@article { author = {Lavaee, Fatemeh and Zareh, Sahar and Mojtahedi, Zahra and Malekzadeh, Mahyar and Khademi, Bijan and Ghaderi, Abbas}, title = {Serum CXCL12, but not CXCR4, Is Associated with Head and Neck Squamous Cell Carcinomas}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {19}, number = {4}, pages = {901-904}, year = {2018}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.22034/APJCP.2018.19.4.901}, abstract = {Background: Squamous cell carcinoma (SCC) is the most frequent malignancy of the head and neck (HN) region.We here evaluated associations of stromal cell derived factor-1 (SDF-1or CXCL12) and its receptor, CXCR4, withHNSCCs. Materials and Methods: Sixty newly diagnosed HNSCC patients were enrolled in the patient group, and 28healthy individuals in the control group. Plasma levels of CXCL12 and CXCR4 were measured using ELISA kits.Results: There was a significant difference in mean CXCL12, but not CXCR4, plasma levels between the patient andcontrol groups (P=0.0001). No significant associations were found between mean plasma levels of either CXCL12 orCXCR4 with age, gender, tumor site, tumor size, lymph-node involvement or tumor stage. Conclusion: For the firsttime, our findings demonstrate a significant association between serum CXCL12 but not CXCR4 levels and HNSCCs.}, keywords = {CXCL12,CXCR4, HNSCC, Serum}, url = {https://journal.waocp.org/article_59850.html}, eprint = {https://journal.waocp.org/article_59850_378cd5adef8bc2d147349f754a049fd8.pdf} }