p. 1881−1886
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p. 1887−1892
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p. 1893−1898
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G Polymorphism and Risk of Squamous Cell Carcinomas of Head and Neck: a Meta-analysis]]>
G]]>
G polymorphism on head and neck squamous cell carcinoma (HNSCC) susceptibility. However, the results remain controversial and ambiguous. We therefore carried out a meta-analysis to explore more precisely the association between MDM2 309T>G variants and the risk of HNSCC. Methods: Studies on the association between MDM2 309T>G polymorphism and HNSCC were searched in the PubMed database. All relevant studies that met the inclusion criteria were eligible for the analysis. Four genetic models and generalized odds ratios (ORs) and 95% confidence interval (CIs) were used for the assessment. Results: A total of seven articles with 1,629 cases and 2,472 controls were included in our meta-analysis. Overall, significant associations between the MDM2 SNP309T>G and HNSCC risk for TG vs. TT model and the dominant model (TG+GG vs. TT) were observed (OR=0.82, 95%CI=0.70-0.96 and OR=0.83, 95%CI=0.71-0.96, respectively). On subgroup meta-analysis by ethnicity, a negative association was shown in the Caucasian subgroup (for GG vs. TT: OR=0.661, 95%CI=0.455-0.960; for TG vs. TT: OR=0.653, 95%CI=0.496-0.859; for the dominant model GG+TG vs. TT: OR= 0.657, 95%CI=0.463-0.931). However, in the Asian population no significant association was found. Subgroup analysis by the source of controls also yielded non-significant results. None of the results were materially altered in any genetic model after studies which did not fulfill Hardy-Weinberg equilibrium were excluded. Conclusion: The present meta-analysis suggested that the MDM2 SNP309 G allele probably acts as an important HNSCC protective factor in Caucasians, but no association exists in Asians.]]>
p. 1899−1903
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p. 1905−1907
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p. 1909−1916
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p. 1917−1924
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p. 1925−1929
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p. 1931−1936
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27kg/m2) categories according to WHO recommendation for analysis of the association with PSA level. Results: A total of 1,612 patients with a mean age of 64.6 were included. The mean PSA levels for the normal, overweight, and obese patients were 4.84, 4.54, and 3.95 ng/ml, respectively, with a significant negative correlation (Spearman’s coefficient= -0.05, p=0.03). A significant negative association between PSA and BMI among the normal, overweight, and obese groups was also demonstrated by analysis of variance (p=0.01). After adjusting for age differences, there was a significant difference between PSA level for obese patients with a BMI>27 (3.95ng/ml) and non-obese patients with a BMI<27 (4.67ng/ml) with analysis of covariance (p=0.02). Conclusion: In symptomatic male patients, a higher BMI was significantly associated with lower PSA levels. BMI should be considered in the interpretation of serum PSA levels in overweight and obese patients presenting with LUTS.]]>
p. 1937−1940
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Vol.12/No.8
C Polymorphism with Lung Cancer: Evidence from 9841 Subjects]]>
p. 1941−1945
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p. 1947−1952
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p. 1953−1956
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p. 1957−1960
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p. 1961−1964
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0.05). Spearman correlation test showed a significant positive relationship between education and awareness (p> 0.05). Regarding awareness of the screening methods, 92.8%, 50.4% and 47.2% of respondents correctly answered questions on capability of BSE, CBE and mammography, respectively. In conclusion, the study showed awareness of breast cancer and practice of screening procedures increases with higher education and urban living. Therefore, there is an urgent need for an intensive breast cancer awareness campaign and availablity of screening centres prioritized in rural areas.]]>
p. 1965−1967
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0.05). As a conclusion, this study showed diet may make changes to the breast density as a risk factor for breast cancer.]]>
p. 1969−1972
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p. 1973−1977
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p. 1979−1983
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p. 1985−1988
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p. 1989−1993
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p. 1995−1999
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p. 2001−2006
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p. 2007−2011
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p. 2013−2017
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p. 2019−2023
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p. 2025−2030
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p. 2031−2037
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p. 2039−2043
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p. 2045−2049
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p. 2051−2053
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p. 2055−2058
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p. 2059−2064
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p. 2065−2068
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p. 2069−2073
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p. 2075−2080
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p. 2081−2085
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Vol.12/No.8
6 months) is associated with decreased risk of the disease. Objective: To investigate the relationship between duration of breastfeeding and risk of childhood leukemia in Oman. Materials and Methods: In a case control study all recently diagnosed and registered cases of childhood leukemia at the National Registry during (1999- 2009), a total of 70 cases, were recruited. For each case, a gender and age matched control was selected either from the family relatives or from the neighbors of family siblings. Results: Breastfeeding is culturally favored for longer periods of time (up to 24 months) in Oman. Data of this study revealed that 21% of cases and 12 % of their gender and age matched controls were breastfed for an average duration of 6-12 months. In 75% of the cases and 81% of controls the period of breastfeeding was between 12-24 months. Only 4% of the cases and 7% of controls were breastfed for a period more than 24 months. No significant (P < 0.05) differences were observed between the cases and controls with respect to breastfeeding and the risk of childhood leukemia. Similarly the duration of breast feeding did not have any significant (P > 0.05) effect on the risk of childhood leukemia in Oman. Conclusion: This study indicated that duration of breastfeeding was not associated with risk of childhood leukemia in Oman and there may be some other environmental and genetic factors that might be responsible for the occurrence of this disease and must be explored further]]>
p. 2087−2091
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p. 2093−2096
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0.05). In the invasion assay, the number of transmembrane cells was significantly reduced in the ASODN group after 48 hours (58.6±9.2 P<0.01), but there was no variation amongcontrol, LIP and SOND groups (132.5±15.6, 129.7±16.1, 118.2±12.5, P>0.05). Conclusions: VEGF-C ASODN can downregulate the expression of VEGF-C in cell lines and can obviously inhibit invasive ability in vitro.]]>
p. 2097−2099
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p. 2101−2104
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p. 2105−2110
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p. 2111−2115
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0.05). Furthermore, under the analysis of haplotype, GGCTCGT and AGCTCGT were related to reduced HCC risk (OR=0.41, 95%CI=0.24, 0.70, P<0.05 and OR=0.43, 95% CI=0.22, 0.983, P<0.05, respectively), while AATTTCG was associated with an increased risk (OR= 1.64, 95% CI=1.24-2.17, P<0.05). 10-million permutation testing also indicated the AATTTCG and GGCTCGT haplotypes to be associated with HCC susceptibility (both P-values <0.05). Patients carrying AATTTCG were in higher tumor and clinical stages (P<0.05), while GGCTCGT appeared protective in this context (P <0.05). Conclusion: This study provides first evidence that FAT10 gene genetic variants may be involved in the susceptibility and clinicopathological development of HCC in the Chinese han population.]]>
p. 2117−2122
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p. 2123−2128
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p. 2129−2132
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p. 2133−2138
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p. 2139−2143
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p. 2145−2146
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p. 2147−2148
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