@article { author = {}, title = {Flow Cytometry Results at Diagnosis and Relapse in Childhood Acute Lymphoblastic Leukemia}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {11}, number = {5}, pages = {1321-1324}, year = {2010}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Introduction: Several studies have focused on the immunophenotype of the leukemic population at the timeof relapse compared to that observed at diagnosis. Objectivew: The question of whether differences exist betweensurface antigens levels on blasts at the time of diagnosis and at relapse in cases of acute lymphoblastic leukemia(ALL) was addressed. Materials and Methods: A total of 25 All patients were included. Flow cytometry andfluorescein-isothiocynate conjugated antibodies were used to determined surface antigens levels. Results: Themost frequently detected five antigens were I2 (n=21), CD10 (n=17), CD41 (n=16), CD2 (n=14) and CD7/CD19(n=13/n=13) at the time of diagnosis and CD41 (n=21), I2 (n=20), CD10 (n=14), CD19 (n=16) and CD2 (n=12)at the time of relapse. There was a significant difference only between CD41 levels at the time of diagnosis andat the time of relapse (p=0.041). Conclusion: We found changes in antigen expressions at the time of relapse inALL patients. This condition ought to be evaluated with reference to prognosis of leukemia.}, keywords = {Acute Lymphoblastic Leukemia,Leukemia,childhood}, url = {https://journal.waocp.org/article_25371.html}, eprint = {https://journal.waocp.org/article_25371_733a5c7b9711cb19a385e787cea192be.pdf} }