@article { author = {}, title = {Immunoregulatory Function of HLA-G in Gastric Cancer}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {14}, number = {12}, pages = {7681-7684}, year = {2013}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Background: Human leukocyte antigen (HLA)-G-positive gastric cancers are associated with poorsurvival, but links with tumor escape mechanisms remain to be determined. Materials and Methods: We usedimmunohistochemistry to investigate HLA-G expression, tumor infiltrating CD8+ T lymphocytes, and Tregcells in 52 gastric cancer patients. Results: There were 29 cancer-related deaths during the follow-up period.Kaplan-Meier analysis indicated that patients with HLA-G-positive (n=16) primary tumors had a significantlypoorer prognosis than patients with HLA-G-negative tumors (n=36, p=0.008). The median survival time was14 months and 47 months, respectively. Patients with high numbers of Tregs and low numbers of CD8+Tlymphocytes in the primary tumor had a poorer prognosis than those with low numbers of Tregs and highnumbers of CD8+T lymphocytes (p=0.034, p=0.043). Multivariate Cox proportional hazard regression analysisshowed that HLA-G expression (hazard ratio: 2.662; 95% confidence interval: 1.242-5.723; p=0.012) and stage(hazard ratio: 2.012;95% confidence interval: 1.112-3.715; p=0.041) were independent unfavorable factors forpatient survival. Conclusions: We found a significant positive correlation between HLA-G expression and thenumber of tumor infiltrating Tregs (p=0.01) and a negative correlation with the number of CD8+T lymphocytes(p=0.041). HLA-G may protect gastric cancer cells from cytolysis by inducing Foxp3+Treg lymphocytes andsuppressing CD8+T lymphocytes.}, keywords = {HLA-G,Gastric cancer,CD8 T lymphocytes,Treg cells}, url = {https://journal.waocp.org/article_28529.html}, eprint = {https://journal.waocp.org/article_28529_a608d2a24ab3bd6492eaf1b7711d3ba2.pdf} }