@article { author = {Heidari, Zahra and Nikbakht, Mahdi and Mashhadi, Mohammad Ali and Jahantigh, Mahdi and Mansournia, Nasrin and Sheikhi, Vahid and Mansournia, Mohammad Ali}, title = {Vitamin D Deficiency Associated with Differentiated Thyroid Carcinoma: A Case- Control Study}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {18}, number = {12}, pages = {3419-3422}, year = {2017}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.22034/APJCP.2017.18.12.3419}, abstract = {  Objective: In recent decades, the incidence of thyroid cancer has increased throughout the world. It is unclear whether factors such as vitamin D deficiency may have been involved in this increase. The present case-control study was conducted to examine any association between Vitamin D deficiency and thyroid cancers. Methods: The study was conducted on 85 patients with differentiated thyroid cancer diagnosed based on fine needle aspiration biopsy as the case group and 85 healthy controls. Serum levels of vitamin D were evaluated before thyroidectomy. For each patient in the case group, one healthy euthyroid person without any thyroid nodules from the general population matched based on season, sex, age (± 1 year) and BMI (± 1) was selected. Finally, 85 pairs were obtained considering inclusion and exclusion criteria. Thyroid function, thyroid antibodies and serum vitamin D were assessed and thyroid sonography was performed in all participants. Results: In the patient group, 72 (85%) were female and 13 (15%) were male. The mean (SD) serum vitamin D level was 8.00 (±3.7) in patient group, as compared to 13.4 (±7.90) in the control group, the difference being significant (OR: 6, 95 % CI: 1.02-113.3; P=0.046). Conclusion: A significant association was noted between vitamin D deficiency and differentiated thyroid cancer. Further studies with a prospective design are necessary to further define the roles of this factor.}, keywords = {Vitamin D,Thyroid cancer,etiology}, url = {https://journal.waocp.org/article_53787.html}, eprint = {https://journal.waocp.org/article_53787_417f88c8846f5750862e936831f25d4c.pdf} }