY, V10GY, V20GY, V30GY, and V40GY dose. Method: Twenty one cervical cancer patients were selected for the analysis. Planning target volume (PTV) contours, total pelvic BM and surrounding structures contours were standardised. Two rapid arc based procedures were designed for individual patient. One was done using bone marrow sparing (BMS) constraints while other was performed without BMS constraints. Data for both plans was calculated with regard to PTV, normal structures and pelvic BM. Difference in dose distribution in both groups was analysed using Wilcoxon and Friedman ANOVA test. Results: In the presence of BM constraint a significant changes in pelvic BM dose for values of V10GY (p=0.002), V20GY (p=0.002) and V40GY (p=0.025) was observed. The coverage of PTV was found to be unaffected by adding BM constraint. Conclusion: The BM is radiosensitive structure so dosage is linked with haemtological toxicity. Increased dose is associated with higher grade of haematological toxicity in pelvic radiotherapy. The study suggests that adding BM constraint in plans reduced the pelvic BM dose while not affecting PTV coverage and dose to bowel, bladder and rectum. Bone marrow constraint in pelvic radiotherapy can be considered for better treatment toleration and to determine its role in decreasing haematological toxicity.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2407
2413
https://journal.waocp.org/article_90195_f0d4ac6e9bc724bac17fe673d037d27b.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2407
Treatment Delay during Radiotherapy of Cancer Patients due to COVID-19 Pandemic
Swarupa
Mitra
Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
author
David
Simson
Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
author
Himanshi
Khurana
Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
author
Sarthak
Tandon
Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
author
Parveen
Ahlawat
Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
author
Nitin
Bansal
Department of Infectious
Diseases, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
author
Soumitra
Barik
Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
author
Jaskaran
Sethi
Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
author
Kundan
Chufal
Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
author
Munish
Gairola
Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
author
text
article
2022
eng
Purpose: To analyze the impact of treatment delay caused by COVID-19 infection on patients scheduled for radiotherapy treatment. Methods and Materials: In this descriptive study, we analyzed all patients who were COVID-19 positive during the scheduled radiotherapy course, those who had an infection while on neoadjuvant treatment period, or during surgery before the start of radiation. The study period was from June 2020 to May 2021. A treatment delay was defined as a delay in starting the radiation treatment, a gap during their scheduled radiation treatment, or treatment discontinuation. All patients who had a treatment delay were followed-up till November 2021. Results: The median follow-up time of the study was 13 months. Ninety-four patients were selected for the study who met the inclusion criteria. Seventy-seven patients had a mild COVID-19 infection, while 17 had a moderate to severe illness. Of the entire cohort, 83 patients had a treatment delay. The median treatment delay (MTD) in days was 18 (6 to 47). Amongst those who had a treatment delay, 66 patients were treated with curative intent, of which 51 patients are on follow-up – 34 patients are disease-free (MTD – 18.5, 10 to 43), seven had either a residual disease or locoregional recurrence (MTD – 22, 10 to 32), seven had distant metastasis (MTD – 18, 15 to 47), and three patients died (MTD – 20, 8 to 27). Of three patients who died, only one died of COVID-19-related causes. Conclusions: Even though the mortality due to COVID-19 infection among those who underwent radiotherapy was low, a treatment delay might have caused adverse treatment outcomes. Longer follow-up of these patients is required to further establish this. It will remain debatable whether it was worth delaying radiotherapy for mild to moderate COVID-19 infection for a significant time to cause a potential cancer treatment failure.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2415
2420
https://journal.waocp.org/article_90198_ca19dcef385a41845ed0cb04305db24f.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2415
Molecular Docking and in silico Pharmacological Screening of Oleosin from Cocos Nucifera Complexed with Tamoxifen in Developing Potential Breast Chemotherapeutic Leads
Janeea Myles
Dela Cruz
Department of Biochemistry, Faculty of Pharmacy, University of Santo Tomas, Manila Philippines.
author
Sophia Allison
Dones
Department of Biochemistry, Faculty of Pharmacy, University of Santo Tomas, Manila Philippines.
author
Rianne
Villanueva
Department of Biochemistry, Faculty of Pharmacy, University of Santo Tomas, Manila Philippines.
author
Alexis
Labrador
Department of Biochemistry, Faculty of Pharmacy, University of Santo Tomas, Manila Philippines.
author
Myla
Santiago-Bautista
Department of Biochemistry, Faculty of Pharmacy, University of Santo Tomas, Manila Philippines.
