@article { author = {Yousif, Hala Mohammed and Albasri, Abdulkader Mohammed and Alshanqite, Mariam Mohammed and Missawi, Hashim Mohamed}, title = {Histopathological Patterns and Characteristics of Abnormal Cervical Smear in Madinah Region of Saudi Arabia}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {20}, number = {5}, pages = {1303-1307}, year = {2019}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.31557/APJCP.2019.20.5.1303}, abstract = {Cervical cancer is a major public health problem that continues to be one of the leading female genital cancersworldwide. In the kingdom of Saudi Arabia (KSA), cervical cancer ranks the fifteenth most frequent cancer amongfemales. This study is the first published research study addressing the screening of cervical cancer in Madinah regionof KSA. Aim: To evaluate the abnormal cytological entities detected by cervical Pap smear in Madinah region of KSAand to compare the results with other national and international studies. Methods: This retrospective case-control studywas conducted in the Departments of Obstetrics and Gynecology, and Histopathology at the Maternity and ChildrenHospital (MCH), Madinah, KSA from January 2013 to December 2015. Results: Of the 1594 cases reviewed, only38 cases (2.4%) had epithelial cell abnormalities. High grade squamous intraepithelial lesions (HSIL) and low gradesquamous intraepithelial lesions (LSIL) were the most common diagnosis categories, and cervical cancer accountedfor 36.8% of the total cases for each, followed by atypical squamous cells of uncertain significance (ASCUS) foundin (15.9%). Squamous cell carcinoma (SCC ) was found in (5.3%) of the cases. Patients with abnormal epithelialchanges had higher parity (P=0.021) and presented more with a complaint of postcoital bleeding (P<0.0001), tend tohave abnormal cervical appearance (P=0.004), more likely bleeding on touch (P=0.001) and associated with cervicalerosion (P=0.014). Conclusion: The study showed a relatively low prevalence of epithelial cell lesions. These lesionswere mainly squamous cell lesions harbored by females who have an abnormal cervical appearance, and those withhigh parity who were lacking cervical screening program.}, keywords = {Cervical cancer,Pap smear,Madinah,Saudi Arabia}, url = {https://journal.waocp.org/article_87406.html}, eprint = {https://journal.waocp.org/article_87406_95c7458c8afe422a5c056c44a3f5372e.pdf} }