@article { author = {Abdelgawad, Iman and Radwan, Noha and Shafik, Roxan and Shokralla, Hala}, title = {Significance of Proliferation Markers and Prognostic Factors in Egyptian Patients with Multiple Myeloma}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {17}, number = {3}, pages = {1351-1355}, year = {2016}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {}, abstract = {Background: Multiple myeloma (MM) is influenced by genetic and micro-environmental changes. Malignant plasma cells produce an abnormal monoclonal immunoglobulin, as well as cytokines, such as IL-10 and IL-6 which stimulate cells of the bone marrow microenvironment (BMM) and cause dysfunction and failure of many organs. B cell activating factor (BAFF), IL6 and IL10 are known to influence the growth and survival of malignant clones. Aim: The objectives of the present study were to investigate the circulating levels of BAFF , IL-10 and IL-6, correlate them with well-known parameters of disease activity in patients with MM, and to detect their impact on patients' survival. Materials and Methods: This study was conducted on 89 newly diagnosed MM patients and seventy apparently healthy volunteers as a normal control group. BAFF, IL6, IL10 were measured by ELISA for both groups and survival analysis was performed for all patients. Results: Studied markers were higher in the MM patients compared to the normal control subjects. Patients survival was improved by high serum BAFF levels. Conclusions: High levels of BAFF were found to improve patients' survival. BAFF and IL-6 can be considered probable diagnostic markers for MM.}, keywords = {}, url = {https://journal.waocp.org/article_32243.html}, eprint = {https://journal.waocp.org/article_32243_2fe741661cfb19c6f9fa932b4cc6ae40.pdf} }