@article { author = {}, title = {Association of Matrix Metalloproteinase (MMP)-2 and -9 Expression with Extra-gastrointestinal Stromal Tumor Metastasis}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {15}, number = {10}, pages = {4187-4192}, year = {2014}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Matrix metalloproteinase (MMP)-2 and MMP-9 are important proteases involved in invasion and metastasisof various tumors. Extra-gastrointestinal stromal tumors (EGISTs) are rare neoplasms. This study was performedto assess MMP-2 and MMP-9 expression in EGIST tissue samples for association with clinicopathological datafrom the patients. Twenty-one surgical EGIST tissue specimens were collected for analysis of MMP-2 and MMP-9 expression using immunohistochemistry. MMP-2 and MMP-9 proteins were expressed in all of the epithelialcell types of EGISTs, whereas they were only expressed in 75% of the spindle cell type, although there was nostatistically significant difference (p>0.05). Expression of MMP-2 and MMP-9 proteins was associated with tumorsize, mitotic rate, tumor necrosis, and distant metastasis (p<0.05). MMP-2 expression was linked with MMP-9levels (p<0.05). However, there was no correlation between MMP-9 expression and age, sex, primary site, or cellmorphology in any of these 21 EGIST patients (p>0.05). Moreover, expression of MMP-2 and MMP-9 proteinsincreased with the degree of EGIST risk. This study provided evidence of an association of MMP-2 and MMP-9expression with advanced EGIST behavior.}, keywords = {Extra-gastrointestinal stromal tumor (EGIST),MMP-2,MMP-9,tumor invasion and metastasis,Biomarker}, url = {https://journal.waocp.org/article_29221.html}, eprint = {https://journal.waocp.org/article_29221_28606da5010a0b229321a6b8a219e4b0.pdf} }