@article { author = {}, title = {MicroRNA-328 Inhibits Proliferation of Human Melanoma Cells by Targeting TGFΒ2}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {16}, number = {4}, pages = {1575-1579}, year = {2015}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Some microRNAs (miRNAs) have been shown to act as oncogenes or tumor suppressor genes in humanmelanomas. miR-328 is upregulated in blood cells of melanoma patients compared to in healthy controls. Thissuggests a role for miR-328 in melanoma that warrants investigation. In this study, we demonstrated miR-328levels to be dramatically decreased in human melanoma cell lines. Moreover, forced expression of miR-328inhibited proliferation and induced G1-phase arrest of the SK-MEL-1 melanoma cell line. We identified TGFΒ2as a direct target gene for miR-328 using a fluorescent reporter assay and western blotting. Levels of TGFΒ2were dramatically increased in human melanoma cell lines and were inversely correlated with the miR-328expression level. Our findings provide new insights into the mechanisms of human melanoma development,indicating that miR-328 has therapeutic potential for this disease.}, keywords = {miR-328,TGFΒ2,Melanoma,Proliferation}, url = {https://journal.waocp.org/article_30609.html}, eprint = {https://journal.waocp.org/article_30609_18b5e16ac853010b65de7c2275b37d37.pdf} }