@article { author = {}, title = {Interferon-γ and Interleukin-10 Gene Polymorphisms are not Predictors of Chronic Hepatitis C (Genotype-4) Disease Progression}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {16}, number = {12}, pages = {5025-5030}, year = {2015}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Immunoregulatory cytokines have an influence on hepatitis C virus (HCV) infection outcome. This studyaimed to determine whether single nucleotide polymorphisms (SNP) in IFN- γ and IL-10 genes are associatedwith susceptibility and/or are markers of prognosis regarding chronic hepatitis C outcomes. IFN γ (+874T/A)and IL-10 (-1082G/A) genotypes were determined in 75 HCV genotype 4 patients with different disease severities(chronic hepatitis, n=25, liver cirrhosis and hepatocellular carcinoma (HCC) on top of liver cirrhosis, n=50)and 25 healthy participants using allele-specific polymerase chain reaction. No statistical differences in alleleor genotype distributions of IFN γ and IL-10 genes were detected between patients and controls or betweenpatientgroups. No significant difference in the frequency of IL-10 SNP at position -1082 or IFN-γ at position+874T/A was found between chronic HCV genotype 4 and with progression of disease severity in liver cirrhosisor HCC. In conclusion; interferon-γ and interleukin-10 gene polymorphisms are not predictors of diseaseprogression in patients with chronic hepatitis C (Genotype-4).}, keywords = {Chronic hepatitis C,Single nucleotide polymorphism,IFN-γ,IL-10,HCV genotype 4}, url = {https://journal.waocp.org/article_31206.html}, eprint = {https://journal.waocp.org/article_31206_27d63e36be2bc9a9eac309c0a41de126.pdf} }