@article { author = {}, title = {Association between a Polymorphism in miR-34b/c and Susceptibility to Cancer - a Meta-analysis}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {15}, number = {17}, pages = {7251-7255}, year = {2014}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {MicroRNAs (miRNAs) act as tumor suppressors or promoters in neoplasia by regulating relative geneexpression. The association between a single nucleotide polymorphism (SNP) rs4938723 in miR-34b/c and susceptibility to cancers was inconsistent in previous studies. In this study, we conducted a literature search ofPubMed, Web of Science and Embase to identify all relevant studies in this meta-analysis with 6,036 cases and 6,204 controls. We found that the miR-34b/c rs4938723 polymorphism was significantly associated with increased risk of cancers in the heterozygous model (TC versus TT, OR=1.09, 95% CI=1.01-1.18, P=0.02). Subgroup analysis also revealed increased risk for Asian ethnicity in the heterozygous model (TC versus TT, OR=1.12, 95% CI=1.02-1.22, P=0.02), but decreased risk of colorectal cancer in homozygote model (CC versus TT, OR=0.66, 95% CI=0.47-0.92, P=0.02) and in the recessive model (CC versus TC+TT, OR=0.67, 95% CI=0.48-0.93, P=0.02) by cancer type. The current meta-analysis indicated that the miR-34b/c rs4938723 polymorphism may decreasesusceptibility to colorectal cancer. Well-designed studies with larger sample size are required to further validate the results.}, keywords = {miR,34b/c,rs4938723,Polymorphism,cancer,Meta-analysis}, url = {https://journal.waocp.org/article_29754.html}, eprint = {https://journal.waocp.org/article_29754_246d3adc481fce27eef7f863bafa3ec9.pdf} }