@article { author = {Usuda, Katsuo and Matoba, Takuma and Usuda, Katsuo and Sagawa, Motoyasu and Maeda, Sumiko and Motono, Nozomu and Tanaka, Makoto and Machida, Yuichiro and Munetaka Matoba, Takuma and Watanabe, Naoto and Tonami, Hisao and Ueda, Yoshimichi and Uramoto, Hidetaka}, title = {Diagnostic Performance of Whole-Body Diffusion-Weighted Imaging Compared to PET-CT Plus Brain MRI in Staging Clinically Resectable Lung Cancer}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {17}, number = {6}, pages = {2775-2780}, year = {2016}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {APJCP.2016.17.6.2775}, abstract = {Background: Precise staging of lung cancer is usually evaluated by PET-CT and brain MRI. Recently, however, whole-body diffusion-weighted magnetic resonance imaging (WB-DWI) has be applied. The aim of this study is to determine whether the diagnostic performance of lung cancer staging by WB-DWI is superior to that of PET-CT+brain MRI. Materials and Methods: PET-CT + brain MRI and WB-DWI were used for lung cancer staging before surgery with 59 adenocarcinomas, 16 squamous cell carcinomas and 6 other carcinomas. Results: PET-CT + brain MRI correctly identified the pathologic N staging in 67 patients (82.7%), with overstaging in 5 (6.2%) and understaging in 9 (11.1%), giving a staging accuracy of 0.827. WB-DWI correctly identified the pathologic N staging in 72 patients (88.9%), with overstaging in 1 (1.2%) and understaging in 8 patients (9.9%), giving a staging accuracy of 0.889. There were no significant differences in accuracies. PET-CT + brain MRI correctly identified the pathologic stages in 56 patients (69.1%), with overstaging in 7 (8.6%) and understaging in 18 (22.2%), giving a staging accuracy of 0.691. WB-DWI correctly identified the pathologic stages in 61 patients (75.3%), with overstaging in 4 (4.9%) and understagings in16(19.7%), giving a staging accuracy of 0.753. There were no significant difference in accuracies. Conclusions: Diagnostic efficacy of WB-DWI for lung cancer staging is equivalent to that of PET-CT + brain MRI.}, keywords = {Lung cancer,staging,whole body diffusion,weighted magnetic resonance imaging,MRI,PET-CT}, url = {https://journal.waocp.org/article_16311.html}, eprint = {https://journal.waocp.org/article_16311_0377e1b8a0132e1a5d7d8324a016f8a2.pdf} }