author
text
article
2022
eng
Objective: Tamoxifen is a widely used drug for breast cancer therapy; however, concerns and controversies regarding its efficiency arise as it induces various side effects, including endometrial cancer. This study aimed to assess the application of Oleosin as a potential protein carrier of Tamoxifen by evaluating the pharmacokinetic and pharmacological properties of Tamoxifen and determining its intermolecular interactions with Oleosin through in silico techniques. Methods: The pharmacokinetic and pharmacological properties of Tamoxifen were assessed by using predictive applications such as SwissADME, PaccMann, and Way2Drug. On the other hand, Oleosin does not have a crystal structure in PDB. Thus, homology modeling was done through SWISS-MODEL to obtain a structure. The interactions between Oleosin (Accession no.: AZZ09171.1) and Tamoxifen (PubChem ID: 2733526) were studied by performing molecular docking using AutoDock4 to determine their feasibility as breast cancer drug combinations. Result: The chosen structure of Oleosin from the homology modeling resulted in an RMSD of 1.80Å. Tamoxifen was predicted to have the highest activity in MCF7 cell lines, direct interaction with cytochrome enzymes, mediated interaction with estrogen receptors and tyrosine-protein kinase FYN, and low toxicity hazards based on the acute rat toxicity assay. It has lowest binding affinity of -5.26 kcal/mol. The hydrophobic (Ala106, Leu77, Ile80, Val84, and Tyr81) and electrically charged (Lys107 and Asp108) amino acids were critical in binding in the Oleosin-Tamoxifen-complex. Heatmap revealed that phenyl, ether, amine, and alkenyl are the functional groups involved in the receptor-ligand interactions. Conclusion: The application of Oleosin as a potential drug carrier was demonstrated by assessing the intermolecular interactions between the Tamoxifen and Oleosin through molecular docking. The properties of Tamoxifen revealed that the molecular targets impact the efficiency and the mechanism of action of the drug. This can also be the basis for investigating and determining the serious adverse effects induced by the drug.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2421
2430
https://journal.waocp.org/article_90197_f06ff4caae35c9ca943e7b059155d293.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2421
Expression of CD44v6 and RCAS1 in Uterine Cervical Carcinoma Infected with Human Papillomavirus and Its Effect on Cell Proliferation and Differentiation
Supaporn
Suwiwat
Department of Pathology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
author
Kobkul
Tungsinmunlong
Pathology Diagnostic Center.
1011/2 Arun Ammarin Road, Siriraj, Bangkoknoi, Bangkok, Thailand.
author
Sumalee
Siriaungkul
Department of Pathology, Faculty of Medicine, Chiang Mai
University, Chiangmai, Thailand.
author
text
article
2022
eng
Objective: To investigate the expression of CD44v6 and RCAS1 and the presence of HPV in cervical cancer tissues, to determine serum RCAS1 levels, and to evaluate these components in correlation with clinicopathologic features and survival. Methods: A total of 52 patients consisting of 28 squamous cell carcinoma (SCC) and 24 adenocarcinoma cases, were studied. RCAS1 and CD44v6 expression was evaluated using immunohistochemical staining. HPV 16 and 18 E6 genes were detected using PCR, and serum RCAS1 concentrations were measured using ELISA. Associations between these factors and clinicopathologic features and survival were analyzed. Results: CD44v6 expression was significantly higher in SCC compared with that in adenocarcinoma (P<0.001). It also showed a significant relation to histologic grade (P<0.001) and tumor size (P=0.03). RCAS1 expression was higher in adenocarcinoma than in SCC (P=0.001), and it showed a borderline relation with histological grade (P=0.057). Overall survival was not significantly different in both CD44v6 and RCAS1 expression; however, FIGO stage (P=0.025) and tumor size (P=0.042) resulted statistically different. The pre-surgical treatment serum RCAS1 levels were not associated with any clinicopathological variables. The presence of HPV 16 E6 was higher in SCC, while the presence of HPV 18 E6 was higher in adenocarcinoma (P<0.001). Detection of HPV 16 E6 was significantly associated with expression of CD44v6. The presence of HPV both HPV 16 E6 and HPV 18 E6 was found in cancer tissues with RCAS1 expression, but without any statistical significance. Conclusion: CD44v6 and RCAS1 expression seems to be involved in tumor proliferation and differentiation, but it is not implicated in the progression and invasion of cervical cancer infected by HPV. Pre-treatment levels of serum RCAS1 in cervical cancer are not a diagnostic and predictive biomarker.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2431
2439
https://journal.waocp.org/article_90199_e9c740780546f3e84a2b181bb7dd4c05.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2431
Does Trastuzumab Offer Good Value for Money for Breast Cancer Patients with Metastasis in Indonesia?
