@article { author = {}, title = {Influence of MDR1 Gene Codon 3435 Polymorphisms on Outcome of Platinum-based Chemotherapy for Advanced Non Small Cell Lung Cancer}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {12}, number = {9}, pages = {2291-2294}, year = {2011}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Objective: To evaluate the influence of multi-drug resistance 1 (MDR1) gene codon 3435 polymorphisms on response to platinum-based chemotherapeutic regimens for advanced non small cell lung cancer (NSCLC). Methods: Responses and overall survival were evaluated in a series of patients presenting between March 1, 2005 and December 31, 2010. MDR1 gene C3435T polymorphisms were genotyped using peripheral blood with real time polymerase chain reaction (RT-PCR) and relationships between the MDR1 C3435T genetic polymorphismand response rate of chemotherapy were analyzed by SPSS 13.0. Results: Overall response to chemotherapy in the eligible 103 patients was 21.4%. Patients with C/C genotype in MDR1 codon 3435 had a significantly higher response rate (24.5%) than those for C/T(19.0%) and T/T(12.5%) (P<0.05). The overall median survival time (MST) of patients was 19 months, values with C/C, C/T and T/T genotype were 21, 15.5 and 17 months, respectively (P=0.487). Conclusion: Our research suggested that patents with the C/C genotype in MDR1 codon 3435 could be more sensitive to platinum-based chemotherapy than patients with C/T and T/T; however, no significant difference was found between overall survival and MDR1 codon 3435 genetic polymorphisms.}, keywords = {Multi-drug resistance,platinum,Non Small Cell Lung Cancer,Chemotherapy,genetic polymorphisms}, url = {https://journal.waocp.org/article_25876.html}, eprint = {https://journal.waocp.org/article_25876_f579653fb604bc394a938a7f19d970a3.pdf} }