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5.00copies/cell (p=0.028). The group with a lower viral load also tended to have a higher rate of disease progression(75% versus 31%, p=0.080). No significant difference in the other clinicopathologic variables between the lowerand higher viral load groups was identified. Conclusion: HPV18 DNA viral load may have a prognostic valuein patients with early-stage NECA of the cervix. A low viral load may be predictive of shortened disease-freesurvival in these patients.]]>
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T Gene Polymorphism and Cancer Susceptibility - Results of a Meta-analysis]]>
T gene polymorphism]]>
T gene polymorphism and cancer risk are conflicting. This meta-analysis was performed to evaluatethe relationship with cancer susceptibility overall, and to explore whether the T allele or TT genotype couldbecome a predictive marker for cancer risk. Methods: Association studies were identified from the databasesof PubMed, Embase, and Cochrane Library as of March 1, 2012, and eligible investigations were synthesizedusing the meta-analysis method. Results were expressed with odds ratios (OR) for dichotomous data, and 95%confidence intervals (CI) were also calculated. Results: Six investigations were identified for the analysis ofassociation between the prohibitin 3’ untranslated region C > T gene polymorphism and cancer risk, covering of1,461 patients with cancer and 1,197 controls. There was a positive association between the T allele and cancersusceptibility (OR=1.20, 95% CI: 1.03-1.39, P=0.02), and CC homozygous might play a protective role (OR=0.80,95% CI: 0.68-6.11, P=0.95). In the sub-group analysis, prohibitin 3’ untranslated region C > T gene polymorphismand cancer risk appeared associated with the risk of breast cancer, but not ovarian cancer. Conclusions: Ourresults indicate that T allele is a significant genetic molecular marker to predict cancer susceptibility and CCgenotype is protective, especially for breast cancer. However, more investigations are required to further clarifythe association of the prohibitin 3’ untranslated region C > T gene polymorphism with cancer susceptibility.]]>
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0.05),including but not limited to hair dyes, alcohol drinking, smoking, and home/workplace renovation within oneyear. Conclusions: Consistent with results from previous studies in other DLBCL case populations, traditionalChinese medicine appeared to have a direct or indirect protective effect against DLBCL. However, this studyalso identified a possible predisposition for DLBCL in TB sufferers and farmers.]]>
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40 was significantly associated with laryngeal location (P<0.001). History of smoking and drinking wassignificantly associated with age >40 and SCC of larynx in both age groups. Cervical lymph node involvementwas significantly correlated with SCC of tongue (P<0.001), however, considering young adults only, SCC ofhypopharynx was most frequently accompanied by lymph node involvement (60%). The most prevalent tumoramong men was SCC of larynx whereas SCC of hypopharynx was the most prevalent tumor among women(61%), of whom 18.2% were ≤40. Conclusions: The incidence of HNSCC among young adults seems to be higherin Iran compared to other countries. Reduction in exposure to known risk factors, especially tobacco smokingin forms of cigarettes and bubble pipes, and search for other causative agents of HNSCC in young populationis recommended.]]>
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C, rs1805389 C>T, rs1805388C>T and rs2232641 A>G) and breast cancer risk, suggesting that the mutant situation of these SNPs neitherincreased nor decreased the risk for breast cancer. In the subgroup analysis by Hardy-Weinberg equilibrium(HWE) and ethnicity, we also found no associations between the variants of LIG4 gene and breast cancer riskamong HWE, non-HWE, Caucasians, Asians and Africans. Conclusion: This meta-analysis suggests that thereis a lack of any association between LIG4 gene polymorphisms and the risk of breast cancer.]]>
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T) and rs6869366 (G>T) in the XRCC4 gene were associated with increasedrisk of breast cancer, while rs2075685 (G>T) and rs10057194 (A>G) might decrease the risk of breast cancer.However, rs1805377 (A>G), rs1056503 (G>T), rs28360317 (ins>del) and rs3734091 (A>G) polymorphisms ofXRCC4 gene did not appear to have an influence on breast cancer susceptibility. Conclusion: Results from thecurrent meta-analysis suggest that the rs2075685 (G>T) and rs6869366 (G>T) polymorphisms of the XRCC4 genemight increase the risk of breast cancer, whereas rs2075685 (G>T) and rs10057194 (A>G) might be protectivefactors.]]>
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0.05). There was higher Bmi-1 protein expression in intestinal- type carcinomas than diffuse-type ones (p<0.001). At mRNA level, Bmi-1 protein expression was increased from gastritis, IM, dysplasia and carcinoma (p<0.001). Bmi-1 overexpression was observed in gastric carcinoma with larger diameter, deeper invasion, lymph node metastasis, and intestinal-type carcinoma (p<0.05). Conclusion: These findings indicate that up-regulated Bmi-1 expression is positively linked to pathogenesis, growth, invasion, metastasis and differentiation of gastric carcinomas. It was considered as a promising marker to indicate the aggressive behaviors and prognosis of gastric carcinomas.]]>
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T and GGH -401C>T was performed usinga polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP). The GGH-401CT andTT genotypes were associated with increased risk of leukopenia and thrombocytopenia after high dose MTX(OR 2.97, 95%CI; 1.24-7.13 and OR 4.02, 95%CI; 1.58-10.26). DHFR 829C>T was not associated with toxicity.In conclusion, the GGH -401CT and TT genotypes were found to increase the risk of severe leukopenia andthrombocytopenia after exposure to high dose MTX for childhood ALL therapy.]]>
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0.05) between TPE and MPE. The concentration ofIL-21 in MPE was significantly higher compared to TPE (P<0.01). With a threshold value of 4.32 pg/ml, IL-21had a sensitivity of 76.9% (40/52) and a specificity of 80.4% (41/51). Combined detection of IL-21 and CEAhad a sensitivity of 69.2% (36/52) and a specificity of 92.2% (47/51). These two markers can contribute to thedifferential diagnosis of MPEs.]]>
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