Erna
Kristin
Department of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Indonesia.
author
Dwi
Endarti
Department of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Indonesia.
author
Levina
Khoe
Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
author
Woro
Pratiwi
Department of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Indonesia.
author
Rizaldy
Pinzon
Clinical Epidemiology
& Biostatistics Unit, Faculty of Medicine, Gadjah Mada University, Indonesia.
author
Ratih
Febrinasari
Department of Pharmacology, Faculty of
Medicine, Sebelas Maret University, Indonesia.
author
Alfi
Yasmina
Department of Pharmacology and Therapeutics, Faculty of Medicine, Lambung
Mangkurat University, South Kalimantan, Indonesia.
author
Dwi Aris Agung
Nugrahaningsih
Department of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Indonesia.
author
Kartika
Taroeno-Hariadi
Department Internal Medicine, Faculty of Medicine, Universitas Gadjah
Mada/Dr Sardjito Hospital, Yogyakarta, Indonesia.
author
Ramadhan
Karsono
Department of Surgical Oncology, Dharmais National Cancer Center
Hospital, Indonesia.
author
I Wayan
Sudarsa
Department of Surgery, Faculty of Medicine, Udayana University/Sanglah General Hospital, Indonesia.
author
Muhammad
Prenggono
Faculty of Medicine, Lambung Mangkurat University/Ulin General Hospital, Indonesia.
author
Eva
Herlinawaty
Center for Financing and Health
Insurance, Ministry of Health, Indonesia.
author
Kalsum
Komaryani
Center for Financing and Health
Insurance, Ministry of Health, Indonesia.
author
Budi
Hidayat
Faculty of Public Health, Universitas Indonesia, Indonesia.
author
Mardiati
Nadjib
Faculty of Public Health, Universitas Indonesia, Indonesia.
author
text
article
2022
eng
Objective: Breast cancer is the most common cancer in Indonesia, with Indonesia’s breast cancer mortality rate being the highest among Southeast Asian countries. This study aims to evaluate the cost-effectiveness and budget impacts of adding trastuzumab to chemotherapy versus chemotherapy alone for HER2-positive breast cancer patients in Indonesia. Methods: We performed a Markov model-based economic evaluation to assess cost-effectiveness, cost–utility, and budget impact. Utility data, direct medical costs, and indirect costs were obtained primarily from interviewing patients. Clinical effectiveness data, on the other hand, were obtained from systematic reviews and real-world data and represented through progression free survival, overall survival, and quality-adjusted life years (QALYs). Result: From a healthcare provider’s perspective, the total costs for the combined group were USD 14,516, while chemotherapy alone cost USD 7,489. While the cost-effectiveness analysis showed that the combination group had a higher total cost by USD 7,027, PFS was longer in the chemotherapy alone group, with a difference of 2.2 months. The ICER was USD 17,307 for every QALY gained. The total cost of adding trastuzumab over a 5-year period was USD 589 million. Conclusion: In conclusion, this economic evaluation suggests that the addition of trastuzumab to standard chemotherapy is not cost-effective in terms of PFS and OS compared with chemotherapy alone.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2441
2447
https://journal.waocp.org/article_90219_505c5a1274b060655502b0e642165b8c.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2441
The Role of Pretherapeutic Diffusion-Weighted MR Imaging Derived Apparent Diffusion Coefficient in Predicting Clinical Outcomes in Immunocompetent Patients with Primary CNS Lymphoma: A Systematic Review and Meta-Analysis
Rahmad
Mulyadi
Department of Radiology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
author
Handoko
Handoko
Faculty of Medicine, Universitas Indonesia,
Jakarta, Indonesia.
author
Ramdinal
Zairinal
Faculty of Medicine, Universitas Indonesia,
Jakarta, Indonesia.
author
Joedo
Prihartono
Department of Community Medicine Pre Clinic, Faculty of
Medicine, Universitas Indonesia, Jakarta, Indonesia.
author
text
article
2022
eng
Objective: This systematic review and meta-analysis aimed to confirm the role of Apparent Diffusion Coefficient (ADC) values in predicting the prognosis of PCNSL patients based on previous studies. Methods: A systematic review with meta-analysis was conducted on related articles PubMed, Scopus, Sciencedirect, Cochrane, DOAJ, and Embase databases with last updated search on November 30, 2021. This systematic review and meta-analysis included a total of four studies. Result: All studies that examined the association between pretherapeutic ADC values and OS and PFS discovered that lower ADC values were associated with significantly shorter OS and PFS. The analysis revealed that patients with low ADC values had a higher risk of death than those with high ADC values, with a pooled HR of 0.24 (95% CI: 0.10–0.56; Z = 3.26; p = 0.001). A meta-analysis of five data from three studies examining the association between ADC values and PFS was also conducted using a fixed-effects model due to the low heterogeneity values (I2 = 4%; p = 0.38). The data analysis revealed that the pooled HR was 0.25 (95% confidence interval [CI]: 0.14–0.44, Z = 4.18; p 0.00001). Conclusion: Patients with low ADC values had significantly shorter overall survival and progression-free survival than those with high ADC values, so ADC values assessment prior to initial therapy administration can provide clinicians with valuable information about the prognosis of PCNSL.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2449
2457
https://journal.waocp.org/article_90218_42d91425ad2ed4e68b9c4bab65ae4d4d.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2449
A Comparative Evaluation of Cancer Classification via TP53 Gene Mutations Using Machin Learning
dina
Mikhail
Information System Engineering Department, Technical Engineering College, Erbil Polytechnic University, Erbil, Iraq.
