@article { author = {}, title = {HLA-B*07 is a High Risk Allele for Familial Cervical Cancer}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {12}, number = {10}, pages = {2597-2600}, year = {2011}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Aim: The purpose of this study was to investigate 50 women from eight families with familial cervical cancer in Wufeng County, Hubei Province, China, a region with a high incidence of cervical cancer. Eighty-nine healthy women, of similar age, location and ethnicity, were selected as a control group. Methods: Blood samples were collected from both groups, and HLA-A, HLA-B, and HLA-DRB1 genotypes were profiled with the Multi-Analyte Profiling system (xMAP) (Luminex HLA-SSO) using a WAKFlow HLA typing kit. Results were analyzed with Luminex HLA typing software and showed good stability, reproducibility and specificity. Results: We found several high risk alleles in women with familial cervical cancer, that associated with the highest risk being HLA-B*07 (OR = 8.7, 95% CI = 1.8-41.1). Conclusions: HLA-B*07 is a high risk allele for cervical cancer, and has strong potential for use as a molecular biomarker.}, keywords = {cervical cancer,familial risk,Allele,Haplotype,HLA}, url = {https://journal.waocp.org/article_25929.html}, eprint = {https://journal.waocp.org/article_25929_744b74b22dfa8f8ffb23c9d3bfce9c90.pdf} }