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0.05). There was no statistically significant relationship among the quality of sleep of parents, education,
gender, and place of residence, but there was a statistically significant relationship between state anxiety and education
(p≤0.05). Conclusion: The results can predispose family-centered nursing care to support more the parents of children
with cancer in the face of the stress of illness. Developing programs for training muscle relaxation techniques will
improve family functioning and mental health.]]>
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G Polymorphism with Acute Myeloid Leukemia in an Iranian Population: A Case- Control Study]]>
G]]>
G
(rs2279744) polymorphism in AML remains unclear. We have performed this study to examine the association of MDM2
-309T>G with AML in an Iranian population. Methods: We have examined the association of N MDM2 -309T>G
polymorphism in 73 cases diagnosed with AML and 80 healthy controls by tetra-primer amplification refractory mutation
system (ARMS) PCR assay. Odds ratios (OR) and 95% confidence intervals (CI) were calculated on the risk genotypes
and alleles. Results: The TT, GG and GG genotypes of MDM2 -309T>G polymorphism in patients were 32.9%, 23.2%
and 43.9%, while in controls were 86.2%, 7.5% and 6.3%, respectively. Moreover, Frequency of mutant allele (G)
was 55.6% in cases with AML and 10.0% in controls. The mutant homozygote genotype (GG) was associated with an
increased susceptibility to AML (OR 1.471; 95% CI: 1.062-1.844; p=0.004). Conclusion: Our results showed that the
MDM2 -309T>G polymorphism was significantly associated with increased risk of AML in the Iranian population.
Thus, the MDM2 -309T>G polymorphism might be useful genetic susceptibility factors in the pathogenesis of AML.]]>
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1.0 RQ and there was a highly statistically significant difference between cases and controls regarding SALL4 gene expression where all cases showed higher expression of SALL4 than controls with p value SALL4 is one of few genes that bridge the self-renewal properties of ESCs, normal HSCs and LSCs. Their expression is easily determined by real time PCR. They may be useful markers to predict prognosis and help to stratify patients into risk adapted groups. Further studies including increasing patient numbers are essential to understand the relations between SALL4 gene expression and its prognostic impact.]]>
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