@article { author = {Ud Din, Nasir and Barakzai, Abrar and Memon, Aisha and Hasan, Sheema and Ahmad, Zubair}, title = {Atypical Teratoid/ Rhabdoid Tumor of Brain: a Clinicopathologic Study of Eleven Patients and Review of Literature}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {18}, number = {4}, pages = {949-954}, year = {2017}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.22034/APJCP.2017.18.4.949}, abstract = {Background: Atypical teratoid/ rhabdoid tumor (AT/RT) is a rare aggressive embryonal central nervous system(CNS) tumor of infancy and early childhood. Majority of the cases arise in the posterior fossa, and remaining in thecerebrum. Aims: To analyze the clinicopathologic features of AT/RT on a cohort of cases. Materials and methods:All reported cases of AT/RT at the Department of Pathology and Laboratory Medicine, Aga Khan University Hospital(AKUH) from 2007 to 2016 were reviewed for clinical and pathological features. Immunohistochemical stain for INI-1was performed in all 11 cases. Follow up was obtained. Results: A total of 11 cases were identified. Seven patients weremales and 4 were females. The ages ranged from 1 month to 48 months (mean 26.6 months). Six tumors were locatedin the cerebrum and 3 in the posterior fossa. Exact Location was not known in 2 cases. Histologically, rhabdoid cellswere present in sheets in variable proportions in five cases, Medulloblastoma and PNET like areas were seen in 2 caseseach. Immunohistochemical stains EMA (10/10), vimentin (7/7), CKAE1/AE3 (8/9), and CD99 (3/4), GFAP (6/10),ASMA (3/4) and synaptophysin (3/4) were positive in varying proportions while desmin was negative in all 6 cases inwhich it was performed. All 11 tumors lacked immunoreactivity for INI-1 protein. Four patients died of disease witha follow up ranging from 5 to 24 months. Conclusions: AT/RT is a rare highly aggressive embryonal tumor of CNS.A male predominance was noted in our series. We report the first and largest series from Pakistan.}, keywords = {Atypical teratoid/rhabdoid tumor,posterior fossa,cerebrum,INI 1}, url = {https://journal.waocp.org/article_46239.html}, eprint = {https://journal.waocp.org/article_46239_33481c493a65e7e0edb1d3799a7935fa.pdf} }