@article { author = {Khan, Muhammad Rahil and Ahmad, Arsalan and Kayani, Naila and Minhas, Khurram}, title = {Expression of PAX-5 in B Cell Hodgkin and Non Hodgkin Lymphoma}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {19}, number = {12}, pages = {3463-3466}, year = {2018}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.31557/APJCP.2018.19.12.3463}, abstract = {Background: B-cell malignancies including Precursor B-cell lymphoblastic lymphoma/leukemia and HodgkinLymphoma show a wide spectrum of B-cell differentiation from early stage B-cell precursors to mature B-cells ending interminal differentiation to plasma cells. Pan-B-cell antigens routinely used for the diagnosis of B-cell lymphoma, includeCD19, CD20, CD22 and CD79a.PAX-5 protein, also known as B-cell-specific activation protein is a B-cell-specifictranscription factor; essential for commitment and functional maintenance used in the diagnosis of B cell Hodgkinand non-Hodgkin lymphoma. PAX-5 show nuclear positivity in B cell lymphomas and moderate (dim) positivity inHodgkinlymphoma Reed Sternberg cells make this marker ideal for diagnosing B cell malignances. Objective: Todetermine the expression of PAX-5 in B cell Hodgkin and non-Hodgkin Lymphoma in order to improve the diagnosisof B-cell lymphomas. Methods: In this Prospective study, all the cases of B cell lymphoma diagnosed at The AgaKhan University Hospital, Karachi from July 2010 to July 2011were included. A panel of Immunohistochemical stainwas performed in all cases along with additional PAX- 5 stain with appropriate controls. Results: Total 125 cases wereincluded. Hodgkin Lymphoma (Mixed cellularity) was the commonest B-cell lymphoma subtype, 32 (25%) cases.Other common subtypes included Hodgkin lymphoma (Nodular sclerosis subtype), diffuse large B-cell lymphomaand B lymphoblastic lymphoma. Conclusion: This study demonstrates that PAX-5 is the most sensitive and reliableimmuhohistochemicalmarker in the diagnosis of B cell Hodgkin and non-Hodgkin lymphoma.}, keywords = {KEYWORDS: PAX-5,Hodgkin lymphoma,Non Hodgkin Lymphoma}, url = {https://journal.waocp.org/article_80032.html}, eprint = {https://journal.waocp.org/article_80032_885801f5e5aa2368cb30ccc577a37dde.pdf} }