@article { author = {}, title = {CD3+ CD4+ and CD3+ CD8+ Lymphocyte Subgroups and their Surface Receptors NKG2D and NKG2A in Patients with Nonsmall Cell Lung Cancer}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {15}, number = {6}, pages = {2685-2688}, year = {2014}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Background: To explore the prevalence of lymphocyte subgroups CD3+ CD4+ and CD3+ CD8+ and their surfacereceptors NKG2D and NKG2A in patients with non-small cell lung cancer (NSCLC). Materials and Methods: Atotal of 40 patients with NSCLC were divided into different groups according to different clinical factors (TNMstaging, pathological patterns and genders) for assessment of relations with CD3+ CD4+ and CD3+ CD8+ and thesurface receptors NKG2D and NKG2A of T lymphocytes in peripheral blood by flow cytometry. Results: Patientsin the advanced group had evidently lower levels of CD3+ CD4+ but markedly higher levels of CD3+ CD8+ inperipheral blood than those with early lesions (p<0.05). In addition, NSCLC patients in the advanced group hadobviously higher CD3+ CD4+ NKG2D and CD3+ CD8+ NKG2A expression rates but lower CD3+ CD4+ NKG2A andCD3+ CD8+ NKG2D expression rates (p<0.05). However, there were no significant differences between NSCLCpatients with different genders and pathological patterns in expression levels of lymphocyte subgroups CD3+CD4+ and CD3+ CD8+ and their surface receptors NKG2D and NKG2A. Conclusions: Unbalanced expressionof surface receptors NKG2D and NKG2A in CD3+ CD4+ and CD3+ CD8+ lymphocytes may be associated witha poor prognosis, greater malignancy and immunological evasion by advanced cancers, related to progressionof lung cancer.}, keywords = {non-small cell lung cancer,lymphocyte subgroup,Blood,flow cytometer}, url = {https://journal.waocp.org/article_28979.html}, eprint = {https://journal.waocp.org/article_28979_10842dbf055508acf8cc4d42036d5d9b.pdf} }