@article { author = {}, title = {Association Between Insulin-like Growth Factor-2 Expressionand Prognosis after Transcatheter Arterial Chemoembolization and Octreotide in Patients with Hepatocellar Carcinoma}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {13}, number = {7}, pages = {3191-3194}, year = {2012}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Objective: To investigate the association between the change of IGF-2 level in serum after transcatheterarterial chemoembolization (TACE) and hepatocellular carcinoma (HCC) progression, especially in relation tometastasis. Methods: IGF-2 in serum was measured by quantitative sandwich enzyme-linked immunosorbentassaybefore, 3 days and 4 weeks after TACE in 60 patients with HCC. The occurrence of HCC metastasis wasalso evaluated, 3 months after TACE. Results: (1) The average serum level of IGF-2 in the 60 patients withHCC was 136.5 ± 87.3 pg/ml; (2) A tendency for increase was observed with heterogenous uptake of octreotideand portal vein thrombosis. Metastatic foci were found in 37/38 patients in the group with IGF-2 increasing(97.0%), in contrast to 3/22 (13.6%) patients with IGF-2 decrease. Conclusion: The increase of IGF-2 level inserum appears to be associated with the occurrence of metastatic HCC after TACE and chemotherapy.}, keywords = {Octreotide,HCC,IGF-2,TACE,Metastasis,Prognosis}, url = {https://journal.waocp.org/article_26645.html}, eprint = {https://journal.waocp.org/article_26645_3f444024818628342aa1d997691f7b66.pdf} }