@article { author = {}, title = {Acetylation of Retinoblastoma Like Protein2 (Rb2/p130) in Tumor Tissues}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {14}, number = {4}, pages = {2255-2258}, year = {2013}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {The activity of Rb proteins is controlled by post-translational modifications, especially through phosphorylation.Acetylation of Rb2/p130 was reported recently in NIH3T3 cells but its physiological relevance in cell cycle controland tumorigenesis is still unknown. Efforts are underway to investigate possible interplay between Rb2/p130phosphorylation and acetylation. Here we hypothesized that Rb2/p130 acetylation, like p53 acetylation, may playa role in development of the tumor phenotype. The proposed hypothesis regarding acetylation of Rb2/p130 intumor VS normal cells was found to be true in our case study of 36 tumor samples. Statistical analysis of resultssuggest strong correlation among Rb2/p130 acetylation and cancer phenotype.}, keywords = {Pocket proteins,Rb2/p130,Acetylation,Cell cycle,protein modification}, url = {https://journal.waocp.org/article_27609.html}, eprint = {https://journal.waocp.org/article_27609_2982246e9737c1eef192858dc0f4d6a4.pdf} }