@article { author = {}, title = {Clinical Study on Fluvoxamine Combined with Oxycodone Prolonged-Release Tablets in Treating Patients with Moderate to Severe Cancer Pain}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {15}, number = {23}, pages = {10445-10449}, year = {2014}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Objective: To observe treatment effects and safety of fluvoxamine combined with oxycodone prolonged-releasetablets in treating patients with moderate to severe cancer pain. Methods: Patients confirmed pathologicallywith cancer and complicated with moderate to severe pain, were divided into control and experimental groups.Oxycodone prolonged-release tablets, with or without fluvoxamine, were administrated to all study patientsuntil pain relief. Degree of pain relief, dose of oxycodone prolonged-release tablets, side effects and quality oflife were compared before and after treatment. Results: In total, 120 patients were recruited. No statisticallysignificant difference was detected regarding age, gender, types of cancer, KPS between two groups of patients(P> 0.05). Baseline pain score of patients with moderate pain in treatment and control group was 4.9±0.8 and5.1±0.8, respectively; and decreased to 1.8±1.1 and 1.2±1.1 after treatment, respectively. Pain intensity wassignificantly reduced in the treatment group (P =0.028). Average daily consumption of oxycodone prolongedreleasetablets was (54.0±19.6) mg and (44.7± 18.7) mg respectively, which is lower in treatment grpup than incontrol group, but the difference was not statistically significant (P=0.065). Baseline pain score of patients withsevere pain in treatment and control groups were 8.3±1.1 and 8.3±1.1, respectively; and pain intensity aftertreatment decreased to 2.9±1.0 and 2.3±1.0. Pain intensity was significantly reduced in the treatment group,with statistical significance (P =0.026). Average daily consumption of oxycodone prolonged-release tablets was(132.0±42.2) mg and (110.7±33.9) mg, respectively, which is lower in treatment group than in control group, andthe difference was statistically significant (P=0.035). In terms of quality of life, patients in treatment group hadbetter performance status, daily activity, mood, and sleep than that in control group (P < 0.05). Patients in twogroups had similar side effects, eg., constipation, nausea/vomiting, lethargy, dizziness, itchy skin, dysuria, andataxia. Lower incidence of nausea/vomiting, lethargy, was obtained from patients in treatment than in controlgroup, while significant low constipation was observed in treatment than in control group (35.0% vs 49.2%,P=0.026). Conclusion: Fluvoxamine combined with oxycodone prolonged-release tablets could be more effectivein treating patients with cancer pain, and could reduce the dosage of oxycodone prolonged-release tablets andthus be associated with lower side effects, and improved quality of life.}, keywords = {cancer pain,fluvoxamine,oxycodone}, url = {https://journal.waocp.org/article_30139.html}, eprint = {https://journal.waocp.org/article_30139_ac24f56a34c485533841439a74c1f5a6.pdf} }