@article { author = {}, title = {Preoperative Neutrophil to Lymphocyte Ratio as a Prognostic Factor in Patients with Non-metastatic Renal Cell Carcinoma}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {16}, number = {9}, pages = {3703-3708}, year = {2015}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Background: The neutrophil-to-lymphocyte ratio (NLR) is a strong predictor of mortality in patients withcolorectal, lung, gastric cancer, pancreatic and metastatic renal cell carcinoma. We here evaluated whetherpreoperative NLR is an independent prognostic factor for non-metastatic renal cell carcinoma (RCC). Materialsand Methods: Data from 327 patients who underwent curative or palliative nephrectomy were evaluatedretrospectively. In preoperative blood routine examination, neutrophils and lymphocytes were obtained. Thepredictive value of NLR for non-metastatic RCC was analyzed. Results: The NLR of 327 patients was 2.72±2.25.NLR <1.7 and NLR ≥1.7 were classified as low and high NLR groups, respectively. Chi-square test showed thatthe preoperative NLR was significantly correlated with the tumor size (P=0.025), but not with the histologicalsubtype (P=0.095)and the pT stage (P=0.283). Overall survival (OS) and disease-free survival (DFS) wereassessed using the Kaplan-Meier method. Effects of NLR on OS (P=0.007) and DFS (P=0.011) were significant. Toevaluate the independent prognostic significance of NLR, multivariate COX regression models were applied andidentified increased NLR as an independent prognostic factor for OS (P=0.015), and DFS (P=0.019). Conclusions:Regarding patient survival, an increased NLR represented an independent risk factor, which might reflect ahigher risk for severe cardiovascular and other comorbidities. An elevated blood NLR may be a biomarker ofpoor OS and DFS in patients with non-metastatic RCC.}, keywords = {Non-metastatic renal cell carcinoma,neutrophil-to-lymphocyte ratio,Overall survival,disease-free survival}, url = {https://journal.waocp.org/article_30976.html}, eprint = {https://journal.waocp.org/article_30976_92af96b8bd5354cb780b72e1e7879f8f.pdf} }