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0.05), but for RFS/CSS was 1.28 (95% CI: 1.05-1.55, P = 0.015), with statistical significance; thepooled HRs for OS and RFS/CSS in digestive system neoplasms were 3.04 (95% CI: 1.48-6.24, P =0.003) and2.61 (95% CI: 1.98-3.42, P<0.05), respectively. Conclusions: The results indicated that the miR-155 expressionlevel plays a prognostic role in patients with cancer, especially NSCLCs and digestive system carcinomas.]]>
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T) was found to be 39%. Our results suggest that frequency of XRCC3 (C>T)DNA repair gene exhibits distinctive patterns compared with the Saudi Arabian population and this mightbe attributed to ethnic variation. The present findings may help in high-risk screening of humans exposed toenvironmental carcinogens and cancer predisposition in different ethnic groups.]]>
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800 ng/ml (HR 2.538, 95% CI 1.464-4.401, P=0.001), multiple tumors (HR 2.286, 95%CI 1.123-4.246, P=0.009) and microvascular invasion (HR 2.518, 95% CI 1.475-4.298, P=0.001) to be associatedwith early recurrence (recurrence-free time ≤ 1-year) of HCC meeting Milan criteria. Conclusions: AFP > 800ng/ml, multiple tumors and microvascular invasion are independent risk factors affecting early postoperativerecurrence of HCC. In addition resection appears capable of replacing liver transplantation in some situationswith safety and a better outcome.]]>
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2 gas and the specular body, and excise the lymph nodes by ultrasonic scalpel. The surgicalfield chamber was set with negative pressure drainage and was pressured with a soft saline bag after surgery.Results: A lacuna emerged from subcutaneous of the inguinal region after lipolysis and liposuction, with a widefascia easily exposed at the bottom where lymph nodes could be readily excised. The number of lymph nodesof ten patients excised within the inguinal region on each side was 4-18. The excised average number of lymphnodes was 11 when we had mature technology. Conclusion: Most of adipose tissue was removed after lipolysisand liposuction of subcutaneous tissue of inguinal region, so that the included lymph nodes were exposed andeasy to excise by endoscope. This surgery avoided the large incision of regular surgery of inguinal region, theresults indicating that this approach is feasible and safe for used as an alternative technology.]]>
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1.36, 95%CI: 1.20~1.52, P < 0.001; dominant model:OR>1.64, 95%CI: 1.42~1.91, P < 0.001; respectively). Subgroup analyses by ethnicity indicated PALB2 geneticvariants were associated with an increased risk of breast cancer among both Caucasian and Asian populations(all P < 0.05). No publication bias was detected in this meta-analysis (all P > 0.05). Conclusion: The currentmeta-analysis indicates that PALB2 genetic variants may increase the risk of breast cancer. Thus, detection ofPALB2 genetic variants may be a promising biomarker approach.]]>
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A and four also concernedthe TNF-α-238G>A polymorphism. It was found that oral cancer risk were significant decreased with theTNF-α-308G>A polymorphism in the additive genetic model (GG vs. AA, OR=0.19, 95% CI: [0.04, 1.00],P=0.05, I2=68.9%) and the dominant genetic model (GG+GA vs. AA, OR=0.22, 95% CI: [0.06, 0.82], P=0.03,I2=52.4%); however, no significant association was observed in allele contrast (G vs. A, OR=0.70, 95% CI: [0.23,2.16], P=0.54, I2=95.9%) and recessive genetic models (GG vs. GA+AA, OR=0.72, 95% CI: [0.33, 1.57], P=0.41,I2=93.1%). For the TNF-α-238G>A polymorphism, significant associations with oral cancer risk were found inthe allele contrast (G vs. A, OR=2.75, 95% CI: [1.25, 6.04], P=0.01, I2=0.0%) and recessive genetic models (GGvs. GA+AA, OR=2.23, 95%CI: [1.18, 4.23], P=0.01, I2=0.0%). Conclusively, this meta-analysis indicates thatTNF-α polymorphisms may contribute to the risk of oral cancer. Allele G and the GG+GA genotype of TNF-α-308G>A may decrease the risk of oral cancer, while allele G and the GG genotype of TNF-α-238G>A may causean increase.]]>
