@article { author = {Hasson, S S and H Al-Shubi, A S and Al-Busaidi, J Z and Al-Balushi, M S and Hakkim, F L and Rashan, L and Aleemallah, G M and Al-Jabri, A A}, title = {Potential of Aucklandia Lappa Decne Ethanolic Extract to Trigger Apoptosis of Human T47D and Hela Cells}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {19}, number = {7}, pages = {1917-1925}, year = {2018}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.22034/APJCP.2018.19.7.1917}, abstract = {Breast and cervical cancers are global health concerns and major cause of deaths among women. Current treatmentssuch as chemotherapy are associated with several drawbacks that limit their effectiveness. Several anticancer remedieshave been found with natural products in the past and the search continues for more examples. Cytotoxic naturalcompounds may have considerable benefits for cancer therapy either in potentiating the impact of chemotherapy orcurtailment of harmful effects. Therefore, discovery and identification of new drugs for breast and cervical cancertreatment are of high priority. The present study addressed the potential role of the ALD (Aucklandia lappa Decne) insuppressing proliferation of T-47D, HeLa and HEp-2 cells in comparison with the non-cancer HCC1937 BL cell line.Treatment with an ALD extract of T-47D, HeLa, and HEp-2 cells resulted in reduction in cell viability in MMT assays.Furthermore, lyophilized ALD principally suppressed cancer cell line growth and proliferation through induction ofeither intrinsic or extrinsic apoptotic pathways as demonstrated by significantly suppressed release of LDH, and NOproduction in a dose-dependent manner, and activation of death receptors in T-47D and HeLa cells but not the HEp-2cell line. Interestingly, lyophilized ALD significantly (p<0.005) repressed the growth of HEp-2 and T-47D cells aftertreatment for 48hrs while 24hrs treatment significantly suppressed T-47D and HeLa cells. We report for the first timethat lyophilized ALD selectively influences apoptosis through alternative apoptotic pathways in both breast and cervicalhuman cancer cells.}, keywords = {breast cancer,Cervical cancer,anticancer activity,Oman}, url = {https://journal.waocp.org/article_65208.html}, eprint = {https://journal.waocp.org/article_65208_404e424b2af9de85567495e72c1f39f7.pdf} }