@article { author = {Abdollahi, Mahbobe and Kasiri, Nayereh and Pourhoseingholi, Mohamad Amin and Baghestani, Ahmad Reza and Esmaily, Habibollah}, title = {Determination of Cut Point in the Age of Colorectal Cancer Diagnosis Using a Survival Cure Model}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {20}, number = {9}, pages = {2819-2823}, year = {2019}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.31557/APJCP.2019.20.9.2819}, abstract = {Background and Objectives: Colorectal Cancer (CRC) is the fourth cancer-related cause of death worldwide.CRC is a multi-stage cancer, which is curable during the early stages of the disease. Therefore, determining the time ofcut-point existence could improve treatment planning and help directly allocate resources. This study aims to determinethe cut point in the age of CRC diagnosis. Methods: This study, covering the course 1985 to 2012, consisted of 345colorectal cancer patients registered in Taleghani Hospital, Tehran, Iran and followed up to 2013. The cut-point in theage of CRC diagnosis was obtained using a mixture cure model. The data were analyzed using SPSS and R, V. 20 and2.15.0, respectively. Results: The results showed that the cut point in the age of CRC diagnosis was 50 years. Basedon our estimation, 65% of the patients diagnosed with CRC at or younger than 50 were cured, while 31% of themdiagnosed older than 50 were cured, and the younger group had a better survival over the older group. Conclusion:Since access to a cut-point and analysis of created prognostic groups are important in screening and treatment planning,our results suggested that it is better to estimate the cut-point in the age of curable cancers in early stages via survivalcure models, and the cure rate would increase by CRC timely screening.}, keywords = {colorectal cancer,Survival Analysis,survival cure model,change point,cut point}, url = {https://journal.waocp.org/article_88715.html}, eprint = {https://journal.waocp.org/article_88715_f451e30f9eda53356c2300df9e0371cc.pdf} }