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6.10 μU/ml. The highest insulin levels (>6.10μU/ml) were seen to be associated with an 2.36 fold risk of HCC when compared with fasting insulin levels of(<2.75 μU/ml). Furthermore, the insulin levels (2.75-4.10 μU/ml) of category cutpoints also conferred a 1.57fold risk for HCC when compared with lowest fasting insulin levels of (<2.75 μU/ml). Conclusions: The effectof an insulin level in increasing HCC risk appeared consistent, influencing incidence, risk of recurrence, overallsurvival, and treatment-related complications in HCC patients.]]>
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0.05). Conclusions: Renal cancer is more aggressive in patients with metabolicsyndrome. Lifestyle and risk factors were revealed to be significant influences in renal cancer patients.]]>
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10 times). Results: The 3-month and 5-year complete response (CR) rates of cervical lymph nodesin the hyperthermia group were significantly higher than those in the control group. The 5-year disease-freesurvival (DFS) rate and the 3-year / 5-year overall survival rate in the hyperthermia group were also significantlyhigher. There was no significant difference in 5-year metastatic rates. In the hyperthermia group, the 3-monthand 5-year CR rates of T90 < 43°C treatment were significantly lower than with T90 ≥ 43°C treatment. TheCR rate was highest when the hyperthermia was performed 4-10 times. There were no significant differencesin 3-month and 5-year CR rates between hyperthermia before or after radiotherapy treatment. Conclusion:Microwave hyperthermia combined with chemoradiotherapy can increase local control, DFS and 3, 5-yearoverall survival rates of patients with N2 ~ N3 stage NPC. The heating temperature should be over 43°C withhyperthermia repeated 4-10 times.]]>
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3 months) in 42% of patients. Considering the symptoms as “harmless” (39%)was the most frequent reason of delay followed by “temporary” (20%) and the “use of traditional methods”(12%). Most common reason for later approaches was an increase in the size of the lump (41%). Statisticallysignificant association (p-value <0.05) of longer patient delay was obtained with being single, being illiterate,painless breast lump as the first symptom, negative family history of breast cancer and vague attribution of thesymptoms. Conclusions: Significant delay in approach to health care facility was observed in our study due tovariable reasons given by women. Sufficient awareness regarding breast cancer, its symptoms and favorableeffects of a timely diagnosis on prognosis must be imparted to our general population.]]>
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2 were screened out by microarrayanalysis. Among them, 5 (miR-221, miR-222, miR-122, miR-19a, miR-144) were chosen for further validationin an independent population (N=72). Our results indicated serum miR-19a to be significantly up-regulated inresistance-phase serum (p=0.009). The ROC curve analysis showed that the sensitivity of serum miR-19a todiscriminate the resistant patients from the response ones was 66.7%, and the specificity was 63.9% when theAUC was 0.679. We additionally observed serum miR-19a had a complementary value for cancer embryonicantigen (CEA). Stratified analysis further revealed that serum miR-19a predicted both intrinsic and acquireddrug resistance. Conclusions: Our findings confirmed aberrant expression of serum miR-19a in FOLFOXchemotherapy resistance patients, suggesting serum miR-19a could be a potential molecular biomarker forpredicting and monitoring resistance to first-line FOLFOX chemotherapy regimens in advanced colorectalcancer patients.]]>
