@article { author = {}, title = {Galectin-9 Acts as a Prognostic Factor with Antimetastatic Potential in Hepatocellular Carcinoma}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {13}, number = {6}, pages = {2503-2509}, year = {2012}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Considerable research has been conducted concerning galectin-9 and carcinomas, but little information isavailable about any relation with the hepatocellular carcinoma. In this study, we employed a small interferingRNA (siRNA) targeting galectin-9 to down-regulate the expression in HepG2 cells. As a result, after galectin-9expression was reduced, cell aggregation was suppressed, while other behaviour such as the proliferation,adhesion and invasion to ECM, cell-endothelial adhesion and transendothelial invasion of the cells were markedlyenhanced. When tumors of 200 patients with hepatocellular carcinoma were tested for galectin-9 expression byimmunohistochemistry, binding levels demonstrated intimate correlations with the histopathologic grade, lymphnode metastasis, vascular invasion and intrahepatic metastasis (P<0.05). Moreover, survival analysis indicatedthat patients with galectin-9 expression had much longer survival time than those with negative lesions, and theLog-rank test indicated that this difference was statistical significant (P<0.0001). The Cox proportional hazardsmodel suggested that negative galectin-9 expression in hepatocellular carcinoma represented a significant riskfactor for patient survival. We propose that galectin-9 might be a new prognostic factor with antimetastaticpotential in patients with hepatocellular carcinoma.}, keywords = {Galectin-9,Hepatocellular carcinoma,Metastasis,Prognosis}, url = {https://journal.waocp.org/article_26531.html}, eprint = {https://journal.waocp.org/article_26531_6791dd23c5f14c0af3477bcf4b6af981.pdf} }