@article { author = {}, title = {The Antitumor Activity of Exogenous and Endogenous Canstatin on Colorectal Cancer Cells}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {12}, number = {10}, pages = {2713-2716}, year = {2011}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Colorectal cancer is the third most common malignancy and the third-leading cause of cancer-related deaths worldwide. In the last several years, recombinant DNA technology has made cancer gene therapy feasible in the clinic. In our studies, we used both exogenous and endogenous canstatin, a type IV collagen genetically distinct product. We detected the effects of canstatin on colorectal cancer cells HCT-15 and HCT-116. DAPI staining, FCM and migration analyse were used to detect the apoptotic cells, cell cycle and mobility. As shown in the results, the apoptotic cell numbers (p<0.05) and G1 arrest cell numbers (p<0.05) were higher than in the non-treatment case. The mobility of the cells was also decreased obviously (p<0.05). Simultaneously, combination effects of exogenous and endogenous canstatin were identified.}, keywords = {colorectal cancer,canstatin,Apoptosis,Cell cycle,Mobility}, url = {https://journal.waocp.org/article_25967.html}, eprint = {https://journal.waocp.org/article_25967_729a4ef006c35affb7c736288b3a8958.pdf} }