author
Firas
Al-Mukhtar
Department of Information Technology & Computer science, Catholic University in Erbil, Iraq.
author
Shahab
Kareem
Department of Information Technology, College of Engineering and Computer Science, Lebanese French University, Erbil, Iraq.
author
text
article
2022
eng
Objective: Cancer is one of the horrendous diseases. Classifying cancer is founded on identifying cancer-causing mutations in gene sequences. Although genetic analysis can predict certain types of cancer, there is currently no effective method for predicting cancers. Therefore, the purpose of this paper is to predict the cancer types and to find a data mining technique that uses two different machine learning algorithms for classifying cancer. Moreover, earlier detection of the mutated tumor protein P53 gene can predict treatment and gene therapy techniques. Methods: (UMD-2010) the Universal Mutation Database is used to diagnose mutations in genes. The challenge, however, is that the database very basic. Besides, it is an excel format database. Due to its limitations, the data base cannot be used to classify cancer. In addition, bioinformatics techniques such as pairwise alignment and BLAST are used, followed by machine learning algorithms that use neural network algorithms to classify cancer based on malignant mutations in the TP53 gene, by selecting (12) out of (53) database fields for the TP53 gene database in the second stage. It should be noted that the (UMDCell-line2010) database does not have one of these twelve fields (Field of gene locus). Result: As a Utilizing MLP and SVM for training and testing a set number of fields, the Machin learning methods were found to be an effective way to classify cancers. Where the Relative Absolute Error for MLP and SVM is 83.6005 % ,65.6605 %, the accuracy is 90 %, 93.7% respectively. Conclusion: Following the learning and testing stages, the mean absolute error (MAE), used to measure the errors was found in the SVM less than the (MAE) in MLP algorithm. we can conclude that using SVM is considered better than the MLP algorithm because the accuracy in SVM better than the accuracy of MLP.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2459
2467
https://journal.waocp.org/article_90201_0eca2e6f89c2e3bafbcf619bd4c8a5fe.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2459
Modifiable (Sleeping Pattern and Stress) and Non-Modifiable Risk Factors Associated with Breast Cancer: A Matched Case-Control Study in Delhi, India
Gayatri
Vishwakarma
Indian Spinal Injuries Centre, New Delhi, India.
author
Anurag
Mehta
Department of Laboratory Services, Director Laboratory Services and Director Research, Rajiv Gandhi Cancer Institute, Research Centre, Delhi, India.
author
Mumtaz
Saifi
Molecular Diagnostics, Rajiv Gandhi Cancer Institute Research Centre, India.
author
Disha
Garg
Indian Spinal Injuries Centre, New Delhi, India.
author
Deepika
Paliwal
Department of Laboratory Services, Director Laboratory Services and Director Research, Rajiv Gandhi Cancer Institute, Research Centre, Delhi, India.
author
text
article
2022
eng
Background: An utmost increase of breast cancer burden during the last several decades was reported in Asian countries. Findings from literature confirm that risk factors of breast cancers can be modifiable and non-modifiable in nature. Objective: The present study is designed to identify specific modifiable and non-modifiable risk factors associated with breast cancer. Methods: A matched case-control study was conducted considering 187 cases as women diagnosed with breast cancer and 187 hospital-controls as women without having breast cancer visiting the hospital. Other than standard risk factors, stress is measured using Perceived Stress Scale (PSS) and stress is measured using Pittsburgh Sleep Quality Index (PSQI). Several modifiable and non-modifiable risk factors were assessed using conditional logistic regression to find out significant association with breast cancer. Results: Regular multi-vitamin uptake (OR = 3.38; 95%CI = 1.69 – 6.77; p-value = 0.001), poor sleep (OR = 11.29; 95%CI = 4.36 – 29.25; p-value < 0.001), irregular sleep (OR = 34.11; 95%CI = 10.03 – 115.92; p-value < 0.001) and severe stress (OR = 6.74; 95%CI = 3.06 – 14.81; p-value < 0.001) were found to be the highest odds ratio among all modifiable risk factor of breast cancer. Also, age at first childbirth less than 30 years (OR = 0.44; 95%CI = 0.25 – 0.78; p-value = 0.005) was found protective against breast cancer. Conclusion: In our study, stress, sleeping pattern, and regular multi-vitamin uptake were found to be significant modifiable risk factors of breast cancer. None of the non-modifiable risk factors were found to be significantly associated with the risk of breast cancer.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2469
2476
https://journal.waocp.org/article_90202_45a075a0c4aec0052247d36dbf431628.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2469
Genotype Distribution and Prevalence of High-Risk Human Papillomavirus Infection among Women in Samsun Province of Turkey
Mehmet
Taskin
Department of Medical Microbiology, Samsun University, Faculty of Medicine, Samsun, Turkey.
