@article { author = {}, title = {Evaluation of Apoptosis-Induction by Newly Synthesized Phthalazine Derivatives in Breast Cancer Cell Lines}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {7}, number = {2}, pages = {249-252}, year = {2006}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Newly synthesized phthalazine derivatives including copper and platinum complexes were evaluated forcytotoxicity in human breast cancer cell lines. The cells were incubated with the compounds (100 μM) for 72 h andcytotoxicity, apoptosis and DNA content were measured by flow cytometery. Our results suggest that the parent (H1-2), copper (C1-2)- and platinum (P1-2)-derivatized compounds were relatively more active in inducing apoptosisand cell killing in both human breast cancer cell lines, MDA-MB-231 cells being the more sensitive. Other compoundsshowed weak or no response towards these parameters except H-5 causing 40% apoptosis in MDA-MB-231 cells.Addition of copper or platinum in the structures generally reduced the apoptotic potential. Possible roles for structure activity relationships are discussed.}, keywords = {Phthalazine,platinum compounds,human breast carcinoma cells,MCF-7,MDA-MB-231}, url = {https://journal.waocp.org/article_24462.html}, eprint = {https://journal.waocp.org/article_24462_0f611ed4e6b7c50d116d393e71cc1fae.pdf} }