@article { author = {Shamsdin, Seyedeh Azra and Karimi, Mohammad Hossein and Hosseini, Seyed Vahid and Geramizadeh, Bita and Fattahi, Mohamad Reza and Mehrabani, Davood and Moravej, Ali}, title = {Associations of ICOS and PD.1 Gene Variants with Colon Cancer Risk in The Iranian Population}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {19}, number = {3}, pages = {693-698}, year = {2018}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.22034/APJCP.2018.19.3.693}, abstract = {Background: Positive and negative co-stimulatory molecules are important factors determining the outcomeof immune responses to the presence of tumors. Since co-stimulatory molecule expression may be affected by genepolymorphisms, we aimed to investigate associations between variants of PD.1 and ICOS and susceptibility to coloncancer. Material and methods: ICOS (-693A/G), ICOS (+1720C/T) and PD.1 (-538G/A) gene polymorphisms wereevaluated by the PCR-RFLP method in 76 colon cancer patients and 73 healthy controls. Results: The frequenciesof the GG genotype and the G allele at position -693 of the ICOS gene were significantly higher in the patient group(P=0.014 and p=0.0002), while the AA genotype was significantly more common in controls (P=0.0016). At position-538 of PD.1, GG genotype and G allele frequencies were higher in the patient group (PAA and also AG genotypes significantly predominated in controls (Pand alleles of ICOS at position +1720. Frequencies of GCG and GTG haplotypes were higher in patients comparedto those of controls (P=0.016 and P<0.0001), while, frequencies of GTA, ATA and ATG haplotypes were higher incontrols (P=0.0017, Ppatients compared to controls (P=0.0147 and P=0.0071). Conclusion: Our study clarified that PD.1 (-538G/A) andICOS (-693A/G) gene polymorphisms can be considered as genetic risk factors for the development of colon canceramong Iranian patients.}, keywords = {Key words: Colon cancer,PD.1,ICOS,Polymorphism}, url = {https://journal.waocp.org/article_57761.html}, eprint = {https://journal.waocp.org/article_57761_9d975b138fc9973784975eaa7e4a20b7.pdf} }