author
Ayse
Nursal
Department of Medical Genetics, Hitit University, Faculty of Medicine, Corum, Turkey.
author
Muhammet
Oruc
Department of Family Medicine, Ahi Evran University, Faculty of Medicine, Kirsehir, Turkey.
author
Ergin
Kariptas
Department of Medical Microbiology, Samsun University, Faculty of Medicine, Samsun, Turkey.
author
text
article
2022
eng
Background: The human papillomavirus (HPV) is an important public health problem that can cause cervical cancer. HPVs were classified into high-risk (HR-HPV) and low-risk (LR-HPV) types. In this study, we aimed to determine the prevalence and genotype distribution of HR-HPV infection in Samsun province in Turkey. Methods: Cervical smear samples taken from 5406 women over a 23-month period were evaluated for the presence of HPV infection. The detection of HPV genotypes was performed using RT-PCR technology. HPV detection and genotyping were performed using RT-PCR method. HR- HPV types are divided into 3 groups as type 16, type 18 and other types (31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, with or without type 16 and 18). The results were evaluated statistically. Results: The mean age of HR-HPV positive patients was 39.56 years (20-68 years). The prevalance of HR-HPV types did not differ between different age groups (p˃0.05). Overall, 9.17% of women (496/5406 samples) were found to be positive at least one type of HR-HPV. HPV type 16 was detected in 28.62%, type 18 in 9.67%, and other types in 78.83%. The most common HR-HPV type was other types (p˂0.001). Type 16 was most common than type 18 (p˂0.001). The patients were evaluated by dividing them into 6 age groups. Type 16 positivity was higher in 30-39 ages while type18 and other types positivity were higher in the 40-49 age group. When the 23-month period of HPV test was evaluated according to months and seasons, the highest prevalance was seen in June 2021 and Summer 2021. Conclusion: To our knowledge, this is the first large-scale study of HR-HPV prevalence and genotype distribution among women in Samsun Province of Turkey. The other types containing one or more types made up the majority of the studied population.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2477
2482
https://journal.waocp.org/article_90220_7212d31c1a10799ed70a387572f66310.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2477
Prevalence and Associated Factors of Depression Symptoms in Women Newly Diagnosed with Breast Cancer in Kazakhstan
Botagoz
Turdaliyeva
Department of Epidemiology, Evidence-Based Medicine and Biostatistics, Kazakhstan’s Medical University “KSPH,” Almaty,
Kazakhstan.
author
Indira
Karibayeva
Department of Public Health, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
author
Fatima
Bagiyarova
Department
of Communicative Skills, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
author
Nor Zuraida
Zainal
Department of Psychological
Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
author
Dinara
Kussainova
Department of Psycho-Social Help, Kazakh
Institute of Oncology and Radiology, Almaty, Kazakhstan.
author
text
article
2022
eng
Introduction: Diagnosis of breast cancer is associated with the presence of psychological disorders including depression. There is a lack of study examining the prevalence of depression among newly diagnosed breast cancer patients in Kazakhstan. Objective: This study aims to assess the prevalence and associated sociodemographic and clinical factors of depression symptoms in women newly diagnosed with breast cancer. Methods: 162 newly diagnosed breast cancer patients at the oncology center in Almaty were recruited for this study. Data were collected using a structured questionnaire on sociodemographic and clinical information and the Beck Depression Inventory-II scale. Results: The mean age of the patients was 54.41 years (SD=8.1). 95% of participants had unilateral breast cancer, and 79% of participants had stage I or stage II breast cancer. 73% of patients said that they do not have reliable social support. 46% of patients had symptoms of moderate depression, and 31% of patients had symptoms of severe depression. According to the multivariate analysis, factors associated with depression symptoms were: social status, household income level, reliability of social support, and stage of breast cancer. Conclusion: The prevalence of depression symptoms is very high among newly diagnosed breast cancer patients. Unemployed or retired patients, with a lower household income, and no reliable social support diagnosed with an advanced stage of breast cancer are especially at high risk for developing depression.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2483
2489
https://journal.waocp.org/article_90203_8a74740c8eef924efdcba942f3576f69.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2483
Immunohistochemical Expression of Programmed Death Ligand 1(PDL1) in Endometrial Carcinoma and Its Relation to CD4 and CD8 Positive Immune Cells
Maha
Salama
Pathology Department, Faculty of Medicine, Cairo University, Egypt.
author
Dina
Khairy
Pathology Department, Faculty of Medicine, Beni-Suef
University, Egypt.
