@article { author = {}, title = {TIAM2 Enhances Non-small Cell Lung Cancer Cell Invasion and Motility}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {14}, number = {11}, pages = {6305-6309}, year = {2013}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Background: TIAM2, a Rac guanine nucleotide exchange factor, is closely associated with cell adherenceand migration. Here, we aimed to investigate the role of TIAM2 in non-small cell lung cancer (NSCLC) cells.Materials and Methods: A small interference RNA (siRNA) was introduced to silence the expression of TIAM2.Invasion and motility assays were then performed to assess the invasion and motility potential of NSCLC cells.GST-pull down assays were used to detect activation of Rac1. Results: TIAM2 was highly expressed in NSCLCcells. Knockdown of TIAM2 inhibited the invasion and motility, and suppressed activation of Rac1. Furtherexperiments demonstrated that knockdown of TIAM2 could up-regulate the expression of E-cadherin, and downregulatethe expression of MMP-3, Twist and Snail. Conclusions: Our data suggest that TIAM2 can promoteinvasion and motility of NSCLC cells. Activation of Rac1 and regulation of some EMT/invasion-related genesmay be involved in the underlying processes.}, keywords = {TIAM2,Invasion,motility,non-small cell lung cancer,EMT,Rac1,MMP-3}, url = {https://journal.waocp.org/article_28290.html}, eprint = {https://journal.waocp.org/article_28290_c8305597f9c87f054792e6a6bb1c1139.pdf} }