@article { author = {}, title = {Expression of ER, PR, and Her-2/neu in Endometrial Cancer: A Clinicopathological Study}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {11}, number = {1}, pages = {215-220}, year = {2010}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Objective: To determine any association between expression of estrogen receptor (ER), progesterone receptor(PR), and Her-2/neu and clinicopathological features, including survival, of endometrial carcinoma (EMC)patients. Methods: Samples of formalin-fixed, paraffin-embedded tissue of 108 patients with EMC treated atour institution between January 1994 and December 2007 were immunohistochemically studied. Results: ER,PR, and Her-2/neu expression were positive in 59.3%, 65.7% and 2.8% of cases, respectively. Positive ERexpression was significantly associated with grade I-II tumor while PR expression was linked with endometrioidhistology, grade I-II tumor, less myometrial invasion (MI) and negative lymph node involvement. Her-2/neuexpression was significantly associated with deep MI, while positive ER and negative Her-2/neu expression incombination was significantly associated with longer disease-free and overall survival. Conclusion: ER expressionis a good prognostic factor while Her-2/neu expression appears to be a poor indicator for both disease-free andoverall survival, while PR tended to show favorable influence for only disease-free survival of Thai EMCs.}, keywords = {endometrial carcinoma,ER and PR expression,Her-2/neu status}, url = {https://journal.waocp.org/article_25147.html}, eprint = {https://journal.waocp.org/article_25147_3e5c94cdb2fe12ce323c1fff92db1dd1.pdf} }