@article { author = {Pedro, Nayara Fernandes and Biselli, Joice Matos and Maniglia, José Victor and Neto, Dalisio and Pavarino, Erika Cristina and Goloni-Bertollo, Eny Maria and Biselli-Chicote, Patricia Matos}, title = {Candidate Biomarkers for Oral Squamous Cell Carcinoma: Differential Expression of Oxidative Stress-Related Genes}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {19}, number = {5}, pages = {1343-1349}, year = {2018}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.22034/APJCP.2018.19.5.1343}, abstract = {Background: Alteration in the biotransformation of exogenous compounds can result in production of reactiveoxygen species (ROS), which can predispose cells to malignant transformation in the head and neck. This study aimedto evaluate the expression of genes involved in antioxidant metabolism in the oral squamous cell carcinoma (OSCC).Methods: The expression of eighty-four genes was evaluated in OSCC and non-tumor tissues by quantitative real-timepolymerase chain reaction using the TaqMan Gene Expression Array. The biological mechanisms related tothe differentially expressed genes were investigated using Gene – NCBI, KEGG, UNIPROT and REACTOME databases.Results: Twenty-one genes encoding enzymes involved in antioxidant metabolism were differentially expressed inthe OSCC case. Four genes (ATOX1, PRDX4, PRNP, and SOD2) were up-regulated, and seventeen (ALOX12, CAT,CSDE1, DHCR24, DUOX1, DUOX2, EPHX2, GLRX2, GPX3, GSR, GSTZ1, MGST3, PRDX1, OXR1, OXSR1,SOD1, and SOD3) were down-regulated. We identified 14 possible novel biomarkers for OSCC. The differentiallyexpressed genes appeared related to important biological processes involved in carcinogenesis, such as inflammation,angiogenesis, apoptosis, genomic instability, invasion, survival, and cell proliferation. Conclusions: Our studyidentified novel biomarkers which might warrant further investigation regarding OSCC pathogenesis since the alteredexpression in the genes can modulate biological processes related to oxidative stress and predispose cells to malignanttransformation in the oral cavity.}, keywords = {oxidative stress,Biomarker,carcinoma squamous cell,oral cavity,carcinogens}, url = {https://journal.waocp.org/article_60722.html}, eprint = {https://journal.waocp.org/article_60722_16442c8fe68992a07b4416fcadd3f29a.pdf} }