@article { author = {}, title = {Screening of Precancerous Gastric Lesions by Serum Pepsinogen, Gastrin-17, Anti-Helicobacter Pylori and Anti-Caga Antibodies in Dyspeptic Patients over 50 years Old in Guilan Province, North of Iran}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {15}, number = {18}, pages = {7635-7638}, year = {2014}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Background: The aim of this study was to investigate the value of serum gastric markers to differentiatebetween patients with precancerous lesions and nonatrophic chronic gastritis. Materials and Methods: Serumsamples of 128 patients with dyspepsia who were candidates for endoscopic examination were tested forpepsinogen (PG I and PG II), PG I/II ratio, gastrin 17(G-17), anti-Helicobacter pylori (anti-H pylori ) and anti-CagA antibodies. Two sample t-tests, chi-square tests and Pearson’s correlation analyses were used for analysisusing SPSS (version 20). Results: PGI, PG I/II ratio values were decreased significantly in the precancerouslesion group (0.05, 0.001 respectively). The frequency of H pylori infection was significantly (p=0.03) differentbetween the two groups ofthe study. Conclusions: We suggest PGI and the PG I/II ratio as valuable markersfor screening of premalignant gastric lesions.}, keywords = {pepsinogen I,gastrin-17,Helicobacter pylori antibodies,precancerous gastric lesion}, url = {https://journal.waocp.org/article_29814.html}, eprint = {https://journal.waocp.org/article_29814_a9d2f56557ea13e8e5e1d87f88a6205b.pdf} }