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85% of world new cases and deaths occur, suggesting a failureto establish comprehensive cervical-cancer control programs. Effective interventions are available to controlcervical cancer but are not all affordable in low-income settings. Disease awareness saves lives by risk-reductionas witnessed in reducing mortality of HIV/AIDS and smoking-related cancers. Subjects and Methods: We initiateda community-based awareness program on cervical cancer in two low-income Muslim Uyghur townships inKashi (Kashgar) Prefecture, Xinjiang, China in 2008. The education involved more than 5,000 women fromtwo rural townships and awareness was then evaluated in 2010 and 2011, respectively, using a questionnairewith 10 basic knowledge questions on cervical cancer. Demographic information was also collected and includedin an EpiData database. A 10-point scoring system was used to score the awareness. Results: The effectivenessand feasibility of the program were evaluated among 4,475 women aged 19-70 years, of whom >92% lived on/below US$1.00/day. Women without prior education showed a poor average awareness rate of 6.4% (164/2,559).A onetime education intervention, however, sharply raised the awareness rate by 4-fold to 25.5% (493/1,916).Importantly, low income and illiteracy were two reliable factors affecting awareness before or after educationintervention. Conclusions: Education intervention can significantly raise the awareness of cervical cancer inlow-income women. Economic development and compulsory education are two important solutions in raisinggeneral disease awareness. We propose that implementing community-based awareness programs against cervicalcancer is realistic, locally affordable and sustainable in low-income countries, which may save many lives overtime and, importantly, will facilitate the integration of comprehensive programs when feasible. In this context,adopting this strategy may provide one good example of how to achieve “good health at low cost”.]]>
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A Polymorphism Contributes to Nasopharyngeal Carcinoma Risk: Evidence from a Meta-analysis Including 1,886 Subjects]]>
A gene polymorphism may be related to nasopharyngeal carcinoma(NPC) risk but the results of individual studies remain conflicting. A meta-analysis including 1,886 subjectsfrom five individual studies was therefore performed to provide a more accurate estimation. Pooled odds ratios(ORs) and their corresponding 95% confidence intervals (95% CIs) were evaluated by fixed- or random-effectsmodels. A significant relationship between interleukin-18 promoter -607C>A gene polymorphism and NPC wasfound in a dominant genetic model (OR: 1.351, 95% CI: 1.089-1.676, P=0.006, Pheterogeneity=0.904), a homozygotemodel (OR: 1.338, 95% CI: 1.023-1.751, P=0.034, Pheterogeneity=0.863), and a heterozygote model (OR: 1.357, 95%CI: 1.080-1.704, P=0.009, Pheterogeneity=0.824). No significant association was detected in either an allelic geneticmodel (OR: 1.077, 95% CI: 0.960-1.207, 0.207, Pheterogeneity=0.844) or a recessive genetic model (OR: 1.093, 95% CI:0.878-1.361, P=0.425, Pheterogeneity=0.707). In conclusion, a significant association was found between interleukin-18promoter -607C>A gene polymorphism and NPC risk. Individuals with the C allele of interleukin-18 promoter-607C>A gene polymorphism have a higher risk of NPC development.]]>
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del polymorphism and colorectal cancer (CC) as well as age at onset in a Turkish clinical sample.Materials and Methods: A total of 122 subjects were enrolled in this case-control study (70 CC cases and 52controls). The SOCS-1 -1478CA>del polymorphism was genotyped using a polymerase chain reaction-restrictionfragment length polymorphism (PCR-RFLP) method. Results: The odds ratio of the del allele for CC relativeto the CA allele was not significantly different between the groups (OR=0.71, 95% CI=0.41–1.22, p=0.27). Thisresult did not change after adjustment for age and sex on multivariable regression analysis (OR=0.84, 95%CI=0.59–1.34, p=0.53). When the SOCS-1 -1478CA>del polymorphism was analyzed among CC patients inrelation to the age at disease onset, we found no significant differences between subjects with the del/del, CA/del,and CA/CA genotypes. Conclusions: The results of our study did not point towards a major role of the SOCS-1-1478CA>del polymorphism in the pathogenesis of CC in Turkish subjects.]]>
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0.05). Conclusions: Testing for SPAG9 may be useful for early detectionof EC in asymptomatic high-risk women. Its role in post-treatment follow-up and early detection of recurrenceshould be assessed in future trials.]]>
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