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8million) fluctuates with numbers oftemporary visitors, many of whom visit Bangkok temporarily for services. If these visitors are mis-categorized asusual residents, cancer incidence rateswould be inflated. During 2013-2015, residential addresses on the Registrywere cross-checked against official addresses on the National Civil Registration records of the Ministry of Interior.The effectsof this cross-checking on incidence rates are discussed. Methods: Residential addresses recorded onthe Registry for cancer diagnoses in 2013-2015 were corrected using official Ministry data. Effects on numbers ofrecorded cancers and crude and directly age-standardized rates (World Population) were determined. Results: Of 44,813cancer casesdiagnosed and recorded on the Registryduring 2013-2015, 36,327 (81.1%) had an official Bangkokaddress. When limiting analyses to these cases, the crude incidencefor all cancer sites combined reduced by 18.9%(19.7% for males and 18.3% for females). Corresponding reductions in age-standardized incidence rates were 20.0%for males and 18.8% for females. These reductions varied for common cancer sites:in males,from 14.8% for lung to25.9% for colorectal cancer; and in females, from 12.9% for lung to 24.0% for cervical cancer. Conclusions: Thesedifferences are considered sufficient in magnitude to justifyroutine use of official residential data when calculatingcancer incidence rates for Bangkok. If these rates are to be compared with comparable rates for other Asian citiesthatserve broader populations, equivalent methodologies for determining residential status would be needed for all cities.]]>
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0.2 ng/ml after having decreased to recurrence-free survival was estimated by the Kaplan-Meier method. Multivariate analysis was performed using aCox proportional hazards regression model. Results: The median age was 66 years, median initial prostate-specificantigen level was 6.9 ng/ml, and median follow-up period was 47.3 months. Biochemical recurrence was recognizedin 27 patients (16.1%) after laparoscopic radical prostatectomy, and 5-year biochemical recurrence-free survival was78.6%. Gleason pattern 5 was noted in 5 patients as the primary pattern, in 10 as the secondary pattern, and in 5 as thetertiary pattern. According to multivariate analysis, presence of Gleason pattern 5 (HR = 4.75, p=0.001) and positivesurgical margin (HR = 4.66, p=0.001) were independent predictive factors for biochemical recurrence-free survival.Conclusion: Gleason pattern 5 appears to be an important predictive factor for biochemical recurrence after laparoscopicradical prostatectomy.]]>
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G on exon 1 (6%, 95%CI=3- 9%), the intronic IVS1 +116C>T variant on intron 1 (0.6%, 95%CI= 0-2%), the non-synonymous variant on exon3; 415C>T (0.6%, 95%CI= 0-2%), A novel non-synonymous variant on exon 3; 404C>A (0.6%, 95%CI= 0-2%) , andtwo novel variants on 3’UTR ;502G>A (2%, 95%CI= 0.5-4%) and 588T>C (0.6%, 95%CI= 0-2%). NUDT15 36A>Gwasfound to be the most common allele among Jordanians was. In silico softwares predicted that the novel NUDT15404C>A was harmful and affected NUDT15 enzyme’sstability and function. Furthermore, the frequency of NUDT15IVS1 +116C>T , among Jordanians, showed to be significantly lower from what was reported in other ethnicities withap value > 0.05 on the other hand, the frequency of 415C>T variant showed to be similar to Europeans in contrast toAsians and Indians that showed to be significantly lower (p value > 0.05). Conclusions: The frequency of NUDT15genetic variants is low among the Jordanian volunteers and significantly lower than other ethnic groups. The findings ofthis study may increase our understanding of the inter-individual variation in the response to purine analog drugs. Furtherclinical studies are needed to investigate the influence of novel NUDT15 404C>A on drug metabolism and response.]]>
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50% tissue involvement by carcinoma. Conclusion: Significantassociation of AR expression was noted with total Gleason score, WHO grade and percentage of tissue involvement(tumor quantification) which are among the most important markers of tumor progression; therefore we suggest that ARexpression should be performed in patients with prostatic adenocarcinoma for prognostic stratification of the patients.]]>
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