author
text
article
2022
eng
Objectives: Endometrial cancer (EC) is the most common cancer of the female genital tract. Egypt showed a significant increase in incidence lately of which 25% were premenopausal. Advanced or recurrent disease are mostly unresectable and the traditional adjuvant therapy give modest results with devastating side effects. Late discoveries of immune checkpoint inhibitors have produced promising results. Programmed cell death 1 (PD1) is an immune inhibiting receptor on surface of lymphocytes, which plays critical roles in maintaining immunological self-tolerance. There are two ligands for this receptor, PDL1 and PDL2. PD-L1 is expressed on tumor cells; attaches to PD1, allowing tumor cells to escape from the host immune response. Its prognostic significance in various tumors is controversial and its significance in ECs has just begun to be investigated. Therefore, we investigated the relationship between PDL1 expression and different clinicopathologic parameters in EC cases and its correlation with CD4 and CD8 immune cells, in order to identify the predictive biomarkers for the outcome by immune therapy. Methods: Hundred, paraffin tissue blocks of EC cases were collected and stained with antibodies against PDL1,CD4 and CD8. Results: PDL1 was positive in 67% of cases in tumor cells and in 61% of cases in immune cells. CD4 and CD8 were expressed in 79% of cases. Statistically significant correlations were observed between PDL1 expression and patients mean age, LVSI, TILS score and CD4+/CD8+ expression. Conclusion: Those variables can stratify candidates who can benefit most from immunotherapy, or can be chosen for further high cost molecular investigations application.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2491
2496
https://journal.waocp.org/article_90204_3d1c46717dc2fa0e8a6cfae2b373b292.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2491
Increasing Immune Dysfunction is Associated with Increasing Matrix-Metalloproteinase-2 Expression and Predicts Biochemical Failure in Men with Bone Marrow Micro-Metastasis Positive Localized Prostate Cancer
Nigel
Murray
CTC Unit, Faculty of Medicine, University Finis Terrae, Santiago, Chile.
author
Socrates
Aedo
Faculty of Medicine, University Finis Terrae
Santiago, Chile.
author
Cynthia
Fuentealba
Urology Service, Hospital de Carabineros de Chile, Santiago, Chile.
author
Eduardo
Reyes
Faculty of Medicine, University Diego
Portales Santiago, Chile.
author
Anibal
Salazar
Department of Urology, Hospital de Carabineros de Chile, Santiago, Chile.
author
text
article
2022
eng
Introduction: To determine if there was an association of the ALC (absolute lymphocyte count) and LCP (lymphocytopenia) with the expression of MMP-2 in bone marrow micro-metastasis, the changes occurring during follow-up and association with biochemical failure. Methods and patients: One month after surgery blood and bone marrow samples were taken to determine the presence of micro-metastasis, the presence of circulating prostate cells (CPCs) and ALC. CPCs and micro-metastasis were detected using immunocytochemistry and MMP-2 expression determined in micro-metastasis. Only men positive for micro-metastasis participated in the study. At end follow blood was taken for serum PSA, ALC and CPCs, if the ALC decreased by more than 10% bone marrow sampling was repeated and MMP-2 expression determined, similarly for men with BF. Men who had stable ALCs had an end of study evaluation of the bone marrow. Results: 402 men underwent radical prostatectomy, one month post surgery 79 men were positive for only bone marrow micro-metastasis and formed the study group; of whom 36/79 (45%) underwent BF. Clinical pathological findings were not significantly different between men with or without BF. In men with BF the ALC was significantly lower one-month post surgery. The 5 and 10 year Kaplan-Meier survival was 100% at 5-years and 65% at 10-years for the whole cohort. Men without BF had stable ALCs. A decrease of >10% in the ALC was associated with increasing MMP-2 expression in the micro-metastasis and surrounding stromal tissue, the appearance of CPCs 6-12 months later and BF. Conclusions: the immune host-tumour cell interaction in the microenvironment is dynamic and changes with time. A decreasing ALC may be a valuable marker in identifying men with high risk of BF and changes in immune mediated dormancy before the PSA rises.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2497
2505
https://journal.waocp.org/article_90205_13a98d06cfbcd86d5dfbb1af72783911.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2497
Newly Substituted Anilino-Fluoroquinolones with Proliferation Inhibition Potential against a Panel of Cancer Cell Lines
Mohammed
Salih
School of Pharmacy, University of Jordan, Amman 11942, Queen Rania Street, Jordan.
author
Yusuf
Al-Hiari
School of Pharmacy, University of Jordan, Amman 11942, Queen Rania Street, Jordan.
author
Violet
Kasabri
School of Pharmacy, University of Jordan, Amman 11942, Queen Rania Street, Jordan.
author
Rula
Darwish
School of Pharmacy, University of Jordan, Amman 11942, Queen Rania Street, Jordan.
author
Hamza
Abumansour
Faculty of Pharmacy, Al-Zaytoonah
University of Jordan, P.O.Box 130 Amman 11733 Jordan.
