@article { author = {}, title = {Overexpression of Triosephosphate Isomerase Inhibits Proliferation of Chicken Embryonal Fibroblast Cells}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {12}, number = {12}, pages = {3479-3482}, year = {2011}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Triosephosphate isomerase (TPI), a glycolytic enzyme, functions in catalyzing the interconversion of glyceraldehyde-3-phosphate and dihydroxyacetone phosphate and is generally upregulated in tumours. However, there are data suggesting loss in lymphomas. To determine its effects in chicken embryonal fibroblasts (CEF) a plasmid was constructed to allow transfection. Upon culture in a suitable medium, cells transfected with the TPI demonstrated upregulation and were significantly more susceptible to apoptosis compared to controls with decreased proliferation. These finding therefore render a novel mechanism by which CEF can be triggered to undergo death by upregulation of TPI.}, keywords = {TPI,Overexpression,CEF cells,Proliferation}, url = {https://journal.waocp.org/article_26083.html}, eprint = {https://journal.waocp.org/article_26083_1fe6b7fdc740b2b631139ff58c69050c.pdf} }