p. 1935−1937
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p. 1939−1943
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Vol.20/No.7
p. 1945−1949
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C polymorphismwas significantly associated with lung cancer risk under four genetic models, i.e., allele (CT vs. TT: OR= 1.17, 95% CI1.01-1.35, p=0.02), homozygote (CC vs. AA: OR= 1.64, 95% CI 1.29-2.02, p≤0.001), heterozygote (CA vs. AA: OR=1.26, 95% CI 1.06-1.50, p≤0.001), and dominant (CC+CA vs. AA: OR= 1.31, 95% CI 1.11-1.54, p=0.001). However,there was no significant association between -819T>C and -1082A>G polymorphisms of IL-10 and lung cancer risk.Similarly, subgroup analyses by ethnicity detected significant association between IL-10 -592A>C and lung canceramong Asians and Caucasians. Conclusions: Our meta-analysis suggests that the IL-10 -592A>C polymorphism mightbe risk factor for lung cancer, especially among Asian and Caucasians. In contrast, the IL-10 -819T>C and -1082A>Gpolymorphisms are not significantly associated with increased risk of lung cancer.]]>
p. 1951−1957
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p. 1959−1965
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Vol.20/No.7
0.05). However, efficacy and perceived distress of theintervention group significantly was decreased following the intervention (P<0.05). Conclusions: According to thefindings regarding the impact of home care using EMDR technique on reducing stress in patients with gastrointestinalcancer, the implementation of this intervention and provision of education for patients are recommended to expand thenursing duty to community health wards as well as to improve the health status of patients.]]>
p. 1967−1971
2476-762X
Vol.20/No.7
p. 1973−1977
2476-762X
Vol.20/No.7
control). Real-time PCR showed Fas and Baxgene upregulation and Bcl-2 downregulation, which resulted in an increased Bax/Bcl-2 expression ratio. The extractsincreased lymphocyte proliferation and increased levels of IFN-γ production in the presence and absence of mitogen(p < 0.05). They significantly increased IL-4 and decreased IL-10 secretion by mitogen-stimulated lymphocytes.E. hebecarpa also increased IL-17 release. Conclusion: These results have shown that both extracts possess antitumoractivity by inducing apoptosis, possibly through both intrinsic and extrinsic pathways. In addition, they induced secretionof different T helper subset related cytokines that are effective in the immune response against cancer.]]>
p. 1979−1988
2476-762X
Vol.20/No.7
p. 1989−1994
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Vol.20/No.7
p. 1995−2001
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p. 2003−2008
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p. 2009−2013
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Vol.20/No.7
p. 2015−2020
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Vol.20/No.7
p. 2021−2025
2476-762X
Vol.20/No.7
p. 2027−2032
2476-762X
Vol.20/No.7
p. 2033−2037
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Vol.20/No.7
p. 2039−2043
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Vol.20/No.7
p. 2045−2050
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Vol.20/No.7
p. 2051−2057
2476-762X
Vol.20/No.7
p. 2059−2064
2476-762X
Vol.20/No.7
p. 2065−2072
2476-762X
Vol.20/No.7
p. 2073−2078
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Vol.20/No.7
p. 2079−2085
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Vol.20/No.7
p. 2087−2093
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p. 2095−2101
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Vol.20/No.7
p. 2103−2107
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Vol.20/No.7
p. 2109−2115
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p. 2117−2123
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Vol.20/No.7
p. 2125−2130
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p. 2131−2137
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Vol.20/No.7
p. 2139−2143
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p. 2145−2152
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Vol.20/No.7
p. 2153−2158
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Vol.20/No.7
p. 2159−2166
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Vol.20/No.7
20 times per week consists of 50-60 g during the last 2-4 years. Results: The gutkha and khaini users foundto be significantly increased levels of iNOS (Inducible nitric oxide synthase) enzyme in plasma, erythrocytes, andplatelet membranes when compared to normal controls. The gutkha and khaini users exhibited that the significantincrease in the levels of gene expression of apoptotic proteins (Bcl2-B cell lymphoma gene 2, Bax, caspases 8, caspase10, and caspase 12), IL-6 (Interleukin-6), and decreased levels of TNF-α (Tumor necrosis factor-alpha) and decreasedexpression of caspase 12 of khaini users were observed from blood samples. The significant increase in the concentrationsof peroxynitrites (ONOO-), nitric oxide (NO) (Nitrates and nitrites), malondialdehyde (MDA), cholesterol, andphospholipids were reported in the smokeless tobacco users of erythrocytes and platelets. The experimental subjectsshowed that the increased osmotic fragility and decreased membrane fluidity of erythrocytes and platelets in comparisonwith non-tobacco users. The normal subjects had been exposed that the proper functioning of antioxidant enzymes anddecreased enzyme activities of antioxidants were reported by SLT users. Conclusion: The smokeless tobacco productsare exerted chronic damage to membranes of erythrocytes and platelets and elevation of apoptosis in the prolongedperiods of human male volunteers.]]>
p. 2167−2176
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p. 2177−2180
2476-762X
Vol.20/No.7
p. 2181−2194
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Vol.20/No.7
p. 2195−2201
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Vol.20/No.7
p. 2203−2208
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p. 2209−2212
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Vol.20/No.7
p. 2213−2218
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Vol.20/No.7
p. 2219−2224
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Vol.20/No.7
p. 2225−2238
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Vol.20/No.7