author
Laurance
Bourghli
Faculty of Pharmacy, Al-Zaytoonah
University of Jordan, P.O.Box 130 Amman 11733 Jordan.
author
Sundus
Al Alawi
School of Pharmacy, University of Jordan, Amman 11942, Queen Rania Street, Jordan.
author
Rabab
Albashiti
School of Pharmacy, University of Jordan, Amman 11942, Queen Rania Street, Jordan.
author
text
article
2022
eng
Background: From a chemistry point of view, we hypothesized that superlative dual cytotoxicity-radical scavenging bioefficacies of series 4 FQs correlate to their acidic groups and C8-C7 ethylene diamine Chelation Bridge. Methodology: Newly synthesized 16 lipophilic-acid chelating FQs have been screened for in vitro duality of proliferation inhibition and radical scavenging capacities. Results: Substantially in LPS prompted RAW264.7 macrophages inflammation, IC50 values (µM) in the ascending order of new FQs’ NO scavenging/antiinflammation capacity were 4e<4b<3d<4f<5c0.05). In comparison to classical and robust antineoplastic agent cisplatin and unlike triazoloFQs; nitroFQs (3a, 3b and 3f) and the reduced FQs (4a, 4c, 4d and 4e) exerted antiproliferation IC50 values <50 µM in leukaemia K562. Besides nitroFQ 3, the reduced FQs (4c and 4f) exhibited antineoplastic IC50 values <50 µM in lung A549 carcinoma. NitroFQ 3c and reduced FQs 4b, 4c, and 4f in breast MCF7 and reduced 4c in pancreatic PANC1 had reduction of viability IC50 values <50 µM. NitroFQ 3e, reduced FQs 4b and, 4c and triazoloFQ 5a exerted antiproliferation IC50 values <50 µM in breast T47D cells. Also nitroFQ 3e, reduced FQ 4c and triazoloFQ 5f exhibited antineoplastic IC50 values <50 µM in PC3 prostate cancer cells. Exceptionally triazoloFQ 5a, but neither nitro- nor reduced FQs, had cytotoxicity IC50 value <50 µM in resistant melanoma A375 cells. Unequivocally 4b antineoplastic effectiveness linked with its radical scavenging and antiinflammation effects while 3d and 5c lacked matching antiproliferation potentialities to their exquisite antiinflammation capacities. Explicitly reduced 4e and 4f exerted antiinflammation-selective cytotoxicity duality in vitro. Conclusion: Collectively, this work reveals lipophilic-acidic chelator FQs as authentic agents for the repurposing approach in anticancer chemotherapy/prevention.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2507
2521
https://journal.waocp.org/article_90221_547de9236a6315074e8415708c4a2785.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2507
Dual Targeting of Anti-Apoptotic Proteins Enhances Chemosensitivity of the Acute Myeloid Leukemia Cells
Behzad
Baradaran
Immunology Research Center, Tabriz University of Medical sciences, Tabriz, Iran.
author
Roya
Nazmabadi
Department of Immunology, Faculty of
Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
author
Zohreh
Ariyan
Department of Medical Laboratory Sciences, Faculty
of Medicine, Arak University of Medical Sciences, Arak, Iran.
author
Ebrahim
Sakhinia
Department of Medical Genetics, Faculty of Medicine, Tabriz
University of Medical Sciences, Tabriz, Iran.
author
Hadi
Karami
Department of Molecular Medicine and Biotechnology, Faculty of Medicine, Arak
University of Medical Sciences, Arak, Iran.
author
text
article
2022
eng
Background: Acute myeloid leukemia (AML) is a type of blood cancer characterized by fast cellular proliferation. Myeloid cell leukemia-1 (Mcl-1) and survivin, as anti-apoptotic proteins, are involved in cancer growth and resistance to chemotherapy. The aim of this study was to examine the combination effect of Mcl-1 and survivin specific siRNAs on chemosensitivity of the human HL-60 AML cells. Methods: SiRNAs transfection was performed by using Lipofectamine™2000 reagent. The mRNA expression was analyzed by real-time quantitative PCR. The apoptosis analysis was measured by ELISA cell death assay. Results: siRNAs markedly suppressed mRNA expression levels of Mcl-1 and survivin in a time-dependent manner, resulting in reduction of leukemic cell proliferation and enhanced spontaneous cell death. Surprisingly, Mcl-1 siRNA and survivin siRNA synergistically enhanced the cell toxic effects of etoposide. Furthermore, down-regulation of Mcl-1 and survivin significantly enhanced the apoptotic effect of etoposide. Conclusions: Our investigation suggests that suppression of Mcl-1 and survivin by siRNA can effectually inhibit cell growth and overcome chemoresistance of AML cells. Therefore siRNAs may be an important adjuvant in chemotherapy for AML patients.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2523
2530
https://journal.waocp.org/article_90207_958da8de81f752bee6b8c2f8a748f742.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2523
Anticancer Properties of N,N-dibenzylasparagine as an Asparagine (Asp) analog, Using Colon Cancer Caco-2 Cell Line
El-Shimaa
Mohamed
Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, 32897
Sadat City, Egypt.
