@article { author = {Dolatkhah, Roya and Somi, Mohammad Hossein and Shabanloei, Reza and Farassati, Faris and Fakhari, Ali and Dastgiri, Saeed}, title = {Main Risk Factors Association with Proto-Oncogene Mutations in Colorectal Cancer}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {19}, number = {8}, pages = {2183-2190}, year = {2018}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.22034/APJCP.2018.19.8.2183}, abstract = {Objective: Although several factors have been shown to have etiological roles in colorectal cancer, few investigationshave addressed how and to what extent these factors affect the genetics and pathology of the disease. Precise relationshipswith specific genetic mutations that could alter signaling pathways involved in colorectal cancer remain unknown.We therefore aimed to investigate possible links between lifestyle, dietary habits, and socioeconomic factors and specificmutations that are common in colorectal cancers. Methods: Data were retrieved from a baseline survey of lifestyle factors,dietary behavior, and SES, as well as anthropometric evaluations during a physical examination, for 100 confirmedprimary sporadic colorectal cancer patients from Northwest Iran. Results: High socioeconomic status was significantlyassociated with higher likelihood of a KRAS gene mutation (P < 0.05) (odds ratio: 3.01; 95% CI: 0.69–13.02). Consumingcarbohydrates and alcohol, working less, and having a sedentary lifestyle also increased the odds of having a KRASmutation. Conclusion: Although research has not yet described the exact relationships among genetic mutations withdifferent known risk factors in colorectal cancer, examples of the latter may have an impact on KRAS gene mutations.}, keywords = {colorectal cancer,risk factors,KRAS,Regression}, url = {https://journal.waocp.org/article_66140.html}, eprint = {https://journal.waocp.org/article_66140_7cffbe6b6734f7ac9e592845b729f0a4.pdf} }