@article { author = {}, title = {Ellagic Acid Inhibits Migration and Invasion by Prostate Cancer Cell Lines}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {14}, number = {5}, pages = {2859-2863}, year = {2013}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Polyphenolic compounds from pomegranate fruit extracts (PFEs) have been reported to possessantiproliferative, pro-apoptotic, anti-inflammatory and anti-invasion effects in prostate and other cancers.However, the mechanisms responsible for the inhibition of cancer invasion remain to be clarified. In thepresent study, we investigated anti-invasive effects of ellagic acid (EA) in androgen-independent human(PC-3) and rat (PLS10) prostate cancer cell lines in vitro. The results indicated that non-toxic concentrationsof EA significantly inhibited the motility and invasion of cells examined in migration and invasion assays.The EA treatment slightly decreased secretion of matrix metalloproteinase (MMP)-2 but not MMP-9 fromboth cell lines. We further found that EA significantly reduced proteolytic activity of collagenase/gelatinasesecreted from the PLS-10 cell line. Collagenase IV activity was also concentration-dependently inhibited byEA. These results demonstrated that EA has an ability to inhibit invasive potential of prostate cancer cellsthrough action on protease activity.}, keywords = {ellagic acid,cancer,Invasion,migration,Metastasis}, url = {https://journal.waocp.org/article_27708.html}, eprint = {https://journal.waocp.org/article_27708_a2a6ec18cdf8e1da45d2bab457a8efb6.pdf} }