@article { author = {}, title = {Caveolin-1 Promotes Mammary Tumorigenesis: MutationalProfile of the Kashmiri Population}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {11}, number = {3}, pages = {689-696}, year = {2010}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Backgroung: The role of caveolae and the caveolin proteins in cancer has been the subject of extensiveresearch. It has been suggested that caveolin-1 (Cav-1) may contribute to certain steps of carcinogenesis. In thepresent study we focused on its potential clinical relevance in mammary malignancies. Methods: We investigated130 breast cancer samples along with adjacent normal tissues using allele specific PCR for the mutation statusand then conventional PCR-SSCP and sequencing of mutated samples along with the normal adjacent tissues.Results: Caveolin-1 was identified in a screen for genes involved in breast cancer progression and we demonstrated29.2% mutational status in our Kashmiri ethnic population. We were able to detect 38 mutations out of which22 were missense, 4 were nonsense, and 12 were frame shifts amongst these 38 we were also able to detect tennovel Cav-1 mutations (missense and frameshift mutations). Conclusion: We conclude that our study suggeststhat the gene encoding Cav-1 plays an important role in the promotion of mammary tumorigenesis and areassociated with the development and progression of breast cancer.}, keywords = {breast cancer,Cav-1,Mutation,As-PCR,PCR-SSCP}, url = {https://journal.waocp.org/article_25265.html}, eprint = {https://journal.waocp.org/article_25265_bc191b06a8c28aa56bb0fecc45a1c602.pdf} }