@article { author = {}, title = {Overexpression of Cyclooxygenase-1 Correlates with Poor Prognosis in Renal Cell Carcinoma}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {14}, number = {6}, pages = {3729-3734}, year = {2013}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {The aim of this study was to evaluate expression of COX-1 in renal cell carcinoma (RCC) and its prognosticvalue. mRNA of COX-1 was detected in 42 paired RCC and adjacent normal tissues with quantitative realtimepolymerase chain reaction (qRT-PCR). Expression of COX-1 was also evaluated in 196 RCC sections and91 adjacent normal tissues with immunohistochemistry. Statistical analysis was performed to assess COX-1expression in RCC and its prognostic significance. The results of qRT-PCR showed mRNA levels of COX-1 inRCC tissues to be significantly higher than that in adjacent normal tissues (p < 0.001). Immunohistochemicalassays also revealed COX-1 to be overexpressed in RCC tissues (p < 0.001). Statistical analysis demonstrated highexpression of COX-1 was correlated with tumour size (p = 0.002), pathological stage (p = 0.003), TNM stage (p= 0.003, 0.007, 0.027, respectively), and tumour recurrence (p < 0.001). Survival analysis indicated patients withhigh expression of COX-1 had shorter survival time (p < 0.001), and COX-1 was an independent predictor. Thisis the first study to reveal overexpression of COX-1 in RRC and point to use as a prognostic marker in affectedpatients.}, keywords = {Cyclooxygenase-1,renal cell carcinoma,Prognostic marker}, url = {https://journal.waocp.org/article_27849.html}, eprint = {https://journal.waocp.org/article_27849_24fca988da89ea49399567b7b5bf7e9a.pdf} }