@article { author = {Rahmati, Shoboo and Azami, Milad and Delpisheh, Ali and Hafezi Ahmadi, Mohammad Reza and Sayehmiri, Koroush}, title = {Total Calcium (Dietary and Supplementary) Intake and Prostate Cancer: a Systematic Review and Meta-analysis}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {19}, number = {6}, pages = {1449-1456}, year = {2018}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.22034/APJCP.2018.19.6.1449}, abstract = {Background: Controversial results have been reported concerning the influence of calcium intake on prostate cancerrisk. The aim of this study was to determine any association between total calcium (in the diet and in supplements) intakeand prostate cancer. Materials and Methods: The present systematic review and meta-analysis study was carried outfollowing a PRISMA guidelines. Two reviewers independently using MeSH keywords searched international databasesincluding PubMed, Science Direct, Cochrane, EMBASE, Web of Science, CINAHL, EBSCO and search engines suchas Google Scholar. The searches were performed without any time limit until May 2016. The results were pooledusing a random effects model and homogeneity was confirmed using the Q test and I2 index. Subgroup analyses wasperformed according to continents and study designs. The data were analyzed using STATA software version 3.2, withpfinal meta-analysis. The main age range of the participants was 50 to 70 years. The relative risks (RR) for total calciumwith total prostate cancer, localized prostate cancer, and advance prostate cancer were estimated to be 1.15 (95% CI:1.04-3.46), 1.05 (95% CI: 0.96-1.14), and 1.15 (95% CI: 0.89-1.50), respectively. Only the relationship between totalcalcium and total prostate cancer was significant (P<0.05). Conclusions: High calcium intake can be considered as arisk factor for total prostate cancer. Therefore, calcium intake might be a target for prevention.}, keywords = {Calcium,Prostate Cancer,systematic review and meta-Analysis}, url = {https://journal.waocp.org/article_63261.html}, eprint = {https://journal.waocp.org/article_63261_8e14694a55b7c045f42b1d1a537f0518.pdf} }