@article { author = {El Din Fouad, Neveen Bahaa and Ibrahim, Noha Yehia and Abdel Aziz, Rania Salah and Ibrahim, Sarah Khalid}, title = {CD200 Expression in Diagnostic and Prognostic Assessment of Mature B Cell Lymphophoproliferative Neoplasms}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {19}, number = {12}, pages = {3383-3392}, year = {2018}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.31557/APJCP.2018.19.12.3383}, abstract = {Background: Multiparameter flow cytometry is a useful tool for diagnostic evaluation of mature B-cell neoplasms(MBN). Recently, it has been shown that assessment of CD200 expression may improve the distinction betweenchronic lymphocytic leukemia (CLL; CD200 positive) and mantle cell lymphoma (MCL; CD200 negative), but anypotential as a prognostic marker for CLL remains to be established. Materials and methods: This cross sectionalstudy was conducted on sixty-seven patients newly diagnosed as having mature B-cell lymphoproliferative disordersLevels of CD 200 in lymphoma cells were assessed. Results: CD200 was consistently expressed in CLL and hairycell leukemia B cells, but not in MCL cells. Heterogeneous expression was noted in other CD5 positive Non-Hodgkinlymphomas. High CD200 expression (≥50%) was associated with a higher CD5, 19 and CD23 expression, olderage, higher TLC and absolute lymphocyte count, hepatomegaly, splenomegaly and a higher Rai stage. There wereno significant correlations between CD200 expression and response to treatment. Conclusion: CD200 could be of highvalue in distinguishing CLL, MCL, and atypical CLL. CD200 expression can also be of prognostic and therapeuticvalue in CLL cases.}, keywords = {CD200,Mature B-cell neoplasms,Flowcytometry,CLL}, url = {https://journal.waocp.org/article_77404.html}, eprint = {https://journal.waocp.org/article_77404_5f3dea8c8f9e1e7e7776e6a8296f94bb.pdf} }