@article { author = {}, title = {Dietary Aloe Vera Gel Powder and Extract Inhibit AzoxymethaneinducedColorectal Aberrant Crypt Foci in Mice Fed a Highfat Diet}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {16}, number = {2}, pages = {683-687}, year = {2015}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Aloe vera gel exhibits protective effects against insulin resistance as well as lipid-lowering and anti-diabeticeffects. The anti-diabetic compounds in this gel were identified as Aloe-sterols. Aloe vera gel extract (AVGE)containing Aloe-sterols has recently been produced using a new procedure. We previously reported that AVGEreduced large-sized intestinal polyps in Apc-deficient Min mice fed a high fat diet (HFD), suggesting that Aloevera gel may protect against colorectal cancer. In the present study, we examined the effects of Aloe vera gelpowder (AVGP) and AVGE on azoxymethane-induced colorectal preneoplastic aberrant crypt foci (ACF) in micefed a HFD. Male C57BL/6J mice were given a normal diet (ND), HFD, HFD containing 0.5% carboxymethylcellulose solution, which was used as a solvent for AVGE (HFDC), HFD containing 3% or 1% AVGP, and HFDCcontaining 0.0125% (H-) or 0.00375% (L-) AVGE. The number of ACF was significantly lower in mice given3% AVGP and H-AVGE than in those given HFD or HFDC alone. Moreover, 3% AVGP, H-AVGE and L-AVGEsignificantly decreased the mean Ki-67 labeling index, assessed as a measure of cell proliferation in the colonicmucosa. In addition, hepatic phase II enzyme glutathione S-transferase mRNA levels were higher in the H-AVGEgroup than in the HFDC group. These results suggest that both AVGP and AVGE may have chemopreventiveeffects on colorectal carcinogenesis under the HFD condition. Furthermore, the concentration of Aloe-sterolswas similar between 3% AVGP and H-AVGE, suggesting that Aloe-sterols were the main active ingredients inthis experiment.}, keywords = {Aloe vera gel extract (AVGE),Aloe-sterols,aberrant crypt foci (ACF),high-fat diet (HFD)}, url = {https://journal.waocp.org/article_30144.html}, eprint = {https://journal.waocp.org/article_30144_ecbbd8b9fd095f5cad7de032a84d9d9d.pdf} }