author
Khalil
Bassiouny
Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, 32897
Sadat City, Egypt.
author
Abeer
Alshambky
Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, 32897
Sadat City, Egypt.
author
Hany
Khalil
Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, 32897
Sadat City, Egypt.
author
text
article
2022
eng
Objectives: This study was conducted to investigate the potential anticancer properties of N, N-dibenzyl asparagine (NNDAsp), as an Asparagine (Asp) analog, using colon cancer Caco-2 cell and the normal NCM-460 cell line. Methods: Cell viability rate and levels of produced lactate dehydrogenase (LDH) were achieved upon treatment with NNDAsp compared to Asp treatment using MTT assay and LDH production kit. The protein expression profile of asparagine synthetase (ASNS) was achieved by using ELISA and flow cytometry assay. The levels of released inflammatory cytokines, including interleukin-1 alpha (IL-1α) and IL-1 beta (IL-β), were monitored using an ELISA assay. Results: Our findings showed significant inhibition of colon cancer cell proliferation accompanied by a high level of produced LDH in a dose-dependent of an NNDAsp treatment without detectable toxic effect in normal cells. Interestingly, NNDAsp showed competitive inhibition of ASNS protein expression, in almost 3% of stained cancer cells, compared to 18% and 35% of untreated cells and cells pre-treated with Asp, respectively. Likewise, the concentration of ASNS protein was dramatically depleted in a dose and time-dependent of NNDAsp treatment in comparison with Asp treatment indicated by ELISA assay. Furthermore, as an apoptotic indicator, the expression of P53 and Caspase 3 (Caps3) was significantly increased in Caco-2 cells treated with NNDAsp at both RNA and protein levels. In contrast, their expression was markedly depleted in Asp-treated cells. In addition, the expression of both IL-1α and IL-1 β was markedly increased in Caco-2 cells in a dose and time-dependent of NNDAsp exogenous treatment. Moreover, targeting of ASNS by the Asp analog, NNDAsp, was further confirmed by the docking analysis of inhibitors ligands and crystal structure of ASNS protein. Conclusion: These data provide evidence for the effectiveness of NNDAsp in cancer treatment via selective degradation of ASNS protein expression in colon cancer cells.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2531
2540
https://journal.waocp.org/article_90206_1b9cb33b22613263e5bebbafe81c822c.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2531
Diagnostic Performance of Circulating Tumor Cells for Predicting of Hepatocellular Carcinoma in Hepatitis C Virus-High Risk Patients: Role of Liquid Biopsy
Hatem
El-Mezayen
Chemistry Department, Helwan University, Cairo, Egypt.
author
Mohamed
El-Kassas
Endemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt.
author
Fathy
El-Taweel
Chemistry Department, Damietta University, Damietta, Egypt.
author
Fateheya
Metwally
Environmental and Occupational Medicine Department, National Research Center, Giza, Egypt.
author
Noha
Ghonaim
Chemistry Department, Damietta University, Damietta, Egypt.
author
Rasha
Zahran
Chemistry Department, Damietta University, Damietta, Egypt.
author
text
article
2022
eng
Purpose: Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and a global health problem. It is often diagnosed at advanced stage where hopeless for effective therapies. Identification of more reliable biomarkers for early detection of HCC is urgently needed. circulating tumor cells (CTCs) represent a unique liquid biopsy carrying comprehensive biological information of the primary tumor. Herein, we sought to develop a novel score based on the combination of the most significant CTCs biomarkers with and routine laboratory tests for accurate detection of HCC. Methods: Cytokeratin 18 (CK18), Cytokeratin 19 (CK19), albumin, platelets count, and α-fetoprotein were assayed in HCC patients (42), liver cirrhosis patients (83) and healthy control (20). Results: Areas under receiving operating curve (AUCs) were calculated and used for construction on novel score. A novel score named HCC-CTCs = AFP (U/L) × 0.08 - Albumin (g/dl) × 84 + CK 18 % × 2.9 + CK19 × 3.1- Platelets count (×109)/L× 0.75– 510. HCC-CTCs score produce AUC of 1 for differentiate patients with HCC from those with liver cirrhosis with sensitivity and specificity of a cut-off 0. Conclusions: HCC-CTCs score could replace AFP during screening of HCV patients and early detection of HCC.
Asian Pacific Journal of Cancer Prevention
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
1513-7368
23
v.
7
no.
2022
2541
2549
https://journal.waocp.org/article_90209_de652d9f2fb2b183c345086d2f27cabd.pdf
dx.doi.org/10.31557/APJCP.2022.23.7.2541