@article { author = {Hashmi, Atif Ali and Mudassir, Ghazala and Irfan, Muhammad and Hussain, Zubaida Fida and Hashmi, Shumaila Kanwal and Asif, Huda and Nisar, Laila and Naeem, Maheen and Faridi, Naveen}, title = {Prognostic Significance of High Androgen Receptor Expression in Prostatic Acinar Adenocarcinoma}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {20}, number = {3}, pages = {893-896}, year = {2019}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.31557/APJCP.2019.20.3.893}, abstract = {Background: Quantitative immunohistochemical expression of Androgen receptor (AR) has not been evaluatedas a prognostic biomarker of prostate cancer in our population, therefore in the current study we aimed to evaluatethe association of AR expression in prostatic acinar adenocarcinoma with various prognostic parameters like tumorquantification, Gleason score, WHO grade group and perineural invasion. Methods: Total 121 cases of biopsy provenprostatic acinar adenocarcinoma were selected from records of pathology department archives from January 2013 tillDecember 2017. Hematoxylin and eosin stained slides and paraffin blocks were retrieved and new sections were cutwhere necessary. Slides of all cases were reviewed by two senior histopathologists and pathologic characteristics likeGleason score, WHO grade, tumor quantification, perineural and lymphovascular invasion were evaluated. Androgenreceptor immunohistochemistry was applied on all cases. Results: Low AR expression was noted in 53 cases (43.8%)while high AR expression was seen in 68 cases (56.2%). Significant association of AR expression was noted with totalGleason score, WHO grade and percentage of tissue involvement (tumor quantification). Univariate binary logisticregression showed patients with low Gleason scores (scores 6,7 or 8) and low WHO grade (grade 1, 2 or 3) were lesslikely to express high AR expression in comparison to high Gleason score (score 9) and high WHO grade group(grade 5) respectively. Similarly, cases with low tissue involvement by carcinoma (<50%) were less likely to showhigh AR expression in comparison to cases with >50% tissue involvement by carcinoma. Conclusion: Significantassociation of AR expression was noted with total Gleason score, WHO grade and percentage of tissue involvement(tumor quantification) which are among the most important markers of tumor progression; therefore we suggest that ARexpression should be performed in patients with prostatic adenocarcinoma for prognostic stratification of the patients.}, keywords = {Androgen Receptor,AR,Prostatic carcinoma,Gleason score,WHO grade group}, url = {https://journal.waocp.org/article_82668.html}, eprint = {https://journal.waocp.org/article_82668_8552ba3a70173f43647b0c9207a54049.pdf} }