@article { author = {}, title = {Proteomic Profiling of Serum from Stage I Lung Squamous Cell Carcinoma Patients}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {14}, number = {4}, pages = {2273-2276}, year = {2013}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Objectives: This study employed proteomic profiling to identify specific tumor markers that might improveearly diagnosis of lung squamous cell carcinoma. Methods: Serum samples were isolated from 30 patients withstage I lung squamous cell carcinoma and 30 age-and gender-matched healthy controls, and proteomic profileswere obtained by matrix-assisted laser desorption ionization time of flight mass spectrometry. Results: Threehighly expressed potential tumor markers were identified in the sera of stage I lung squamous cell carcinomapatients, with molecular weights of 3261.69, 3192.07, and 2556.92 Da. One protein peak with molecular weight3261.69 Da was chosen as the candidate biomarker and identified as a fibrinogen alpha chain through a searchof the IPI, NCBI or SWISS-PROT protein databases. Conclusion: As a potential tumor biomarker, fibrinogenalpha chain may be applicable for the early diagnosis and prognosis of lung squamous cell carcinoma patients.}, keywords = {Lung cancer,Squamous Cell Carcinoma,fibrinogen alpha chain,tumor biomarker}, url = {https://journal.waocp.org/article_27613.html}, eprint = {https://journal.waocp.org/article_27613_0875ccdad4271777c39b4795a5bc2239.pdf} }