@article { author = {}, title = {Clinical Manifestations and Imaging Characteristics of Gliomatosis Cerebri with Pathological Confirmation}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {15}, number = {11}, pages = {4487-4491}, year = {2014}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Objective: To explore the clinical manifestations and imaging characteristics of gliomatosis cerebri to raisethe awareness and improve its diagnostic accuracy for patients. Materials and Methods: Clinical data, imagingcharacteristics and pathological examination of 12 patients with GC from Jan., 2008 to Jan., 2012 were analyzedretrospectively. Results: Patients with GC were clinically manifested with headache, vomiting, repeated seizures,fatigue and unstable walking, most of whom had more than 2 lesions involving in parietal lobe, followed bytemporal lobe, frontal lobe, periventricular white matter and corpus callosum. Magnetic resonance imaging (MRI)showed diffuse distribution, T1-weighted images (T1WI) with equal and low signals and T2-weighted images(T2WI) with bilateral symmetrical high diffuse signals. There was no reinforcement by enhancement scanningand signals were different in diffusion-weighted images (DWI). The higher the tumor staging, the stronger thesignals. Pathological examination showed neuroastrocytoma in which tumor tissues were manifested by infiltrativegrowth in blood vessels and around neurons. Conclusions: In clinical diagnosis of GC, much attention should bepaid to the diffuse distribution of imaging characteristics, incomplete matching between clinical and imagingcharacteristics and confirmation by combining with histopathological examination.}, keywords = {Gliomatosis cerebri,Clinical Manifestation,imaging characteristics,pathological examination}, url = {https://journal.waocp.org/article_28468.html}, eprint = {https://journal.waocp.org/article_28468_34d168d4c8db8827fe218047ee6e675b.pdf} }