@article { author = {Obhielo, Ehiozogie and Ezeanochie, Michael and Olokor O, Oghenefegor and Okonkwo, Anthony and Gharoro, Etedafe}, title = {The Relationship between the Serum Level of Selenium and Cervical Intraepithelial Neoplasia: A Comparative Study in a Population of Nigerian Women}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {20}, number = {5}, pages = {1433-1436}, year = {2019}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.31557/APJCP.2019.20.5.1433}, abstract = {Objective: To determine the relationship between the serum level of selenium and cervical intraepithelial neoplasia(CIN). Methods: A case controlled study that compared the serum level of selenium in 45 women with CIN (cases) to45 women (age matched controls) with normal cervical cytology. Socio-demographic data and information on knownrisk factors for cervical cancer among the sample was compared between both groups using inferential statistics.Results: There was no significant difference in the mean selenium values between the cases and controls [p- 0.076,95% CI (-15.08 – 0.76)]. However, subgroup analysis showed a statistically significant difference between patientswith normal cervical cytology, CIN I, II and III (p= 0.021). In addition, there was also significant difference in theselenium level between women with normal cervical cytology and CIN III (p value = 0.016) with a significant inverselinear trend (p= 0.025). Conclusion: With increasing severity of CIN, a significant reduction in the level of seleniumin serum was observed. This reducing value of serum selenium, a surrogate marker for increased oxidative stress, maybe important factor for the development of persistent HPV infection and in particular high grade CIN III lesions. Thisobservation requires further research.}, keywords = {selenium,cervical intraepithelial neoplasia,cancer,Nigeria}, url = {https://journal.waocp.org/article_87380.html}, eprint = {https://journal.waocp.org/article_87380_223358481626376a3a04f4253f9f3b33.pdf} }