@article { author = {Azamjah, Nasrindokht and Soltan-Zadeh, Yasaman and Zayeri, Farid}, title = {Global Trend of Breast Cancer Mortality Rate: A 25-Year Study}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {20}, number = {7}, pages = {2015-2020}, year = {2019}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.31557/APJCP.2019.20.7.2015}, abstract = {Background: breast cancer is the most common cause of cancer death for women worldwide. In the past twodecades, published epidemiological reports in different parts of the world show significant increase in breast cancermortality rate. The aim of this study was to determine the 25-year trend of breast cancer mortality rate in 7 super regionsdefined by the Health Metrics and Evaluation (IHME), i.e. Sub-Saharan Africa, North Africa and Middle East, SouthAsia, Southeast Asia and East Asia and Oceania, Latin America and Caribbean, Central Europe and Eastern Europe andCentral Asia, High-income. Methods: Our study population consisted of 195 world countries in the IHME pre-definedseven super regions. The age-standardized mortality rates from 1990 to 2015 were extracted from the IHME site. Thereference life table for calculating mortality rates was constructed based on the lowest estimated age-specific mortalityrates from all locations with populations over 5 million in the 2015 iteration of GBD. To determine the trend of breastcancer mortality rate, a generalized linear mixed model was fitted separately for each IHME region and super region.Results: Statistical analysis showed a significant increase for breast cancer mortality rate in all super regions, exceptfor High-income super region. For total world countries, the mean breast cancer mortality rate was 13.77 per 100,000in 1990 and the overall slope of mortality rate was 0.7 per 100,000 from 1990 to 2015. The results showed that LatinAmerica and Caribbean the highest increasing trend of breast cancer mortality rate during the years 1990 to 2015 (1.48per 100,000). Conclusion: In general, our finding showed a significant increase in breast cancer mortality rate in theworld during the past 25 years, which could be due to increase in incidence and prevalence of this cancer. Low thisincreasing trend is an alarm for health policy makers in all countries, especially in developing countries and low-incomeregions which experienced sharp slopes of breast cancer mortality rate.}, keywords = {breast cancer,Mortality rate,Trend Analysis}, url = {https://journal.waocp.org/article_88661.html}, eprint = {https://journal.waocp.org/article_88661_5d5b0cd7e925afebbe469524afd9f19b.pdf} }